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@article{1202606, author = {Pásek, Michal and Šimurda, Jiří}, article_location = {Praha}, article_number = {6}, keywords = {cardiac cell; intracellular Ca2+ dynamics; t-tubule; quantitative modelling}, language = {cze}, issn = {1802-1484}, journal = {Engineering mechanics}, title = {A MATHEMATICAL MODEL OF RAT VENTRICULAR CARDIOMYOCYTE WITH A NOVEL DESCRIPTION OF INTRACELLULAR AND T-TUBULAR Ca2+ DYNAMICS}, volume = {20}, year = {2013} }
TY - JOUR ID - 1202606 AU - Pásek, Michal - Šimurda, Jiří PY - 2013 TI - A MATHEMATICAL MODEL OF RAT VENTRICULAR CARDIOMYOCYTE WITH A NOVEL DESCRIPTION OF INTRACELLULAR AND T-TUBULAR Ca2+ DYNAMICS JF - Engineering mechanics VL - 20 IS - 6 SP - 471-480 EP - 471-480 PB - Association for Engineering Mechanics SN - 18021484 KW - cardiac cell KW - intracellular Ca2+ dynamics KW - t-tubule KW - quantitative modelling N2 - In this paper, we present a novel quantitative description of intracellular and t-tubular Ca2+ dynamics in a model of rat cardiac ventricular myocyte. In order to simulate recently published data, the model incorporates t-tubular and peripheral dyads and intracellular subspaces, segmentation of the t-tubular luminal volume, reformulation of the inactivation properties of t-tubular and peripheral L-type calcium current (ICa) and a description of exogenous Ca2+ buffer function in the intracellular space. The model is used to explore activity-induced changes of ion concentrations in the intracellular and t-tubular spaces and their role in excitation – contraction coupling in ventricular myocytes. ER -
PÁSEK, Michal a Jiří ŠIMURDA. A MATHEMATICAL MODEL OF RAT VENTRICULAR CARDIOMYOCYTE WITH A NOVEL DESCRIPTION OF INTRACELLULAR AND T-TUBULAR Ca2+ DYNAMICS. \textit{Engineering mechanics}. Praha: Association for Engineering Mechanics, 2013, roč.~20, č.~6, s.~471-480. ISSN~1802-1484.
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