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@proceedings{1198373,
author = {Samadder, Pounami},
booktitle = {EMBO YIP Sectoral meeting - Genome Integrity Forum},
keywords = {CHK1 DNA repair cancer},
language = {eng},
title = {'Exploring synthetic lethal interaction between Checkpoint Kinase 1(CHK1) and DNA replication stress},
url = {http://www.med.muni.cz/index.php?id=1210&akce=46074757},
year = {2014}
}
TY - CONF
ID - 1198373
AU - Samadder, Pounami
PY - 2014
TI - 'Exploring synthetic lethal interaction between Checkpoint Kinase 1(CHK1) and DNA replication stress
KW - CHK1 DNA repair cancer
UR - http://www.med.muni.cz/index.php?id=1210&akce=46074757
L2 - http://www.med.muni.cz/index.php?id=1210&akce=46074757
N2 - Complex networks of redundant surveillance mechanisms, namely evolutionarily conserved DNA damage response (DDR) and checkpoints, maintain genomic integrity following various genomic insults. Exploring synthetic lethal interactions between DNA repair pathways have wide appliance to the treatment of many types of malignancies. One of the key players in genome surveillance pathways is a protein kinase, CHK1. DNA damage and replication stress supposedly induces activation of CHK1, which then transduces the checkpoint signal and aids cell cycle arrest allowing time for DNA repair. Hence, CHK1 represents druggable molecular target for inhibition following replication stress induced by chemotherapeutic agents.
ER -
SAMADDER, Pounami. 'Exploring synthetic lethal interaction between Checkpoint Kinase 1(CHK1) and DNA replication stress. In \textit{EMBO YIP Sectoral meeting - Genome Integrity Forum}. 2014.
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