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@article{1202680,
author = {Pásek, Michal and Šimurda, Jiří and Orchard, Clive H.},
article_location = {New York},
article_number = {920208},
doi = {http://dx.doi.org/10.1155/2014/920208},
keywords = {SARCOPLASMIC-RETICULUM; T-TUBULES; CARDIAC MYOCYTES; SURFACE-MEMBRANE; CALCIUM-RELEASE; INACTIVATION; EXCHANGE; CHANNELS; MUSCLE},
language = {eng},
issn = {2314-6133},
journal = {BioMed Research International},
title = {Effect of Ca2+ Efflux Pathway Distribution and Exogenous Ca2+ Buffers on Intracellular Ca2+ Dynamics in the Rat Ventricular Myocyte: A Simulation Study},
volume = {2014},
year = {2014}
}
TY - JOUR
ID - 1202680
AU - Pásek, Michal - Šimurda, Jiří - Orchard, Clive H.
PY - 2014
TI - Effect of Ca2+ Efflux Pathway Distribution and Exogenous Ca2+ Buffers on Intracellular Ca2+ Dynamics in the Rat Ventricular Myocyte: A Simulation Study
JF - BioMed Research International
VL - 2014
IS - 920208
SP - 1-12
EP - 1-12
PB - Hindawi Publishing Corporation
SN - 23146133
KW - SARCOPLASMIC-RETICULUM
KW - T-TUBULES
KW - CARDIAC MYOCYTES
KW - SURFACE-MEMBRANE
KW - CALCIUM-RELEASE
KW - INACTIVATION
KW - EXCHANGE
KW - CHANNELS
KW - MUSCLE
N2 - We have used a previously published computer model of the rat cardiac ventricular myocyte to investigate the effect of changing the distribution of Ca2+ efflux pathways (SERCA, Na+/Ca2+ exchange, and sarcolemmal Ca2+ ATPase) between the dyad and bulk cytoplasm and the effect of adding exogenous Ca2+ buffers (BAPTA or EGTA), which are used experimentally to differentially buffer Ca2+ in the dyad and bulk cytoplasm, on cellular Ca2+ cycling. Increasing the dyadic fraction of a particular Ca2+ efflux pathway increases the amount of Ca2+ removed by that pathway, with corresponding changes in Ca2+ efflux from the bulk cytoplasm. The magnitude of these effects varies with the proportion of the total Ca2+ removed from the cytoplasm by that pathway. Differences in the response to EGTA and BAPTA, including changes in Ca2+-dependent inactivation of the L-type Ca2+ current, resulted from the buffers acting as slow and fast "shuttles," respectively, removing Ca2+ from the dyadic space. The data suggest that complex changes in dyadic Ca2+ and cellular Ca2+ cycling occur as a result of changes in the location of Ca2+ removal pathways or the presence of exogenous Ca2+ buffers, although changing the distribution of Ca2+ efflux pathways has relatively small effects on the systolic Ca2+ transient.
ER -
PÁSEK, Michal, Jiří ŠIMURDA a Clive H. ORCHARD. Effect of Ca2+ Efflux Pathway Distribution and Exogenous Ca2+ Buffers on Intracellular Ca2+ Dynamics in the Rat Ventricular Myocyte: A Simulation Study. \textit{BioMed Research International}. New York: Hindawi Publishing Corporation, 2014, roč.~2014, č.~920208, s.~1-12. ISSN~2314-6133. Dostupné z: https://dx.doi.org/10.1155/2014/920208.
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