The potential evasion of immune surveillance in mucosa
associated lymphoid tissue lymphoma by DcR2-mediated
up-regulation of nuclear factor-kappa B

J 2015

The potential evasion of immune surveillance in mucosa associated lymphoid tissue lymphoma by DcR2-mediated up-regulation of nuclear factor-kappa B

ANEES, Mariam; Peter HORAK; Ana-Iris SCHIEFER; Petr VAŇHARA; Ahmed EL-GAZZAR et al.

Základní údaje

Originální název

The potential evasion of immune surveillance in mucosa associated lymphoid tissue lymphoma by DcR2-mediated up-regulation of nuclear factor-kappa B

Autoři

ANEES, Mariam; Peter HORAK; Ana-Iris SCHIEFER; Petr VAŇHARA; Ahmed EL-GAZZAR; Paul PERCO; Barbara KIESEWETTER; Leonhard MÜLLAUER; Berthold STREUBEL; Markus RADERER a Krainer MICHAEL

Vydání

Leukemia & Lymphoma, London, Informa Healthcare, 2015, 1042-8194

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.093

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/15:00082176

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

MALT lymphoma; TRAIL; NF-kappa B; DcR2

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 7. 2015 13:18, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

This study investigated expression profiles of tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) pathway components and mechanisms underlying TRAIL-induced apoptosis in mucosa associated lymphoid tissue (MALT) lymphoma. Genetic aberrations including translocations and trisomies were assessed by reverse transcription polymerase chain reaction and fluorescence in situ hybridization. Expression of TRAIL, death receptors 4 and 5, decoy receptors 1 and 2, and FADD-like interleukin-1 b -converting enzyme (FLICE) inhibitory protein was analyzed by immunohistochemistry. All 32 patients under study showed some alterations in TRAIL pathway mainly involving loss of death receptors (37.5%), gain of decoy receptors (3.1%) or both (59.4%). Decoy receptor 2 (DcR2) was highly expressed in patients with normal cytogenetic status as compared to those with cytogenetic aberrations ( p=0.005). Moreover, DcR2 expression correlated signifi cantly with nuclear factor-kappa B (NF- kappa B) expression ( R=0.372, p= 0.047). High expression of DcR2 in patients with normal cytogenetic status and its significant correlation with NF- kappa B expression provides a potential clue to evasion of immune surveillance in cytogenetically normal MALT lymphomas.

Citovat

ANEES, Mariam; Peter HORAK; Ana-Iris SCHIEFER; Petr VAŇHARA; Ahmed EL-GAZZAR; Paul PERCO; Barbara KIESEWETTER; Leonhard MÜLLAUER; Berthold STREUBEL; Markus RADERER a Krainer MICHAEL. The potential evasion of immune surveillance in mucosa associated lymphoid tissue lymphoma by DcR2-mediated up-regulation of nuclear factor-kappa B. Leukemia & Lymphoma. London: Informa Healthcare, 2015, roč. 56, č. 5, s. 1440-1449. ISSN 1042-8194. Dostupné z: https://doi.org/10.3109/10428194.2014.953149.

@article{1210739,
   author = {Anees, Mariam and Horak, Peter and Schiefer, AnaandIris and Vaňhara, Petr and ElandGazzar, Ahmed and Perco, Paul and Kiesewetter, Barbara and Müllauer, Leonhard and Streubel, Berthold and Raderer, Markus and Michael, Krainer},
   article_location = {London},
   article_number = {5},
   doi = {https://doi.org/10.3109/10428194.2014.953149},
   keywords = {MALT lymphoma; TRAIL; NF-kappa B; DcR2},
   language = {eng},
   issn = {1042-8194},
   journal = {Leukemia & Lymphoma},
   note = {http://informahealthcare.com/loi/lal},
   title = {The potential evasion of immune surveillance in mucosa associated lymphoid tissue lymphoma by DcR2-mediated up-regulation of nuclear factor-kappa B},
   volume = {56},
   year = {2015}
}

TY  - JOUR
ID  - 1210739
AU  - Anees, Mariam - Horak, Peter - Schiefer, Ana-Iris - Vaňhara, Petr - El-Gazzar, Ahmed - Perco, Paul - Kiesewetter, Barbara - Müllauer, Leonhard - Streubel, Berthold - Raderer, Markus - Michael, Krainer
PY  - 2015
TI  - The potential evasion of immune surveillance in mucosa associated lymphoid tissue lymphoma by DcR2-mediated up-regulation of nuclear factor-kappa B
JF  - Leukemia & Lymphoma
VL  - 56
IS  - 5
SP  - 1440-1449
EP  - 1440-1449
PB  - Informa Healthcare
SN  - 10428194
N1  - http://informahealthcare.com/loi/lal
KW  - MALT lymphoma
KW  - TRAIL
KW  - NF-kappa B
KW  - DcR2
N2  - This study investigated expression profiles of tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) pathway components and mechanisms underlying TRAIL-induced apoptosis in mucosa associated lymphoid tissue (MALT) lymphoma. Genetic aberrations including translocations and trisomies were assessed by reverse transcription polymerase chain reaction and fluorescence in situ hybridization. Expression of TRAIL, death receptors 4 and 5, decoy receptors 1 and 2, and FADD-like interleukin-1 b -converting enzyme (FLICE) inhibitory protein was analyzed by immunohistochemistry. All 32 patients under study showed some alterations in TRAIL pathway mainly involving loss of death receptors (37.5%), gain of decoy receptors (3.1%) or both (59.4%). Decoy receptor 2 (DcR2) was highly expressed in patients with normal cytogenetic status as compared to those with cytogenetic aberrations ( p=0.005). Moreover, DcR2 expression correlated signifi cantly with nuclear factor-kappa B (NF- kappa B) expression ( R=0.372, p= 0.047). High expression of DcR2 in patients with normal cytogenetic status and its significant correlation with NF- kappa B expression provides a potential clue to evasion of immune surveillance in cytogenetically normal MALT lymphomas.
ER  -

ANEES, Mariam; Peter HORAK; Ana-Iris SCHIEFER; Petr VAŇHARA; Ahmed EL-GAZZAR; Paul PERCO; Barbara KIESEWETTER; Leonhard MÜLLAUER; Berthold STREUBEL; Markus RADERER a Krainer MICHAEL. The potential evasion of immune surveillance in mucosa associated lymphoid tissue lymphoma by DcR2-mediated up-regulation of nuclear factor-kappa B. \textit{Leukemia \&{} Lymphoma}. London: Informa Healthcare, 2015, roč.~56, č.~5, s.~1440-1449. ISSN~1042-8194. Dostupné z: https://doi.org/10.3109/10428194.2014.953149.

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