ČULEN, Martin, Paweł K. TUSZYŃSKI, Sebastian POLAK, Renata JACHOWICZ, Aleksander MENDYK a Jiří DOHNAL. Development of In Vitro-In Vivo Correlation/Relationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from "Golem'': A Novel Apparatus. BioMed Research International. New York: Hindawi Publishing Corporation, 2015, roč. 2015, č. 328628, s. 1-13. ISSN 2314-6133. Dostupné z: https://dx.doi.org/10.1155/2015/328628. |
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@article{1218656, author = {Čulen, Martin and Tuszyński, Paweł K. and Polak, Sebastian and Jachowicz, Renata and Mendyk, Aleksander and Dohnal, Jiří}, article_location = {New York}, article_number = {328628}, doi = {http://dx.doi.org/10.1155/2015/328628}, keywords = {COA REDUCTASE INHIBITORS; ATORVASTATIN; PHARMACOKINETICS; BIOAVAILABILITY; STEP}, language = {eng}, issn = {2314-6133}, journal = {BioMed Research International}, title = {Development of In Vitro-In Vivo Correlation/Relationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from "Golem'': A Novel Apparatus}, volume = {2015}, year = {2015} }
TY - JOUR ID - 1218656 AU - Čulen, Martin - Tuszyński, Paweł K. - Polak, Sebastian - Jachowicz, Renata - Mendyk, Aleksander - Dohnal, Jiří PY - 2015 TI - Development of In Vitro-In Vivo Correlation/Relationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from "Golem'': A Novel Apparatus JF - BioMed Research International VL - 2015 IS - 328628 SP - 1-13 EP - 1-13 PB - Hindawi Publishing Corporation SN - 23146133 KW - COA REDUCTASE INHIBITORS KW - ATORVASTATIN KW - PHARMACOKINETICS KW - BIOAVAILABILITY KW - STEP N2 - Different batches of atorvastatin, represented by two immediate release formulation designs, were studied using a novel dynamic dissolution apparatus, simulating stomach and small intestine. A universal dissolution method was employed which simulated the physiology of human gastrointestinal tract, including the precise chyme transit behavior and biorelevant conditions. The multicompartmental dissolution data allowed direct observation and qualitative discrimination of the differences resulting from highly pH dependent dissolution behavior of the tested batches. Further evaluation of results was performed using IVIVC/IVIVR development. While satisfactory correlation could not be achieved using a conventional deconvolution based-model, promising results were obtained through the use of a nonconventional approach exploiting the complex compartmental dissolution data. ER -
ČULEN, Martin, Paweł K. TUSZY$\backslash$'NSKI, Sebastian POLAK, Renata JACHOWICZ, Aleksander MENDYK a Jiří DOHNAL. Development of In Vitro-In Vivo Correlation/Relationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from ''Golem'': A Novel Apparatus. \textit{BioMed Research International}. New York: Hindawi Publishing Corporation, 2015, roč.~2015, č.~328628, s.~1-13. ISSN~2314-6133. Dostupné z: https://dx.doi.org/10.1155/2015/328628.
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