Increased Pulsatility of the Intracranial Blood Flow Spectral
Waveform on Transcranial Doppler Does Not Point to Peripheral
Arterial Disease in Stroke Patients

J 2015

Increased Pulsatility of the Intracranial Blood Flow Spectral Waveform on Transcranial Doppler Does Not Point to Peripheral Arterial Disease in Stroke Patients

BARLINN, Kristian, Stanislava KOLIESKOVÁ, Reza Bavarsad SHAHRIPOUR, Jessica KEPPLINGER, Amelia K. BOEHME et. al.

Základní údaje

Originální název

Increased Pulsatility of the Intracranial Blood Flow Spectral Waveform on Transcranial Doppler Does Not Point to Peripheral Arterial Disease in Stroke Patients

Autoři

BARLINN, Kristian (840 Spojené státy), Stanislava KOLIESKOVÁ (703 Slovensko, garant, domácí), Reza Bavarsad SHAHRIPOUR (840 Spojené státy), Jessica KEPPLINGER (276 Německo), Amelia K. BOEHME (840 Spojené státy), Timo SIEPMANN (276 Německo), Volker PUETZ (276 Německo), Ulf BODECHTEL (276 Německo), William D. JORDAN (840 Spojené státy) a Andrei V. ALEXANDROV (840 Spojené státy)

Vydání

Journal of Stroke and Cerebrovascular Diseases, Amsterdam, Elsevier Science Inc. 2015, 1052-3057

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.599

Kód RIV

RIV/00216224:14110/15:00082309

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2014.08.014

UT WoS

000346733700041

Klíčová slova anglicky

Stroke; peripheral arterial disease; intracranial disease; transcranial Doppler

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 7. 2015 13:49, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Background: Peripheral arterial disease (PAD) is common in patients with acute cerebral ischemia. Indexes of resistance derived from the systolic and diastolic velocities are routinely used in diagnostic transcranial Doppler (TCD) to detect intracranial arterial disease. We sought to explore whether these indexes can predict the presence of PAD in acute cerebral ischemia. Methods: We prospectively evaluated consecutive patients with acute cerebral ischemia. On TCD, peak-systolic and end-diastolic velocities in both middle cerebral and basilar arteries were manually measured to calculate pulsatility index (PI) and resistance index (RI). Increased resistance was defined as PI equal to 1.2 or more and RI equal to .75 or more. Ankle-brachial index (ABI) measurements were performed and an ABI equal to .9 or more was considered predictive of definite PAD. Results: We included 95 patients (45 male, 50 female) aged 66 6 9 years with a median National Institutes Health Stroke Scale score of 3 (interquartile range, 8) points. The ABI was abnormal and consistent with definite PAD in 24 of 95 (25.3%; 95% confidence interval [ CI], 16.4-4.2) patients. Increased PI did not differ among patients with and without PAD (20.8% vs. 28.2%, P =.60). Only 1 patient with PAD had increased RI as opposed to 4 patients without PAD (4.2% vs. 5.6%, P = 1.0). Increased PI was not found to be an independent predictor of PAD (odds ratio [ OR],.68; 95% CI,.22-2.12; P =.51). Increases in both PI and RI independently predicted arterial hypertension (OR, 1.62; 95% CI, 1.19-2.21; P =.002 and OR, 3.20; 95% CI, 1.51-6.77; P=.002, respectively). Conclusions: Our findings indicate that PAD cannot be inferred from intracranial flow parameters predictive of arterial disease and risk factors such as hypertension among patients with acute cerebral ischemia. Key Words: Stroke-peripheral arterial disease-intracranial disease-transcranial Doppler.

Citovat

BARLINN, Kristian, Stanislava KOLIESKOVÁ, Reza Bavarsad SHAHRIPOUR, Jessica KEPPLINGER, Amelia K. BOEHME, Timo SIEPMANN, Volker PUETZ, Ulf BODECHTEL, William D. JORDAN a Andrei V. ALEXANDROV. Increased Pulsatility of the Intracranial Blood Flow Spectral Waveform on Transcranial Doppler Does Not Point to Peripheral Arterial Disease in Stroke Patients. Journal of Stroke and Cerebrovascular Diseases. Amsterdam: Elsevier Science Inc., 2015, roč. 24, č. 1, s. 189-195. ISSN 1052-3057. Dostupné z: https://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2014.08.014.

