Diagnostic and Prognostic Utility of Neutrophil
Gelatinase-Associated Lipocalin (NGAL) in Patients with
Cardiovascular Diseases - Review

J 2014

Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review

HELÁNOVÁ, Kateřina; Jindřich ŠPINAR a Jiří PAŘENICA

Základní údaje

Originální název

Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review

Autoři

HELÁNOVÁ, Kateřina; Jindřich ŠPINAR a Jiří PAŘENICA

Vydání

Kidney and Blood Pressure Research, Basel, Karger, 2014, 1420-4096

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.123

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00078559

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

NGAL; Biomarker; Cardiovascular disease; Prognosis; Diagnosis; AKI

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 4. 2015 13:54, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

NGAL (neutrophil gelatinase-associated lipocalin) is an acute phase protein, participating in antibacterial immunity. NGAL forms a complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and preventing its degradation. NGAL is freely filtered through the glomerular membrane and reabsorbed by endocytosis in the proximal tubule. NGAL detected in urine is produced mainly in the distal nephron. Elevated serum and urine NGAL allows diagnosis of acute kidney injury approximately 24 hours earlier than plasma creatinine concentration. Increased levels of NGAL were detected in patients with acute myocardial infarction, heart failure or stroke and were demonstrated to be strong predictors of adverse prognosis.

Návaznosti

MUNI/A/1012/2013, interní kód MU

Název: Diagnostika akutní myokarditidy mimikující akutní infarkt myokardu s ST elevacemi

Investor: Masarykova univerzita, Diagnostika akutní myokarditidy mimikující akutní infarkt myokardu s ST elevacemi, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

HELÁNOVÁ, Kateřina; Jindřich ŠPINAR a Jiří PAŘENICA. Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review. Kidney and Blood Pressure Research. Basel: Karger, 2014, roč. 39, č. 6, s. 623-629. ISSN 1420-4096. Dostupné z: https://doi.org/10.1159/000368474.

@article{1217665,
   author = {Helánová, Kateřina and Špinar, Jindřich and Pařenica, Jiří},
   article_location = {Basel},
   article_number = {6},
   doi = {https://doi.org/10.1159/000368474},
   keywords = {NGAL; Biomarker; Cardiovascular disease; Prognosis; Diagnosis; AKI},
   language = {eng},
   issn = {1420-4096},
   journal = {Kidney and Blood Pressure Research},
   title = {Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review},
   volume = {39},
   year = {2014}
}

TY  - JOUR
ID  - 1217665
AU  - Helánová, Kateřina - Špinar, Jindřich - Pařenica, Jiří
PY  - 2014
TI  - Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review
JF  - Kidney and Blood Pressure Research
VL  - 39
IS  - 6
SP  - 623-629
EP  - 623-629
PB  - Karger
SN  - 14204096
KW  - NGAL
KW  - Biomarker
KW  - Cardiovascular disease
KW  - Prognosis
KW  - Diagnosis
KW  - AKI
N2  - NGAL (neutrophil gelatinase-associated lipocalin) is an acute phase protein, participating in antibacterial immunity. NGAL forms a complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and preventing its degradation. NGAL is freely filtered through the glomerular membrane and reabsorbed by endocytosis in the proximal tubule. NGAL detected in urine is produced mainly in the distal nephron. Elevated serum and urine NGAL allows diagnosis of acute kidney injury approximately 24 hours earlier than plasma creatinine concentration. Increased levels of NGAL were detected in patients with acute myocardial infarction, heart failure or stroke and were demonstrated to be strong predictors of adverse prognosis.
ER  -

HELÁNOVÁ, Kateřina; Jindřich ŠPINAR a Jiří PAŘENICA. Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review. \textit{Kidney and Blood Pressure Research}. Basel: Karger, 2014, roč.~39, č.~6, s.~623-629. ISSN~1420-4096. Dostupné z: https://doi.org/10.1159/000368474.

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