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@article{1202606,
author = {Pásek, Michal and Šimurda, Jiří},
article_location = {Praha},
article_number = {6},
keywords = {cardiac cell; intracellular Ca2+ dynamics; t-tubule; quantitative modelling},
language = {cze},
issn = {1802-1484},
journal = {Engineering mechanics},
title = {A MATHEMATICAL MODEL OF RAT VENTRICULAR CARDIOMYOCYTE WITH A NOVEL DESCRIPTION OF INTRACELLULAR AND T-TUBULAR Ca2+ DYNAMICS},
volume = {20},
year = {2013}
}
TY - JOUR
ID - 1202606
AU - Pásek, Michal - Šimurda, Jiří
PY - 2013
TI - A MATHEMATICAL MODEL OF RAT VENTRICULAR CARDIOMYOCYTE WITH A NOVEL DESCRIPTION OF INTRACELLULAR AND T-TUBULAR Ca2+ DYNAMICS
JF - Engineering mechanics
VL - 20
IS - 6
SP - 471-480
EP - 471-480
PB - Association for Engineering Mechanics
SN - 18021484
KW - cardiac cell
KW - intracellular Ca2+ dynamics
KW - t-tubule
KW - quantitative modelling
N2 - In this paper, we present a novel quantitative description of intracellular and t-tubular Ca2+ dynamics in a model of rat cardiac ventricular myocyte. In order to simulate recently published data, the model incorporates t-tubular and peripheral dyads and intracellular subspaces, segmentation of the t-tubular luminal volume, reformulation of the inactivation properties of t-tubular and peripheral L-type calcium current (ICa) and a description of exogenous Ca2+ buffer function in the intracellular space. The model is used to explore activity-induced changes of ion concentrations in the intracellular and t-tubular spaces and their role in excitation – contraction coupling in ventricular myocytes.
ER -
PÁSEK, Michal a Jiří ŠIMURDA. A MATHEMATICAL MODEL OF RAT VENTRICULAR CARDIOMYOCYTE WITH A NOVEL DESCRIPTION OF INTRACELLULAR AND T-TUBULAR Ca2+ DYNAMICS. \textit{Engineering mechanics}. Praha: Association for Engineering Mechanics, 2013, roč.~20, č.~6, s.~471-480. ISSN~1802-1484.
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