Long-term survival after alcohol septal ablation for
hypertrophic obstructive cardiomyopathy: a comparison with
general population

J 2014

Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population

VESELKA, Josef; Jan KREJČÍ; Pavol TOMAŠOV a David ZEMÁNEK

Základní údaje

Originální název

Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population

Autoři

VESELKA, Josef; Jan KREJČÍ; Pavol TOMAŠOV a David ZEMÁNEK

Vydání

European heart journal, Oxford, Oxford University Press, 2014, 0195-668X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 15.203

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00077663

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Alcohol septal ablation; Prognosis; Hypertrophic cardiomyopathy

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 4. 2015 14:10, Soňa Böhmová

Anotace

V originále

Methods and results A total of 178 highly symptomatic, consecutive patients (58 +/- 12 years, 53% women) were treated by ASA between April 1998 and April 2013 and followed-up for 4.8 years (IQR 2.1-7.5). At baseline, 155 patients (87%) suffered from dyspnoea >= 3 class of NYHA; at the most recent examination, 87 patients (49%) and 23 patients (13%) reported dyspnoea of NYHA class 1 and >= 3, respectively. The left ventricular outflow gradient was significantly reduced (68 +/- 42 vs. 20 +/- 25 mmHg; P < 0.01). A total of 19 deaths (11%) occurred during 925 patient-years, which means an overall mortality rate of 2.1% per year. Survival free of all-cause mortality at 1, 5, and 10 years was 97% (95% CI, 93-99%), 92% (95% CI, 87-96%), and 82% (95% CI, 70-90%), respectively. This observed mortality was comparable to the expected survival for age- and sex-comparable general population (P = 0.34). According to multivariate analysis, the only independent predictor of all-cause mortality was age at ASA (hazard ratio 1.09, 95% CI 1.04-1.14; P < 0.01). Conclusions This study suggests that in patients with HOCM and important symptoms who underwent ASA, long-term survival after the procedure did not differ significantly from that of the general population.

Citovat

VESELKA, Josef; Jan KREJČÍ; Pavol TOMAŠOV a David ZEMÁNEK. Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population. European heart journal. Oxford: Oxford University Press, 2014, roč. 35, č. 30, s. "2040"-"+", 7 s. ISSN 0195-668X. Dostupné z: https://doi.org/10.1093/eurheartj/eht495.

@article{1211820,
   author = {Veselka, Josef and Krejčí, Jan and Tomašov, Pavol and Zemánek, David},
   article_location = {Oxford},
   article_number = {30},
   doi = {https://doi.org/10.1093/eurheartj/eht495},
   keywords = {Alcohol septal ablation; Prognosis; Hypertrophic cardiomyopathy},
   language = {eng},
   issn = {0195-668X},
   journal = {European heart journal},
   title = {Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population},
   volume = {35},
   year = {2014}
}

TY  - JOUR
ID  - 1211820
AU  - Veselka, Josef - Krejčí, Jan - Tomašov, Pavol - Zemánek, David
PY  - 2014
TI  - Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population
JF  - European heart journal
VL  - 35
IS  - 30
SP  - "2040"-"+"
EP  - "2040"-"+"
PB  - Oxford University Press
SN  - 0195668X
KW  - Alcohol septal ablation
KW  - Prognosis
KW  - Hypertrophic cardiomyopathy
N2  - Methods and results A total of 178 highly symptomatic, consecutive patients (58 +/- 12 years, 53% women) were treated by ASA between April 1998 and April 2013 and followed-up for 4.8 years (IQR 2.1-7.5). At baseline, 155 patients (87%) suffered from dyspnoea >= 3 class of NYHA; at the most recent examination, 87 patients (49%) and 23 patients (13%) reported dyspnoea of NYHA class 1 and >= 3, respectively. The left ventricular outflow gradient was significantly reduced (68 +/- 42 vs. 20 +/- 25 mmHg; P < 0.01). A total of 19 deaths (11%) occurred during 925 patient-years, which means an overall mortality rate of 2.1% per year. Survival free of all-cause mortality at 1, 5, and 10 years was 97% (95% CI, 93-99%), 92% (95% CI, 87-96%), and 82% (95% CI, 70-90%), respectively. This observed mortality was comparable to the expected survival for age- and sex-comparable general population (P = 0.34). According to multivariate analysis, the only independent predictor of all-cause mortality was age at ASA (hazard ratio 1.09, 95% CI 1.04-1.14; P < 0.01). Conclusions This study suggests that in patients with HOCM and important symptoms who underwent ASA, long-term survival after the procedure did not differ significantly from that of the general population.
ER  -

VESELKA, Josef; Jan KREJČÍ; Pavol TOMAŠOV a David ZEMÁNEK. Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population. \textit{European heart journal}. Oxford: Oxford University Press, 2014, roč.~35, č.~30, s.~''2040''-''+'', 7 s. ISSN~0195-668X. Dostupné z: https://doi.org/10.1093/eurheartj/eht495.

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