Serum and Tissue Zinc in Epithelial Malignancies: A
Meta-Analysis

J 2014

Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis

GUMULEC, Jaromír, Michal MASAŘÍK, Vojtěch ADAM, Tomas ECKSCHLAGER, Ivo PROVAZNIK et. al.

Basic information

Original name

Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis

Authors

GUMULEC, Jaromír (203 Czech Republic, belonging to the institution), Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution), Vojtěch ADAM (203 Czech Republic), Tomas ECKSCHLAGER (203 Czech Republic), Ivo PROVAZNIK (203 Czech Republic) and René KIZEK (203 Czech Republic)

Edition

Plos One, San Francisco, Public library science, 2014, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.234

RIV identification code

RIV/00216224:14110/14:00080143

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1371/journal.pone.0099790

UT WoS

000338508200042

Keywords in English

TRACE-ELEMENT CONCENTRATIONS; NEUTRON-ACTIVATION ANALYSIS; LUNG-CANCER PATIENTS; X-RAY-FLUORESCENCE; CU-ZN RATIO; BREAST-CANCER; HUMAN PROSTATE; COPPER/ZINC RATIO; VITAMIN-A; HEPATOCELLULAR-CARCINOMA

Abstract

V originále

Background and Objectives: Current studies give us inconsistent results regarding the association of neoplasms and zinc(II) serum and tissues concentrations. The results of to-date studies using meta-analysis are summarized in this paper. Methods: Web of Science (Science citation index expanded), PubMed (Medline), Embase and CENTRAL were searched. Articles were reviewed by two evaluators; quality was assessed by Newcastle-Ottawa scale; meta-analysis was performed including meta-regression and publication bias analysis. Results: Analysis was performed on 114 case control, cohort and cross-sectional studies of 22737 participants. Decreased serum zinc level was found in patients with lung (effect size = -1.04), head and neck (effect size = -1.43), breast (effect size = -0.93), liver (effect size = -2.29), stomach (effect size = -1.59), and prostate (effect size = -1.36) cancers; elevation was not proven in any tumor. More specific zinc patterns are evident at tissue level, showing increase in breast cancer tissue (effect size = 1.80) and decrease in prostatic (effect size = -3.90), liver (effect size = -8.26), lung (effect size = -3.12), and thyroid cancer (effect size = -2.84). The rest of the included tumors brought ambiguous results, both in serum and tissue zinc levels across the studies. The association between zinc level and stage or grade of tumor has not been revealed by meta-regression. Conclusion: This study provides evidence on cancer-specific tissue zinc level alteration. Although serum zinc decrease was associated with most tumors mentioned herein, further - prospective - studies are needed.

Links

NT14337, research and development project

Name: Studium a charakterizace primárních nádorových buněčných linií spinocelulárních karcinomů v oblasti hlavy a krku a jejich maligní potenciál.

Investor: Ministry of Health of the CR

Citovat

GUMULEC, Jaromír, Michal MASAŘÍK, Vojtěch ADAM, Tomas ECKSCHLAGER, Ivo PROVAZNIK and René KIZEK. Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis. Plos One. San Francisco: Public library science, 2014, vol. 9, No 6, p. "e99790", 11 pp. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0099790.

@article{1199012,
   author = {Gumulec, Jaromír and Masařík, Michal and Adam, Vojtěch and Eckschlager, Tomas and Provaznik, Ivo and Kizek, René},
   article_location = {San Francisco},
   article_number = {6},
   doi = {http://dx.doi.org/10.1371/journal.pone.0099790},
   keywords = {TRACE-ELEMENT CONCENTRATIONS; NEUTRON-ACTIVATION ANALYSIS; LUNG-CANCER PATIENTS; X-RAY-FLUORESCENCE; CU-ZN RATIO; BREAST-CANCER; HUMAN PROSTATE; COPPER/ZINC RATIO; VITAMIN-A; HEPATOCELLULAR-CARCINOMA},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos One},
   title = {Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis},
   volume = {9},
   year = {2014}
}

TY  - JOUR
ID  - 1199012
AU  - Gumulec, Jaromír - Masařík, Michal - Adam, Vojtěch - Eckschlager, Tomas - Provaznik, Ivo - Kizek, René
PY  - 2014
TI  - Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis
JF  - Plos One
VL  - 9
IS  - 6
SP  - "e99790"
EP  - "e99790"
PB  - Public library science
SN  - 19326203
KW  - TRACE-ELEMENT CONCENTRATIONS
KW  - NEUTRON-ACTIVATION ANALYSIS
KW  - LUNG-CANCER PATIENTS
KW  - X-RAY-FLUORESCENCE
KW  - CU-ZN RATIO
KW  - BREAST-CANCER
KW  - HUMAN PROSTATE
KW  - COPPER/ZINC RATIO
KW  - VITAMIN-A
KW  - HEPATOCELLULAR-CARCINOMA
N2  - Background and Objectives: Current studies give us inconsistent results regarding the association of neoplasms and zinc(II) serum and tissues concentrations. The results of to-date studies using meta-analysis are summarized in this paper. Methods: Web of Science (Science citation index expanded), PubMed (Medline), Embase and CENTRAL were searched. Articles were reviewed by two evaluators; quality was assessed by Newcastle-Ottawa scale; meta-analysis was performed including meta-regression and publication bias analysis. Results: Analysis was performed on 114 case control, cohort and cross-sectional studies of 22737 participants. Decreased serum zinc level was found in patients with lung (effect size = -1.04), head and neck (effect size = -1.43), breast (effect size = -0.93), liver (effect size = -2.29), stomach (effect size = -1.59), and prostate (effect size = -1.36) cancers; elevation was not proven in any tumor. More specific zinc patterns are evident at tissue level, showing increase in breast cancer tissue (effect size = 1.80) and decrease in prostatic (effect size = -3.90), liver (effect size = -8.26), lung (effect size = -3.12), and thyroid cancer (effect size = -2.84). The rest of the included tumors brought ambiguous results, both in serum and tissue zinc levels across the studies. The association between zinc level and stage or grade of tumor has not been revealed by meta-regression. Conclusion: This study provides evidence on cancer-specific tissue zinc level alteration. Although serum zinc decrease was associated with most tumors mentioned herein, further - prospective - studies are needed.
ER  -

GUMULEC, Jaromír, Michal MASAŘÍK, Vojtěch ADAM, Tomas ECKSCHLAGER, Ivo PROVAZNIK and René KIZEK. Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis. \textit{Plos One}. San Francisco: Public library science, 2014, vol.~9, No~6, p.~''e99790'', 11 pp. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0099790.

Detailed Information on Publication Record