Disruption of Resting Functional Connectivity in Alzheimer's
Patients and At-Risk Subjects

J 2014

Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects

KRAJČOVIČOVÁ, Lenka, Radek MAREČEK, Michal MIKL a Irena REKTOROVÁ

Základní údaje

Originální název

Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects

Autoři

KRAJČOVIČOVÁ, Lenka (703 Slovensko, domácí), Radek MAREČEK (203 Česká republika, domácí), Michal MIKL (203 Česká republika, domácí) a Irena REKTOROVÁ (203 Česká republika, garant, domácí)

Vydání

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, NEW YORK, SPRINGER, 2014, 1528-4042

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.059

Kód RIV

RIV/00216224:14740/14:00074325

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1007/s11910-014-0491-3

UT WoS

000342073900008

Klíčová slova anglicky

Functional connectivity; fMRI; Resting state; Resting state networks; Default mode network; Alzheimer's disease; Mild cognitive impairment

Štítky

kontrola MP, MP, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 3. 2015 06:56, Martina Prášilová

Anotace

V originále

The resting brain exhibits continuous intrinsic activity, which is correlated between groups of regions forming resting state networks. Evaluating resting connectivity is a popular approach for studying brain diseases. Several hundred studies are now available that address integrity of resting connectivity in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), as well as preclinical at-risk subjects. Most studies focus on the default mode network, a system of specific brain areas showing strong connected resting activity that attenuates during goal-directed behavior. The extent of intrinsic brain activity tends to be strongly correlated with cognitive processes and is specifically disrupted in AD and MCI patients and at-risk subjects, with changes seeming to evolve during the transition between the disease stages. In this study, we review the current findings in default mode network and other resting state network studies in AD and MCI patients and at-risk subjects as assessed by resting state functional magnetic resonance imaging.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

GA14-33143S, projekt VaV

Název: Vliv fyziologických procesů na reliabilitu a časovou proměnlivost konektivity v lidském mozku měřené pomocí fMRI

Investor: Grantová agentura ČR, Vliv fyziologických procesů na reliabilitu a časovou proměnlivost konektivity v lidském mozku měřené pomocí fMRI

Citovat

KRAJČOVIČOVÁ, Lenka, Radek MAREČEK, Michal MIKL a Irena REKTOROVÁ. Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects. CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS. NEW YORK: SPRINGER, 2014, roč. 14, č. 10, s. "nestránkované", 7 s. ISSN 1528-4042. Dostupné z: https://dx.doi.org/10.1007/s11910-014-0491-3.

@article{1216651,
   author = {Krajčovičová, Lenka and Mareček, Radek and Mikl, Michal and Rektorová, Irena},
   article_location = {NEW YORK},
   article_number = {10},
   doi = {http://dx.doi.org/10.1007/s11910-014-0491-3},
   keywords = {Functional connectivity; fMRI; Resting state; Resting state networks; Default mode network; Alzheimer's disease; Mild cognitive impairment},
   language = {eng},
   issn = {1528-4042},
   journal = {CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS},
   title = {Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects},
   url = {http://link.springer.com/article/10.1007%2Fs11910-014-0491-3},
   volume = {14},
   year = {2014}
}

TY  - JOUR
ID  - 1216651
AU  - Krajčovičová, Lenka - Mareček, Radek - Mikl, Michal - Rektorová, Irena
PY  - 2014
TI  - Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects
JF  - CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
VL  - 14
IS  - 10
SP  - "nestránkované"
EP  - "nestránkované"
PB  - SPRINGER
SN  - 15284042
KW  - Functional connectivity
KW  - fMRI
KW  - Resting state
KW  - Resting state networks
KW  - Default mode network
KW  - Alzheimer's disease
KW  - Mild cognitive impairment
UR  - http://link.springer.com/article/10.1007%2Fs11910-014-0491-3
L2  - http://link.springer.com/article/10.1007%2Fs11910-014-0491-3
N2  - The resting brain exhibits continuous intrinsic activity, which is correlated between groups of regions forming resting state networks. Evaluating resting connectivity is a popular approach for studying brain diseases. Several hundred studies are now available that address integrity of resting connectivity in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), as well as preclinical at-risk subjects. Most studies focus on the default mode network, a system of specific brain areas showing strong connected resting activity that attenuates during goal-directed behavior. The extent of intrinsic brain activity tends to be strongly correlated with cognitive processes and is specifically disrupted in AD and MCI patients and at-risk subjects, with changes seeming to evolve during the transition between the disease stages. In this study, we review the current findings in default mode network and other resting state network studies in AD and MCI patients and at-risk subjects as assessed by resting state functional magnetic resonance imaging.
ER  -

KRAJČOVIČOVÁ, Lenka, Radek MAREČEK, Michal MIKL a Irena REKTOROVÁ. Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects. \textit{CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS}. NEW YORK: SPRINGER, 2014, roč.~14, č.~10, s.~''nestránkované'', 7 s. ISSN~1528-4042. Dostupné z: https://dx.doi.org/10.1007/s11910-014-0491-3.

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