| HELÁNOVÁ, Kateřina, Jindřich ŠPINAR a Jiří PAŘENICA. Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review. Kidney and Blood Pressure Research. Basel: Karger, 2014, roč. 39, č. 6, s. 623-629. ISSN 1420-4096. Dostupné z: https://dx.doi.org/10.1159/000368474. |
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@article{1217665,
author = {Helánová, Kateřina and Špinar, Jindřich and Pařenica, Jiří},
article_location = {Basel},
article_number = {6},
doi = {http://dx.doi.org/10.1159/000368474},
keywords = {NGAL; Biomarker; Cardiovascular disease; Prognosis; Diagnosis; AKI},
language = {eng},
issn = {1420-4096},
journal = {Kidney and Blood Pressure Research},
title = {Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review},
volume = {39},
year = {2014}
}
TY - JOUR
ID - 1217665
AU - Helánová, Kateřina - Špinar, Jindřich - Pařenica, Jiří
PY - 2014
TI - Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review
JF - Kidney and Blood Pressure Research
VL - 39
IS - 6
SP - 623-629
EP - 623-629
PB - Karger
SN - 14204096
KW - NGAL
KW - Biomarker
KW - Cardiovascular disease
KW - Prognosis
KW - Diagnosis
KW - AKI
N2 - NGAL (neutrophil gelatinase-associated lipocalin) is an acute phase protein, participating in antibacterial immunity. NGAL forms a complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and preventing its degradation. NGAL is freely filtered through the glomerular membrane and reabsorbed by endocytosis in the proximal tubule. NGAL detected in urine is produced mainly in the distal nephron. Elevated serum and urine NGAL allows diagnosis of acute kidney injury approximately 24 hours earlier than plasma creatinine concentration. Increased levels of NGAL were detected in patients with acute myocardial infarction, heart failure or stroke and were demonstrated to be strong predictors of adverse prognosis.
ER -
HELÁNOVÁ, Kateřina, Jindřich ŠPINAR a Jiří PAŘENICA. Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review. \textit{Kidney and Blood Pressure Research}. Basel: Karger, 2014, roč.~39, č.~6, s.~623-629. ISSN~1420-4096. Dostupné z: https://dx.doi.org/10.1159/000368474.
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