@article{1218800,
   author = {Barlinn, Kristian and Koliesková, Stanislava and Shahripour, Reza Bavarsad and Kepplinger, Jessica and Boehme, Amelia K. and Siepmann, Timo and Puetz, Volker and Bodechtel, Ulf and Jordan, William D. and Alexandrov, Andrei V.},
   article_location = {Amsterdam},
   article_number = {1},
   doi = {http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2014.08.014},
   keywords = {Stroke; peripheral arterial disease; intracranial disease; transcranial Doppler},
   language = {eng},
   issn = {1052-3057},
   journal = {Journal of Stroke and Cerebrovascular Diseases},
   title = {Increased Pulsatility of the Intracranial Blood Flow Spectral Waveform on Transcranial Doppler Does Not Point to Peripheral Arterial Disease in Stroke Patients},
   volume = {24},
   year = {2015}
}

TY  - JOUR
ID  - 1218800
AU  - Barlinn, Kristian - Koliesková, Stanislava - Shahripour, Reza Bavarsad - Kepplinger, Jessica - Boehme, Amelia K. - Siepmann, Timo - Puetz, Volker - Bodechtel, Ulf - Jordan, William D. - Alexandrov, Andrei V.
PY  - 2015
TI  - Increased Pulsatility of the Intracranial Blood Flow Spectral Waveform on Transcranial Doppler Does Not Point to Peripheral Arterial Disease in Stroke Patients
JF  - Journal of Stroke and Cerebrovascular Diseases
VL  - 24
IS  - 1
SP  - 189-195
EP  - 189-195
PB  - Elsevier Science Inc.
SN  - 10523057
KW  - Stroke
KW  - peripheral arterial disease
KW  - intracranial disease
KW  - transcranial Doppler
N2  - Background: Peripheral arterial disease (PAD) is common in patients with acute cerebral ischemia. Indexes of resistance derived from the systolic and diastolic velocities are routinely used in diagnostic transcranial Doppler (TCD) to detect intracranial arterial disease. We sought to explore whether these indexes can predict the presence of PAD in acute cerebral ischemia. Methods: We prospectively evaluated consecutive patients with acute cerebral ischemia. On TCD, peak-systolic and end-diastolic velocities in both middle cerebral and basilar arteries were manually measured to calculate pulsatility index (PI) and resistance index (RI). Increased resistance was defined as PI equal to 1.2 or more and RI equal to .75 or more. Ankle-brachial index (ABI) measurements were performed and an ABI equal to .9 or more was considered predictive of definite PAD. Results: We included 95 patients (45 male, 50 female) aged 66 6 9 years with a median National Institutes Health Stroke Scale score of 3 (interquartile range, 8) points. The ABI was abnormal and consistent with definite PAD in 24 of 95 (25.3%; 95% confidence interval [ CI], 16.4-4.2) patients. Increased PI did not differ among patients with and without PAD (20.8% vs. 28.2%, P =.60). Only 1 patient with PAD had increased RI as opposed to 4 patients without PAD (4.2% vs. 5.6%, P = 1.0). Increased PI was not found to be an independent predictor of PAD (odds ratio [ OR],.68; 95% CI,.22-2.12; P =.51). Increases in both PI and RI independently predicted arterial hypertension (OR, 1.62; 95% CI, 1.19-2.21; P =.002 and OR, 3.20; 95% CI, 1.51-6.77; P=.002, respectively). Conclusions: Our findings indicate that PAD cannot be inferred from intracranial flow parameters predictive of arterial disease and risk factors such as hypertension among patients with acute cerebral ischemia. Key Words: Stroke-peripheral arterial disease-intracranial disease-transcranial Doppler.
ER  -

BARLINN, Kristian, Stanislava KOLIESKOVÁ, Reza Bavarsad SHAHRIPOUR, Jessica KEPPLINGER, Amelia K. BOEHME, Timo SIEPMANN, Volker PUETZ, Ulf BODECHTEL, William D. JORDAN a Andrei V. ALEXANDROV. Increased Pulsatility of the Intracranial Blood Flow Spectral Waveform on Transcranial Doppler Does Not Point to Peripheral Arterial Disease in Stroke Patients. \textit{Journal of Stroke and Cerebrovascular Diseases}. Amsterdam: Elsevier Science Inc., 2015, roč.~24, č.~1, s.~189-195. ISSN~1052-3057. Dostupné z: https://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2014.08.014.

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