MiR-205 as a tumor suppressor in adenocarcinoma and oncogene in
spinocellular carcinoma of esophageal cancer.

a 2014

MiR-205 as a tumor suppressor in adenocarcinoma and oncogene in spinocellular carcinoma of esophageal cancer.

HÉŽOVÁ, Renata; Alena KOVAŘÍKOVÁ; Josef SROVNAL; Milada ZEMANOVÁ; Tomáš HARUŠTIAK et. al.

Základní údaje

Originální název

MiR-205 as a tumor suppressor in adenocarcinoma and oncogene in spinocellular carcinoma of esophageal cancer.

Autoři

HÉŽOVÁ, Renata; Alena KOVAŘÍKOVÁ; Josef SROVNAL; Milada ZEMANOVÁ; Tomáš HARUŠTIAK; Jiří EHRMANN; Marian HAJDÚCH; Pavel FABIAN; Milana ŠACHLOVÁ a Ondřej SLABÝ

Vydání

Regulatory RNAs, Berkeley, CA, USA, 2014

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

miR-205; esophageal cancer; miRNA; cancer biomarkers

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 10. 2014 16:51, Mgr. Petra Vychytilová, Ph.D.

Anotace

V originále

Esophageal cancer is disease with very poor prognosis. There are two main types of esophageal carcinoma: adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). The aim of this study is to identify potential microRNA (miRNA) as biomarkers of esophageal cancer.Our results indicate a significantly decreased expression of miR-205 in EAC patients (n=22) in comparison with adjacent mucosa and significantly decreased expression of miR-205 in EAC patients in comparison with ESSC (n=22).Increased level of miR-205 is associated with a significantly better overall survival of EAC patients. Experimentally decreased level of anti-miR-205 in ESCC cell line was significantly affecting cell proliferation, migration and anchorage independent growth. Conversely, experimental increase of miR-205 in EAC cell line leads to decrease in cell proliferation and cell migration. This study may suggest the possibility of using miR-205 as biomarker for more reliable diagnosis of esophageal cancer and distinguishing of EAC from ESCC.

Návaznosti

NT13547, projekt VaV

Název: Studium mikroRNA a genů asociovaných s procesem epiteliálně-mezenchymální tranzice jako potenciálních markerů pro predikci rizika a časný záchyt metastazování u pacientů s renálním karcinomem

NT13549, projekt VaV

Název: Vytvoření diagnostické sady cirkulujících mikroRNA pro neinvazivní časnou diagnostiku a sledování pacientů s kolorektálním karcinomem

NT13860, projekt VaV

Název: Studium signální dráhy EGFR a expresních profilů mikroRNA v predikci odpovědi na cílenou anti-EGFR terapii u pacientů s kolorektálním karcinomem s nemutovanou variantou onkogenu KRAS

Citovat

HÉŽOVÁ, Renata; Alena KOVAŘÍKOVÁ; Josef SROVNAL; Milada ZEMANOVÁ; Tomáš HARUŠTIAK; Jiří EHRMANN; Marian HAJDÚCH; Pavel FABIAN; Milana ŠACHLOVÁ a Ondřej SLABÝ. MiR-205 as a tumor suppressor in adenocarcinoma and oncogene in spinocellular carcinoma of esophageal cancer. In Regulatory RNAs, Berkeley, CA, USA. 2014.

@proceedings{1203696,
   author = {Héžová, Renata and Kovaříková, Alena and Srovnal, Josef and Zemanová, Milada and Haruštiak, Tomáš and Ehrmann, Jiří and Hajdúch, Marian and Fabian, Pavel and Šachlová, Milana and Slabý, Ondřej},
   booktitle = {Regulatory RNAs, Berkeley, CA, USA},
   keywords = {miR-205; esophageal cancer; miRNA; cancer biomarkers},
   language = {eng},
   title = {MiR-205 as a tumor suppressor in adenocarcinoma and oncogene in spinocellular carcinoma of esophageal cancer.},
   year = {2014}
}

TY  - CONF
ID  - 1203696
AU  - Héžová, Renata - Kovaříková, Alena - Srovnal, Josef - Zemanová, Milada - Haruštiak, Tomáš - Ehrmann, Jiří - Hajdúch, Marian - Fabian, Pavel - Šachlová, Milana - Slabý, Ondřej
PY  - 2014
TI  - MiR-205 as a tumor suppressor in adenocarcinoma and oncogene in spinocellular carcinoma of esophageal cancer.
KW  - miR-205
KW  - esophageal cancer
KW  - miRNA
KW  - cancer biomarkers
N2  - Esophageal cancer is disease with very poor prognosis. There are two main types of esophageal carcinoma: adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). The aim of this study is to identify potential microRNA (miRNA) as biomarkers of esophageal cancer.Our results indicate a significantly decreased expression of miR-205 in EAC patients (n=22) in comparison with adjacent mucosa and significantly decreased expression of miR-205 in EAC patients in comparison with ESSC (n=22).Increased level of miR-205 is associated with a significantly better overall survival of EAC patients. Experimentally decreased level of anti-miR-205 in ESCC cell line was significantly affecting cell proliferation, migration and anchorage independent growth. Conversely, experimental increase of miR-205 in EAC cell line leads to decrease in cell proliferation and cell migration. This study may suggest the possibility of using miR-205 as biomarker for more reliable diagnosis of esophageal cancer and distinguishing of EAC from ESCC.
ER  -

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