Altered Serum Cytokine Signature in Common Variable
Immunodeficiency

J 2014

Altered Serum Cytokine Signature in Common Variable Immunodeficiency

HEL, Zdenek, Richard P. H. HUIJBREGTS, Jun XU, Jana NECHVÁTALOVÁ, Marcela VLKOVÁ et. al.

Basic information

Original name

Altered Serum Cytokine Signature in Common Variable Immunodeficiency

Authors

HEL, Zdenek (840 United States of America), Richard P. H. HUIJBREGTS (840 United States of America), Jun XU (840 United States of America), Jana NECHVÁTALOVÁ (203 Czech Republic, belonging to the institution), Marcela VLKOVÁ (203 Czech Republic, belonging to the institution) and Jiří LITZMAN (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Clinical Immunology, New York, Springer, 2014, 0271-9142

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.184

RIV identification code

RIV/00216224:14110/14:00077503

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s10875-014-0099-z

UT WoS

000344780000012

Keywords in English

Common variable immunodeficiency; IgA deficiency; cytokine; lymphocyte activation

Abstract

V originále

Purpose Common variable immunodeficiency (CVID) is the most frequent form of primary symptomatic hypogammaglobulinemia. CVID patients display a number of abnormalities in lymphocyte subpopulations including chronic T-cell activation and decreased numbers of circulating CD4+ T cells and NK cells. We and others have recently shown that CVID is associated with increased concentration of soluble CD14 (sCD14) and other factors indicating limited microbial translocation. Methods To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of cytokine serum levels in 36 patients with CVID, 52 patients with selective IgA deficiency (IgAD), and 56 healthy volunteers. Results We show that CVID is associated with elevated serum levels of CXCL-10/IP-10, IL-1R antagonist, TNF-alpha, IL-10, IL-12 (p40), CCL-2/MCP-1, G-CSF, and CCL-11/eotaxin. The detected cytokine signature is consistent with an ongoing activation of cells of myeloid lineage. In contrast, the levels of cytokines typically produced by CD4+ T helper cells of Th1 (IFN-y, IL-2), Th2 (IL-9, IL-13), and Th17 (IL-17) subtypes were suppressed in CVID patients compared to healthy donors. Conclusions Presented data suggest that the altered cytokine profile observed in patients with CVID may be attributed to the activation of monocyte-macrophage and granulocyte lineages, possibly driven by the translocation of bacterial components across the gastrointestinal or respiratory tracts mucosal barrier.

Citovat

HEL, Zdenek, Richard P. H. HUIJBREGTS, Jun XU, Jana NECHVÁTALOVÁ, Marcela VLKOVÁ and Jiří LITZMAN. Altered Serum Cytokine Signature in Common Variable Immunodeficiency. Journal of Clinical Immunology. New York: Springer, 2014, vol. 34, No 8, p. 971-978. ISSN 0271-9142. Available from: https://dx.doi.org/10.1007/s10875-014-0099-z.

@article{1210675,
   author = {Hel, Zdenek and Huijbregts, Richard P. H. and Xu, Jun and Nechvátalová, Jana and Vlková, Marcela and Litzman, Jiří},
   article_location = {New York},
   article_number = {8},
   doi = {http://dx.doi.org/10.1007/s10875-014-0099-z},
   keywords = {Common variable immunodeficiency; IgA deficiency; cytokine; lymphocyte activation},
   language = {eng},
   issn = {0271-9142},
   journal = {Journal of Clinical Immunology},
   title = {Altered Serum Cytokine Signature in Common Variable Immunodeficiency},
   volume = {34},
   year = {2014}
}

TY  - JOUR
ID  - 1210675
AU  - Hel, Zdenek - Huijbregts, Richard P. H. - Xu, Jun - Nechvátalová, Jana - Vlková, Marcela - Litzman, Jiří
PY  - 2014
TI  - Altered Serum Cytokine Signature in Common Variable Immunodeficiency
JF  - Journal of Clinical Immunology
VL  - 34
IS  - 8
SP  - 971-978
EP  - 971-978
PB  - Springer
SN  - 02719142
KW  - Common variable immunodeficiency
KW  - IgA deficiency
KW  - cytokine
KW  - lymphocyte activation
N2  - Purpose Common variable immunodeficiency (CVID) is the most frequent form of primary symptomatic hypogammaglobulinemia. CVID patients display a number of abnormalities in lymphocyte subpopulations including chronic T-cell activation and decreased numbers of circulating CD4+ T cells and NK cells. We and others have recently shown that CVID is associated with increased concentration of soluble CD14 (sCD14) and other factors indicating limited microbial translocation. Methods To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of cytokine serum levels in 36 patients with CVID, 52 patients with selective IgA deficiency (IgAD), and 56 healthy volunteers. Results We show that CVID is associated with elevated serum levels of CXCL-10/IP-10, IL-1R antagonist, TNF-alpha, IL-10, IL-12 (p40), CCL-2/MCP-1, G-CSF, and CCL-11/eotaxin. The detected cytokine signature is consistent with an ongoing activation of cells of myeloid lineage. In contrast, the levels of cytokines typically produced by CD4+ T helper cells of Th1 (IFN-y, IL-2), Th2 (IL-9, IL-13), and Th17 (IL-17) subtypes were suppressed in CVID patients compared to healthy donors. Conclusions Presented data suggest that the altered cytokine profile observed in patients with CVID may be attributed to the activation of monocyte-macrophage and granulocyte lineages, possibly driven by the translocation of bacterial components across the gastrointestinal or respiratory tracts mucosal barrier.
ER  -

HEL, Zdenek, Richard P. H. HUIJBREGTS, Jun XU, Jana NECHVÁTALOVÁ, Marcela VLKOVÁ and Jiří LITZMAN. Altered Serum Cytokine Signature in Common Variable Immunodeficiency. \textit{Journal of Clinical Immunology}. New York: Springer, 2014, vol.~34, No~8, p.~971-978. ISSN~0271-9142. Available from: https://dx.doi.org/10.1007/s10875-014-0099-z.

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