Small-nerve-fiber pathology in critical illness documented by
serial skin biopsies

J 2015

Small-nerve-fiber pathology in critical illness documented by serial skin biopsies

ŠKORŇA, Miroslav; Roman KOPÁČIK; Eva VLČKOVÁ; Blanka ADAMOVÁ; Milena KOŠŤÁLOVÁ et al.

Základní údaje

Originální název

Small-nerve-fiber pathology in critical illness documented by serial skin biopsies

Autoři

ŠKORŇA, Miroslav; Roman KOPÁČIK; Eva VLČKOVÁ; Blanka ADAMOVÁ; Milena KOŠŤÁLOVÁ a Josef BEDNAŘÍK

Vydání

Muscle & nerve, New York, Wiley-Blackwell, 2015, 0148-639X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.713

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/15:00082172

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

critical illness; small fibers; polyneuropathy; myopathy; skin biopsy

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 7. 2015 10:52, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Introduction: Small fiber pathology can develop in the acute phase of critical illness and may explain chronic sensory impairment and pain in critical care survivors. Methods: Eleven adult ischemic stroke patients in a neurocritical care unit were enrolled in an observational cohort study. Intraepidermal never fiber density (IENFD) in the distal leg was assessed on admission to the intensive care unit and 10-14 days later, together with electrophysiological testing. Results: Of the 11 patients recruited, 9 (82%) had sepsis or multiple organ failure. Median IENFD on admission (5.05 fibers/mm) decreased significantly to 2.18 fibers/mm (P <0.001), and abnormal IENFD was found in 8 patients (72.7%). Electrodiagnostic signs of large fiber neuropathy and/or myopathy were found in 6 patients (54.5%), and autonomic dysfunction was found in 2 patients (18.2%). Discussion: Serial IENFD measurements confirmed the development of small fiber sensory involvement in the acute phase of critical illness.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

MUNI/A/0935/2013, interní kód MU

Název: Diagnostika a patofyziologie neuropatické bolesti

Investor: Masarykova univerzita, Diagnostika a patofyziologie neuropatické bolesti, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Přiložené soubory

EL_1209965.pdf

Požádat o autorskou verzi souboru

Citovat

ŠKORŇA, Miroslav; Roman KOPÁČIK; Eva VLČKOVÁ; Blanka ADAMOVÁ; Milena KOŠŤÁLOVÁ a Josef BEDNAŘÍK. Small-nerve-fiber pathology in critical illness documented by serial skin biopsies. Muscle & nerve. New York: Wiley-Blackwell, 2015, roč. 52, č. 1, s. 28-33. ISSN 0148-639X. Dostupné z: https://doi.org/10.1002/mus.24489.

@article{1209965,
   author = {Škorňa, Miroslav and Kopáčik, Roman and Vlčková, Eva and Adamová, Blanka and Košťálová, Milena and Bednařík, Josef},
   article_location = {New York},
   article_number = {1},
   doi = {https://doi.org/10.1002/mus.24489},
   keywords = {critical illness; small fibers; polyneuropathy; myopathy; skin biopsy},
   language = {eng},
   issn = {0148-639X},
   journal = {Muscle & nerve},
   note = {http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291097-4598/issues},
   title = {Small-nerve-fiber pathology in critical illness documented by serial skin biopsies},
   volume = {52},
   year = {2015}
}

TY  - JOUR
ID  - 1209965
AU  - Škorňa, Miroslav - Kopáčik, Roman - Vlčková, Eva - Adamová, Blanka - Košťálová, Milena - Bednařík, Josef
PY  - 2015
TI  - Small-nerve-fiber pathology in critical illness documented by serial skin biopsies
JF  - Muscle & nerve
VL  - 52
IS  - 1
SP  - 28-33
EP  - 28-33
PB  - Wiley-Blackwell
SN  - 0148639X
N1  - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291097-4598/issues
KW  - critical illness
KW  - small fibers
KW  - polyneuropathy
KW  - myopathy
KW  - skin biopsy
N2  - Introduction: Small fiber pathology can develop in the acute phase of critical illness and may explain chronic sensory impairment and pain in critical care survivors. Methods: Eleven adult ischemic stroke patients in a neurocritical care unit were enrolled in an observational cohort study. Intraepidermal never fiber density (IENFD) in the distal leg was assessed on admission to the intensive care unit and 10-14 days later, together with electrophysiological testing. Results: Of the 11 patients recruited, 9 (82%) had sepsis or multiple organ failure. Median IENFD on admission (5.05 fibers/mm) decreased significantly to 2.18 fibers/mm (P <0.001), and abnormal IENFD was found in 8 patients (72.7%). Electrodiagnostic signs of large fiber neuropathy and/or myopathy were found in 6 patients (54.5%), and autonomic dysfunction was found in 2 patients (18.2%). Discussion: Serial IENFD measurements confirmed the development of small fiber sensory involvement in the acute phase of critical illness.
ER  -

ŠKORŇA, Miroslav; Roman KOPÁČIK; Eva VLČKOVÁ; Blanka ADAMOVÁ; Milena KOŠŤÁLOVÁ a Josef BEDNAŘÍK. Small-nerve-fiber pathology in critical illness documented by serial skin biopsies. \textit{Muscle \&{} nerve}. New York: Wiley-Blackwell, 2015, roč.~52, č.~1, s.~28-33. ISSN~0148-639X. Dostupné z: https://doi.org/10.1002/mus.24489.

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