REKTOROVÁ, Irena, Roberta BIUNDO, Radek MAREČEK, Luca WEIS, Dag AARSLAND a Angelo ANTONINI. Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients. Plos one, SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2014, roč. 9, č. 1, s. "nestránkované". ISSN 1932-6203. doi:10.1371/journal.pone.0085595.
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Základní údaje
Originální název Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients
Autoři REKTOROVÁ, Irena (203 Česká republika, garant, domácí), Roberta BIUNDO (380 Itálie), Radek MAREČEK (203 Česká republika, domácí), Luca WEIS (380 Itálie), Dag AARSLAND (752 Švédsko) a Angelo ANTONINI (380 Itálie).
Vydání Plos one, SAN FRANCISCO, PUBLIC LIBRARY SCIENCE, 2014, 1932-6203.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 3. Medical and Health Sciences
Stát vydavatele Spojené státy americké
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 3.234
Kód RIV RIV/00216224:14740/14:00078359
Organizační jednotka Středoevropský technologický institut
Doi http://dx.doi.org/10.1371/journal.pone.0085595
UT WoS 000330244500080
Klíčová slova anglicky FRONTAL ASSESSMENT BATTERY; ITALIAN POPULATION-SAMPLE; SOURCE-BASED MORPHOMETRY; DEFAULT MODE NETWORK; DIAGNOSTIC-CRITERIA; ALZHEIMERS-DISEASE; NORMATIVE VALUES; CEREBRAL ATROPHY; LEWY BODIES; DEMENTIA
Štítky kontrola MP, MP, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Martina Prášilová, učo 342282. Změněno: 12. 3. 2015 07:12.
Anotace
Background: Cortical changes associated with cognitive decline in Parkinson's disease (PD) are not fully explored and require investigations with established diagnostic classification criteria. Objective: We used MRI source-based morphometry to evaluate specific differences in grey matter volume patterns across 4 groups of subjects: healthy controls (HC), PD with normal cognition (PD-NC), PD with mild cognitive impairment (MCI-PD) and PD with dementia (PDD). Methods: We examined 151 consecutive subjects: 25 HC, 75 PD-NC, 29 MCI-PD, and 22 PDD at an Italian and Czech movement disorder centre. Operational diagnostic criteria were applied to classify MCI-PD and PDD. All structural MRI images were processed together in the Czech centre. The spatial independent component analysis was used to assess group differences of local grey matter volume. Results: We identified two independent patterns of grey matter volume deviations: a) Reductions in the hippocampus and temporal lobes; b) Decreases in fronto-parietal regions and increases in the midbrain/cerebellum. Both patterns differentiated PDD from all other groups and correlated with visuospatial deficits and letter verbal fluency, respectively. Only the second pattern additionally differentiated PD-NC from HC. Conclusion: Grey matter changes in PDD involve areas associated with Alzheimer-like pathology while fronto-parietal abnormalities are possibly an early marker of PD cognitive decline. These findings are consistent with a non-linear cognitive progression in PD.
Návaznosti
ED1.1.00/02.0068, projekt VaVNázev: CEITEC - central european institute of technology
VytisknoutZobrazeno: 16. 10. 2019 06:54