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@proceedings{1204953,
author = {Stejskal, Stanislav and Stejskal, Karel and Štěpka, Karel and Matějková, Martina and Zdráhal, Zbyněk and Krontorád Koutná, Irena},
booktitle = {EMBO Stem Cells in Cancer and Regenerative Medicine},
keywords = {H3K56ac; cancer cells; cell cycle},
language = {eng},
title = {H3K56ac distribution in cancer and embryonic cell lines during cell cycle},
year = {2014}
}
TY - CONF
ID - 1204953
AU - Stejskal, Stanislav - Stejskal, Karel - Štěpka, Karel - Matějková, Martina - Zdráhal, Zbyněk - Krontorád Koutná, Irena
PY - 2014
TI - H3K56ac distribution in cancer and embryonic cell lines during cell cycle
KW - H3K56ac
KW - cancer cells
KW - cell cycle
N2 - Acetylation of lysine 56 on histone H3 (H3K56ac) is very rare posttranslational modification in mammalian cells. This H3 core modification increases nucleosome breathing and promotes recruitment of chromatin remodeling complexes and consequently activates gene expression. Elevated level of H3K56ac was observed in cancer and stem cells especially during S and G2 phase of cell cycle. In this study we evaluated if this H3K56ac enhancement is connected with dysregulation of acetylation pathway or simply with increased level of cells in S and G2 phase within the cell population. To determine the role of H3K56ac level during cell cycle in cancer and stem cells we used different approaches (immunohistochemistry, western blot or mass spectrometry).
ER -
STEJSKAL, Stanislav, Karel STEJSKAL, Karel ŠTĚPKA, Martina MATĚJKOVÁ, Zbyněk ZDRÁHAL a Irena KRONTORÁD KOUTNÁ. H3K56ac distribution in cancer and embryonic cell lines during cell cycle. In \textit{EMBO Stem Cells in Cancer and Regenerative Medicine}. 2014.
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