Association of polymorphisms in the endocannabinoid system
genes with myocardial infarction and plasma cholesterol levels

J 2015

Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels

CHMELÍKOVÁ, Monika; Lukáš PÁCAL; Lenka ŠPINAROVÁ and Anna VAŠKŮ

Basic information

Original name

Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels

Name in Czech

Asociace polymorfizmů v genech endokanabinoidního systému s infarktem myokardu a plazmatickou hladinou cholesterolu

Authors

CHMELÍKOVÁ, Monika (203 Czech Republic, guarantor, belonging to the institution); Lukáš PÁCAL (203 Czech Republic, belonging to the institution); Lenka ŠPINAROVÁ (203 Czech Republic) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution)

Edition

Biomedical Papers, Olomouc, Palacky University, 2015, 1213-8118

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Czech Republic

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 0.924

RIV identification code

RIV/00216224:14110/15:00082099

Organization unit

Faculty of Medicine

DOI

https://doi.org/10.5507/bp.2014.043

UT WoS

000366566700004

EID Scopus

2-s2.0-84949642993

Keywords (in Czech)

chronické srdeční selhání; endokanabinoidní systém; hydroláza amidů mastných kyselin

Keywords in English

chronic heart failure; endocannabinoid system; fatty acid amide hydrolase; cannabinoid receptor; myocardial infarction cholesterol

Abstract

In the original language

Aims. The aim of this study was to investigate the relationship between selected symptoms of chronic heart failure (myocardial infarction, plasma cholesterol level) and single nucleotide polymorphisms (SNPs) in the FAAH and CNR1 genes. Methods. A case – control study involving 155 patients with chronic heart failure and 169 age- and sex-matched healthy subjects. We detected SNPs 385 C/A (rs324420) in the FAAH and 1359 G/A (rs1049353) in the CNR1 genes using the polymerase chain reaction and restriction analysis. Genotype and allele frequencies were compared between patients and controls as well as between patients with and without myocardial infarction. Results. No significant differences in genotype or allelic frequencies between patients and controls were found (P > 0.05). Carriers of the FAAH A allele had a 2.37-fold increase in the risk of myocardial infarction (odds ratio 2.37, 95% confidence interval 1.36-6.93, P = 0.01). Homozygous carriers of genotype AA of CNR1 SNP 1359 had significantly higher plasma cholesterol levels than carriers of GG and GA genotypes in patients (P = 0.04). Conclusions. The study results suggest a role for allele A of the FAAH 385 variant as a risk factor for myocardial infarction. Genotype AA of CNR1 1359 variant probably affects plasma cholesterol levels. Pharmacological intervention in this system could modify the therapeutic approach to certain cardiovascular disorders.

Cite

CHMELÍKOVÁ, Monika; Lukáš PÁCAL; Lenka ŠPINAROVÁ and Anna VAŠKŮ. Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels. Biomedical Papers. Olomouc: Palacky University, 2015, vol. 159, No 4, p. 535-539. ISSN 1213-8118. Available from: https://doi.org/10.5507/bp.2014.043.

@article{1197074,
   author = {Chmelíková, Monika and Pácal, Lukáš and Špinarová, Lenka and Vašků, Anna},
   article_location = {Olomouc},
   article_number = {4},
   doi = {https://doi.org/10.5507/bp.2014.043},
   keywords = {chronic heart failure; endocannabinoid system; fatty acid amide hydrolase; cannabinoid receptor; myocardial infarction cholesterol},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers},
   title = {Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels},
   volume = {159},
   year = {2015}
}

TY  - JOUR
ID  - 1197074
AU  - Chmelíková, Monika - Pácal, Lukáš - Špinarová, Lenka - Vašků, Anna
PY  - 2015
TI  - Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels
JF  - Biomedical Papers
VL  - 159
IS  - 4
SP  - 535-539
EP  - 535-539
PB  - Palacky University
SN  - 12138118
KW  - chronic heart failure
KW  - endocannabinoid system
KW  - fatty acid amide hydrolase
KW  - cannabinoid receptor
KW  - myocardial infarction cholesterol
N2  - Aims. The aim of this study was to investigate the relationship between selected symptoms of chronic heart failure (myocardial infarction, plasma cholesterol level) and single nucleotide polymorphisms (SNPs) in the FAAH and CNR1 genes. Methods. A case – control study involving 155 patients with chronic heart failure and 169 age- and sex-matched healthy subjects. We detected SNPs 385 C/A (rs324420) in the FAAH and 1359 G/A (rs1049353) in the CNR1 genes using the polymerase chain reaction and restriction analysis. Genotype and allele frequencies were compared between patients and controls as well as between patients with and without myocardial infarction. Results. No significant differences in genotype or allelic frequencies between patients and controls were found (P > 0.05). Carriers of the FAAH A allele had a 2.37-fold increase in the risk of myocardial infarction (odds ratio 2.37, 95% confidence interval 1.36-6.93, P = 0.01). Homozygous carriers of genotype AA of CNR1 SNP 1359 had significantly higher plasma cholesterol levels than carriers of GG and GA genotypes in patients (P = 0.04). Conclusions. The study results suggest a role for allele A of the FAAH 385 variant as a risk factor for myocardial infarction. Genotype AA of CNR1 1359 variant probably affects plasma cholesterol levels. Pharmacological intervention in this system could modify the therapeutic approach to certain cardiovascular disorders.
ER  -

CHMELÍKOVÁ, Monika; Lukáš PÁCAL; Lenka ŠPINAROVÁ and Anna VAŠKŮ. Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels. \textit{Biomedical Papers}. Olomouc: Palacky University, 2015, vol.~159, No~4, p.~535-539. ISSN~1213-8118. Available from: https://doi.org/10.5507/bp.2014.043.

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