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@inproceedings{1213453,
author = {Řemínek, Roman and Glatz, Zdeněk and Thormann, Wolfgang},
address = {Brno},
booktitle = {11 th International Interdisciplinary Meeting on Bioanalysis CECE 2014},
editor = {F/ Foret},
keywords = {Kapilární elektroforéza; Enantioselektivní separace; Cytochrom P450; CYP3A4; Ketamin},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Brno},
isbn = {978-80-904959-2-0},
pages = {231-232},
publisher = {Institute of Analytical Chemistry AS CR, v. v. i., Brno, Česká republika,},
title = {Kinetic Study OF Ketamine N-Demethylation Mediated by On-Line Enantioselective Capillary Electrophoresis Method},
year = {2014}
}
TY - JOUR
ID - 1213453
AU - Řemínek, Roman - Glatz, Zdeněk - Thormann, Wolfgang
PY - 2014
TI - Kinetic Study OF Ketamine N-Demethylation Mediated by On-Line Enantioselective Capillary Electrophoresis Method
PB - Institute of Analytical Chemistry AS CR, v. v. i., Brno, Česká republika,
CY - Brno
SN - 9788090495920
KW - Kapilární elektroforéza
KW - Enantioselektivní separace
KW - Cytochrom P450
KW - CYP3A4
KW - Ketamin
N2 - Enantioselective discrimination is an important phenomenon influencing pharmacokinetics and pharmacodynamics of chiral drugs in humans and animals. Metabolism appraisal of single enantiomers of every drug candidate compound thus constitutes the inseparable part of LADME/tox screening. Capillary electrophoresis represents a promising technique in the field of in vitro enzyme assays due to miniscule sample consumption, simple implementation of chiral separations and high-throughput by automation. An optimized and economical capillary electrophoretic method for on-line studies of the enantioselective drug metabolism mediated by cytochrome P450 3A4 enzyme (CYP3A4) is introduced.
ER -
ŘEMÍNEK, Roman, Zdeněk GLATZ a Wolfgang THORMANN. Kinetic Study OF Ketamine N-Demethylation Mediated by On-Line Enantioselective Capillary Electrophoresis Method. In F/ Foret. \textit{11 th International Interdisciplinary Meeting on Bioanalysis CECE 2014}. Brno: Institute of Analytical Chemistry AS CR, v. v. i., Brno, Česká republika,, 2014, s.~231-232. ISBN~978-80-904959-2-0.
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