Quantitative analysis of drug losses administered via
nasogastric tube - In vitro study

J 2015

Quantitative analysis of drug losses administered via nasogastric tube - In vitro study

RUZSÍKOVÁ, Adriána; Lenka SOUČKOVÁ; Pavel SUK; Radka OPATŘILOVÁ; Martina KEJDUŠOVÁ et al.

Základní údaje

Originální název

Quantitative analysis of drug losses administered via nasogastric tube - In vitro study

Název česky

Kvantitativní analýza ztrát léčiv podávaných nasogastrickou sondou - In vitro studie

Autoři

RUZSÍKOVÁ, Adriána; Lenka SOUČKOVÁ; Pavel SUK ; Radka OPATŘILOVÁ; Martina KEJDUŠOVÁ a Vladimír ŠRÁMEK

Vydání

International Journal of Pharmaceutics, Amsterdam, Elsevier Science BV, 2015, 0378-5173

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.994

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/15:00082189

Organizační jednotka

Lékařská fakulta

Klíčová slova česky

nasogastrická sonda; intenzivní péče; lékové formy; enterální výživa; podávání léčiv

Klíčová slova anglicky

Nasogastric tube; Intensive care; Dosage forms; Enteral feeding; Drug administration

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 11. 2015 15:02, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Purpose: Drug administration through nasogastric tube (NGT) is a standard practice but the real amount of the delivered drug is unknown. Therefore, we designed a study to determine the losses of various dosage forms administered by different methods through NGT. Methods: In vitro model was used. Five different administration methods (A–E) and six dosage forms (simple compressed tablets – T/S; film coated tablets – T/FC; enteric coated tablets – T/EC; capsules with powder filling – C/P; capsules containing extended release pellets – C/ER; capsules containing gastro-resistant pellets – C/GR) were investigated. Measurement was repeated six times for each drug-method combination. The overall losses were determined by gravimetry. In method A partial losses associated with each step of drug administration were also determined. Results: Significant drug losses were measured (4–38%). Only methods A (crushing–beaker–syringe–water–NGT) and B (crushing–water–syringe–NGT) were suitable for administration of all tested dosage forms. Method B proved the most effective for all kinds of tablets and C/GR (p < 0.05) and tended to be more effective also for C/ER (p = 0.052) compared to method A. C/P showed minimal losses for both tested methods (B and E). Flushing of the drug through NGT causes major losses during drug administration compared to crushing and transfer (p < 0.05). All methods for intact pellets (C–E) were found inappropriate for clinical practice due to NGT clogging. Conclusions: Choosing a suitable administration method can significantly affect the amount of drugs delivered through NGT.

Citovat

RUZSÍKOVÁ, Adriána; Lenka SOUČKOVÁ; Pavel SUK; Radka OPATŘILOVÁ; Martina KEJDUŠOVÁ a Vladimír ŠRÁMEK. Quantitative analysis of drug losses administered via nasogastric tube - In vitro study. International Journal of Pharmaceutics. Amsterdam: Elsevier Science BV, 2015, roč. 478, č. 1, s. 368-371. ISSN 0378-5173. Dostupné z: https://doi.org/10.1016/j.ijpharm.2014.11.065.

@article{1212460,
   author = {Ruzsíková, Adriána and Součková, Lenka and Suk, Pavel and Opatřilová, Radka and Kejdušová, Martina and Šrámek, Vladimír},
   article_location = {Amsterdam},
   article_number = {1},
   doi = {https://doi.org/10.1016/j.ijpharm.2014.11.065},
   keywords = {Nasogastric tube; Intensive care; Dosage forms; Enteral feeding; Drug administration},
   language = {eng},
   issn = {0378-5173},
   journal = {International Journal of Pharmaceutics},
   title = {Quantitative analysis of drug losses administered via nasogastric tube - In vitro study},
   url = {http://www.sciencedirect.com/science/article/pii/S0378517314008801},
   volume = {478},
   year = {2015}
}

TY  - JOUR
ID  - 1212460
AU  - Ruzsíková, Adriána - Součková, Lenka - Suk, Pavel - Opatřilová, Radka - Kejdušová, Martina - Šrámek, Vladimír
PY  - 2015
TI  - Quantitative analysis of drug losses administered via nasogastric tube - In vitro study
JF  - International Journal of Pharmaceutics
VL  - 478
IS  - 1
SP  - 368-371
EP  - 368-371
PB  - Elsevier Science BV
SN  - 03785173
KW  - Nasogastric tube
KW  - Intensive care
KW  - Dosage forms
KW  - Enteral feeding
KW  - Drug administration
UR  - http://www.sciencedirect.com/science/article/pii/S0378517314008801
N2  - Purpose: Drug administration through nasogastric tube (NGT) is a standard practice but the real amount of the delivered drug is unknown. Therefore, we designed a study to determine the losses of various dosage forms administered by different methods through NGT. Methods: In vitro model was used. Five different administration methods (A–E) and six dosage forms (simple compressed tablets – T/S; film coated tablets – T/FC; enteric coated tablets – T/EC; capsules with powder filling – C/P; capsules containing extended release pellets – C/ER; capsules containing gastro-resistant pellets – C/GR) were investigated. Measurement was repeated six times for each drug-method combination. The overall losses were determined by gravimetry. In method A partial losses associated with each step of drug administration were also determined. Results: Significant drug losses were measured (4–38%). Only methods A (crushing–beaker–syringe–water–NGT) and B (crushing–water–syringe–NGT) were suitable for administration of all tested dosage forms. Method B proved the most effective for all kinds of tablets and C/GR (p < 0.05) and tended to be more effective also for C/ER (p = 0.052) compared to method A. C/P showed minimal losses for both tested methods (B and E). Flushing of the drug through NGT causes major losses during drug administration compared to crushing and transfer (p < 0.05). All methods for intact pellets (C–E) were found inappropriate for clinical practice due to NGT clogging. Conclusions: Choosing a suitable administration method can significantly affect the amount of drugs delivered through NGT.
ER  -

RUZSÍKOVÁ, Adriána; Lenka SOUČKOVÁ; Pavel SUK; Radka OPATŘILOVÁ; Martina KEJDUŠOVÁ a Vladimír ŠRÁMEK. Quantitative analysis of drug losses administered via nasogastric tube - In vitro study. \textit{International Journal of Pharmaceutics}. Amsterdam: Elsevier Science BV, 2015, roč.~478, č.~1, s.~368-371. ISSN~0378-5173. Dostupné z: https://doi.org/10.1016/j.ijpharm.2014.11.065.

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