2014
Functional Imaging of the Cerebellum and Basal Ganglia During Predictive Motor Timing in Early Parkinson's Disease
ČECHOVÁ, Ivica, Ovidiu V LUNGU, Radek MAREČEK, Michal MIKL, Tomáš GESCHEIDT et. al.Základní údaje
Originální název
Functional Imaging of the Cerebellum and Basal Ganglia During Predictive Motor Timing in Early Parkinson's Disease
Autoři
ČECHOVÁ, Ivica (703 Slovensko, domácí), Ovidiu V LUNGU (124 Kanada), Radek MAREČEK (203 Česká republika, domácí), Michal MIKL (203 Česká republika, domácí), Tomáš GESCHEIDT (203 Česká republika), Petr KRUPA (203 Česká republika) a Martin BAREŠ (203 Česká republika, garant, domácí)
Vydání
Journal of Neuroimaging, Hoboken, USA, WILEY-BLACKWELL, 2014, 1051-2284
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30000 3. Medical and Health Sciences
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 1.734
Kód RIV
RIV/00216224:14110/14:00076462
Organizační jednotka
Lékařská fakulta
UT WoS
000329509100008
Klíčová slova anglicky
Basal ganglia; cerebellum; fMRI; Parkinson's disease; prediction; timing
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 16. 9. 2014 12:54, Ing. Mgr. Věra Pospíšilíková
Anotace
V originále
BACKGROUND AND PURPOSEThe basal ganglia and the cerebellum have both emerged as important structures involved in the processing of temporal information. METHODSWe examined the roles of the cerebellum and striatum in predictive motor timing during a target interception task in healthy individuals (HC group; n = 21) and in patients with early Parkinson's disease (early stage PD group; n = 20) using functional magnetic resonance imaging. RESULTSDespite having similar hit ratios, the PD failed more often than the HC to postpone their actions until the right moment and to adapt their behavior from one trial to the next. We found more activation in the right cerebellar lobule VI in HC than in early stage PD during successful trials. Successful trial-by-trial adjustments were associated with higher activity in the right putamen and lobule VI of the cerebellum in HC. CONCLUSIONSWe conclude that both the cerebellum and striatum are involved in predictive motor timing tasks. The cerebellar activity is associated exclusively with the postponement of action until the right moment, whereas both the cerebellum and striatum are needed for successful adaptation of motor actions from one trial to the next. We found a general hypoactivation'' of basal ganglia and cerebellum in early stage PD relative to HC, indicating that even in early stages of the PD there could be functional perturbations in the motor system beyond striatum.
Návaznosti
ED1.1.00/02.0068, projekt VaV |
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MSM0021622404, záměr |
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