Pilot study of sex differences in QTc intervals of heart
transplant recipients

J 2014

Pilot study of sex differences in QTc intervals of heart transplant recipients

NOVOTNÝ, Tomáš; Pavel LEINVEBER; Katerina HNATKOVA; Tereza REICHLOVA; Magdalena MATEJKOVA et al.

Základní údaje

Originální název

Pilot study of sex differences in QTc intervals of heart transplant recipients

Autoři

Vydání

Journal of Electrocardiology, Philadelphia, Churchill Livingstone Inc Medical Publishers, 2014, 0022-0736

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.361

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00078947

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Cardiac repolarization; Heart transplantation; Sex differences

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 2. 2015 12:31, Soňa Böhmová

Anotace

V originále

Background: Repolarization processes in female and male are different. This study provided pilot data on automatic measurements of QT intervals in heart transplant (HT) recipients stratified according to the sex of the recipient and the donor. Methods and results: The following groups were analyzed: Group A-20 males with male heart, group B-14 females with male heart, group C-13 females with female heart, group D-11 males with female heart, group E-20 healthy males, and group F-20 healthy females. Twelve-lead electrocardiograms were digitally captured during autonomic provocative test of five postural 8-minute stages supine, unsupported sitting, supine, unsupported standing, and supine. Fridericia formula was used for heart rate correction together with a generic correction for QT/RR hysteresis. Neither female nor male HT recipients exhibit any differences in QTc interval duration related to the sex of the donor. There was, however, a trend towards longer QTc intervals in female HT recipients compared to male HT recipients irrespective of the sex of the donor. The QTc differences between healthy control females and males were highly statistically significant proving the assay sensitivity of the study. Conclusion: The available pilot data suggest that in HT patients, the sex of the donor has little influence on the QTc interval of the transplanted heart.

Citovat

NOVOTNÝ, Tomáš; Pavel LEINVEBER; Katerina HNATKOVA; Tereza REICHLOVA; Magdalena MATEJKOVA; Martina ŠIŠÁKOVÁ; Jan KREJČÍ; Petr HUDE; Helena BEDÁŇOVÁ; Petr NĚMEC; Jindřich ŠPINAR; Lenka ŠPINAROVÁ a Marek MALIK. Pilot study of sex differences in QTc intervals of heart transplant recipients. Journal of Electrocardiology. Philadelphia: Churchill Livingstone Inc Medical Publishers, 2014, roč. 47, č. 6, s. 863-868. ISSN 0022-0736. Dostupné z: https://doi.org/10.1016/j.jelectrocard.2014.07.015.

@article{1220202,
   author = {Novotný, Tomáš and Leinveber, Pavel and Hnatkova, Katerina and Reichlova, Tereza and Matejkova, Magdalena and Šišáková, Martina and Krejčí, Jan and Hude, Petr and Bedáňová, Helena and Němec, Petr and Špinar, Jindřich and Špinarová, Lenka and Malik, Marek},
   article_location = {Philadelphia},
   article_number = {6},
   doi = {https://doi.org/10.1016/j.jelectrocard.2014.07.015},
   keywords = {Cardiac repolarization; Heart transplantation; Sex differences},
   language = {eng},
   issn = {0022-0736},
   journal = {Journal of Electrocardiology},
   title = {Pilot study of sex differences in QTc intervals of heart transplant recipients},
   volume = {47},
   year = {2014}
}

TY  - JOUR
ID  - 1220202
AU  - Novotný, Tomáš - Leinveber, Pavel - Hnatkova, Katerina - Reichlova, Tereza - Matejkova, Magdalena - Šišáková, Martina - Krejčí, Jan - Hude, Petr - Bedáňová, Helena - Němec, Petr - Špinar, Jindřich - Špinarová, Lenka - Malik, Marek
PY  - 2014
TI  - Pilot study of sex differences in QTc intervals of heart transplant recipients
JF  - Journal of Electrocardiology
VL  - 47
IS  - 6
SP  - 863-868
EP  - 863-868
PB  - Churchill Livingstone Inc Medical Publishers
SN  - 00220736
KW  - Cardiac repolarization
KW  - Heart transplantation
KW  - Sex differences
N2  - Background: Repolarization processes in female and male are different. This study provided pilot data on automatic measurements of QT intervals in heart transplant (HT) recipients stratified according to the sex of the recipient and the donor. Methods and results: The following groups were analyzed: Group A-20 males with male heart, group B-14 females with male heart, group C-13 females with female heart, group D-11 males with female heart, group E-20 healthy males, and group F-20 healthy females. Twelve-lead electrocardiograms were digitally captured during autonomic provocative test of five postural 8-minute stages supine, unsupported sitting, supine, unsupported standing, and supine. Fridericia formula was used for heart rate correction together with a generic correction for QT/RR hysteresis. Neither female nor male HT recipients exhibit any differences in QTc interval duration related to the sex of the donor. There was, however, a trend towards longer QTc intervals in female HT recipients compared to male HT recipients irrespective of the sex of the donor. The QTc differences between healthy control females and males were highly statistically significant proving the assay sensitivity of the study. Conclusion: The available pilot data suggest that in HT patients, the sex of the donor has little influence on the QTc interval of the transplanted heart.
ER  -

NOVOTNÝ, Tomáš; Pavel LEINVEBER; Katerina HNATKOVA; Tereza REICHLOVA; Magdalena MATEJKOVA; Martina ŠIŠÁKOVÁ; Jan KREJČÍ; Petr HUDE; Helena BEDÁŇOVÁ; Petr NĚMEC; Jindřich ŠPINAR; Lenka ŠPINAROVÁ a Marek MALIK. Pilot study of sex differences in QTc intervals of heart transplant recipients. \textit{Journal of Electrocardiology}. Philadelphia: Churchill Livingstone Inc Medical Publishers, 2014, roč.~47, č.~6, s.~863-868. ISSN~0022-0736. Dostupné z: https://doi.org/10.1016/j.jelectrocard.2014.07.015.

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