Grey Matter Changes in Cognitively Impaired Parkinson's Disease
Patients

J 2014

Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients

REKTOROVÁ, Irena; Roberta BIUNDO; Radek MAREČEK; Luca WEIS; Dag AARSLAND et al.

Základní údaje

Originální název

Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients

Autoři

REKTOROVÁ, Irena; Roberta BIUNDO; Radek MAREČEK; Luca WEIS; Dag AARSLAND a Angelo ANTONINI

Vydání

Plos one, SAN FRANCISCO, PUBLIC LIBRARY SCIENCE, 2014, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.234

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/14:00078359

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

FRONTAL ASSESSMENT BATTERY; ITALIAN POPULATION-SAMPLE; SOURCE-BASED MORPHOMETRY; DEFAULT MODE NETWORK; DIAGNOSTIC-CRITERIA; ALZHEIMERS-DISEASE; NORMATIVE VALUES; CEREBRAL ATROPHY; LEWY BODIES; DEMENTIA

Štítky

kontrola MP, MP, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 3. 2015 07:12, Martina Prášilová

Anotace

V originále

Background: Cortical changes associated with cognitive decline in Parkinson's disease (PD) are not fully explored and require investigations with established diagnostic classification criteria. Objective: We used MRI source-based morphometry to evaluate specific differences in grey matter volume patterns across 4 groups of subjects: healthy controls (HC), PD with normal cognition (PD-NC), PD with mild cognitive impairment (MCI-PD) and PD with dementia (PDD). Methods: We examined 151 consecutive subjects: 25 HC, 75 PD-NC, 29 MCI-PD, and 22 PDD at an Italian and Czech movement disorder centre. Operational diagnostic criteria were applied to classify MCI-PD and PDD. All structural MRI images were processed together in the Czech centre. The spatial independent component analysis was used to assess group differences of local grey matter volume. Results: We identified two independent patterns of grey matter volume deviations: a) Reductions in the hippocampus and temporal lobes; b) Decreases in fronto-parietal regions and increases in the midbrain/cerebellum. Both patterns differentiated PDD from all other groups and correlated with visuospatial deficits and letter verbal fluency, respectively. Only the second pattern additionally differentiated PD-NC from HC. Conclusion: Grey matter changes in PDD involve areas associated with Alzheimer-like pathology while fronto-parietal abnormalities are possibly an early marker of PD cognitive decline. These findings are consistent with a non-linear cognitive progression in PD.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

REKTOROVÁ, Irena; Roberta BIUNDO; Radek MAREČEK; Luca WEIS; Dag AARSLAND a Angelo ANTONINI. Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients. Plos one. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2014, roč. 9, č. 1, s. "nestránkované", 8 s. ISSN 1932-6203. Dostupné z: https://doi.org/10.1371/journal.pone.0085595.

@article{1216656,
   author = {Rektorová, Irena and Biundo, Roberta and Mareček, Radek and Weis, Luca and Aarsland, Dag and Antonini, Angelo},
   article_location = {SAN FRANCISCO},
   article_number = {1},
   doi = {https://doi.org/10.1371/journal.pone.0085595},
   keywords = {FRONTAL ASSESSMENT BATTERY; ITALIAN POPULATION-SAMPLE; SOURCE-BASED MORPHOMETRY; DEFAULT MODE NETWORK; DIAGNOSTIC-CRITERIA; ALZHEIMERS-DISEASE; NORMATIVE VALUES; CEREBRAL ATROPHY; LEWY BODIES; DEMENTIA},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients},
   url = {http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF},
   volume = {9},
   year = {2014}
}

TY  - JOUR
ID  - 1216656
AU  - Rektorová, Irena - Biundo, Roberta - Mareček, Radek - Weis, Luca - Aarsland, Dag - Antonini, Angelo
PY  - 2014
TI  - Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients
JF  - Plos one
VL  - 9
IS  - 1
SP  - "nestránkované"
EP  - "nestránkované"
PB  - PUBLIC LIBRARY SCIENCE
SN  - 19326203
KW  - FRONTAL ASSESSMENT BATTERY
KW  - ITALIAN POPULATION-SAMPLE
KW  - SOURCE-BASED MORPHOMETRY
KW  - DEFAULT MODE NETWORK
KW  - DIAGNOSTIC-CRITERIA
KW  - ALZHEIMERS-DISEASE
KW  - NORMATIVE VALUES
KW  - CEREBRAL ATROPHY
KW  - LEWY BODIES
KW  - DEMENTIA
UR  - http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF
L2  - http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF
N2  - Background: Cortical changes associated with cognitive decline in Parkinson's disease (PD) are not fully explored and require investigations with established diagnostic classification criteria. Objective: We used MRI source-based morphometry to evaluate specific differences in grey matter volume patterns across 4 groups of subjects: healthy controls (HC), PD with normal cognition (PD-NC), PD with mild cognitive impairment (MCI-PD) and PD with dementia (PDD). Methods: We examined 151 consecutive subjects: 25 HC, 75 PD-NC, 29 MCI-PD, and 22 PDD at an Italian and Czech movement disorder centre. Operational diagnostic criteria were applied to classify MCI-PD and PDD. All structural MRI images were processed together in the Czech centre. The spatial independent component analysis was used to assess group differences of local grey matter volume. Results: We identified two independent patterns of grey matter volume deviations: a) Reductions in the hippocampus and temporal lobes; b) Decreases in fronto-parietal regions and increases in the midbrain/cerebellum. Both patterns differentiated PDD from all other groups and correlated with visuospatial deficits and letter verbal fluency, respectively. Only the second pattern additionally differentiated PD-NC from HC. Conclusion: Grey matter changes in PDD involve areas associated with Alzheimer-like pathology while fronto-parietal abnormalities are possibly an early marker of PD cognitive decline. These findings are consistent with a non-linear cognitive progression in PD.
ER  -

REKTOROVÁ, Irena; Roberta BIUNDO; Radek MAREČEK; Luca WEIS; Dag AARSLAND a Angelo ANTONINI. Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients. \textit{Plos one}. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2014, roč.~9, č.~1, s.~''nestránkované'', 8 s. ISSN~1932-6203. Dostupné z: https://doi.org/10.1371/journal.pone.0085595.

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