'Exploring synthetic lethal interaction between Checkpoint Kinase 1(CHK1) and DNA replication stress

SAMADDER, Pounami. 'Exploring synthetic lethal interaction between Checkpoint Kinase 1(CHK1) and DNA replication stress. In EMBO YIP Sectoral meeting - Genome Integrity Forum. 2014.

Základní údaje

Originální název

'Exploring synthetic lethal interaction between Checkpoint Kinase 1(CHK1) and DNA replication stress

Autoři

SAMADDER, Pounami

Vydání

EMBO YIP Sectoral meeting - Genome Integrity Forum, 2014

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Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

10600 1.6 Biological sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ne

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

CHK1 DNA repair cancer

Klíčová slova anglicky

CHK1 DNA repair cancer

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Anotace

V originále

Complex networks of redundant surveillance mechanisms, namely evolutionarily conserved DNA damage response (DDR) and checkpoints, maintain genomic integrity following various genomic insults. Exploring synthetic lethal interactions between DNA repair pathways have wide appliance to the treatment of many types of malignancies. One of the key players in genome surveillance pathways is a protein kinase, CHK1. DNA damage and replication stress supposedly induces activation of CHK1, which then transduces the checkpoint signal and aids cell cycle arrest allowing time for DNA repair. Hence, CHK1 represents druggable molecular target for inhibition following replication stress induced by chemotherapeutic agents.