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@article{1199011,
author = {Horská, Kateřina and Kučerová, Jana and Suchý, Pavel and Kotolová, Hana},
article_location = {Praha},
article_number = {4},
keywords = {metabolic syndrome; insulin resistance; adipose tissue; adipokines},
language = {eng},
issn = {1210-7816},
journal = {Česká a slovenská farmacie},
title = {Metabolic syndrome – dysregulation of adipose tissue endocrine function},
url = {https://www.prolekare.cz/en/journals/czech-and-slovak-pharmacy/2014-4-3/metabolic-syndrome-dysregulation-of-adipose-tissue-endocrine-function-49586},
volume = {63},
year = {2014}
}
TY - JOUR
ID - 1199011
AU - Horská, Kateřina - Kučerová, Jana - Suchý, Pavel - Kotolová, Hana
PY - 2014
TI - Metabolic syndrome – dysregulation of adipose tissue endocrine function
JF - Česká a slovenská farmacie
VL - 63
IS - 4
SP - 152-159
EP - 152-159
PB - Česká lékařská společnost J.E. Purkyně
SN - 12107816
KW - metabolic syndrome
KW - insulin resistance
KW - adipose tissue
KW - adipokines
UR - https://www.prolekare.cz/en/journals/czech-and-slovak-pharmacy/2014-4-3/metabolic-syndrome-dysregulation-of-adipose-tissue-endocrine-function-49586
L2 - https://www.prolekare.cz/en/journals/czech-and-slovak-pharmacy/2014-4-3/metabolic-syndrome-dysregulation-of-adipose-tissue-endocrine-function-49586
N2 - Metabolic syndrome, a condition increasing cardiovascular morbidity, mortality and risk for diabetes mellitus type 2, is currently worldwide reaching epidemic proportions. This complex disorder represents an urgent challenge for new pharmacotherapeutic strategies formulation. Pathophysiological mechanisms underlying metabolic syndrome are not completely understood, nevertheless growing evidence is supporting the hypothesis that multiple metabolic dysregulations do contribute to its development. A potential target for pharmacological intervention is considered to be dysregulation of adipose tissue endocrine/paracrine function. Specific adipokines, proteins secreted by the adipose tissue, with some pleiotropic effects, have been identified with strong association to regulation of energy metabolism, appetite, insulin signaling, tissue insulin sensitivity and the proinflammatory state related to metabolic syndrome. The aim of this paper is to provide a brief overview of endocrine/paracrine functions of the adipose tissue with regard to metabolic syndrome development and pathophysiology and particular adipokines as potential targets for innovative pharmacotherapeutic approaches.
ER -
HORSKÁ, Kateřina, Jana KUČEROVÁ, Pavel SUCHÝ a Hana KOTOLOVÁ. Metabolic syndrome – dysregulation of adipose tissue endocrine function. \textit{Česká a slovenská farmacie}. Praha: Česká lékařská společnost J.E. Purkyně, 2014, roč.~63, č.~4, s.~152-159. ISSN~1210-7816.
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