| AUGUSTYNIAK, Justyna, Marzena ZYCHOWICZ, Martyna PODOBINSKA, Tomáš BÁRTA a Leonora BUZANSKA. Reprogramming of somatic cells: possible methods to derive safe, clinical-grade human induced pluripotent stem cells. Acta Neurobiologiae Experimentalis. Warsaw: Nencki Institute of Experimental Biology, 2014, roč. 74, č. 4, s. 373-382. ISSN 0065-1400. |
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@article{1225714,
author = {Augustyniak, Justyna and Zychowicz, Marzena and Podobinska, Martyna and Bárta, Tomáš and Buzanska, Leonora},
article_location = {Warsaw},
article_number = {4},
keywords = {IPS cells; MRNA and miRNA transfection; Protein transduction; Somatic cells reprogramming},
language = {eng},
issn = {0065-1400},
journal = {Acta Neurobiologiae Experimentalis},
title = {Reprogramming of somatic cells: possible methods to derive safe, clinical-grade human induced pluripotent stem cells},
volume = {74},
year = {2014}
}
TY - JOUR
ID - 1225714
AU - Augustyniak, Justyna - Zychowicz, Marzena - Podobinska, Martyna - Bárta, Tomáš - Buzanska, Leonora
PY - 2014
TI - Reprogramming of somatic cells: possible methods to derive safe, clinical-grade human induced pluripotent stem cells
JF - Acta Neurobiologiae Experimentalis
VL - 74
IS - 4
SP - 373-382
EP - 373-382
PB - Nencki Institute of Experimental Biology
SN - 00651400
KW - IPS cells
KW - MRNA and miRNA transfection
KW - Protein transduction
KW - Somatic cells reprogramming
N2 - Derivation of pluripotent stem cells from adult somatic tissues by reprogramming technology has opened new therapeutic possibilities. Current most efficient procedures for derivation of induced pluripotent stem (iPS) cells are based on the viral vectors, which represent the danger of insertional mutagenesis during incorporation of introduced genes into the host genome. To circumvent this problem, the new, safe, non-integrative and non-viral strategies of reprogramming have been developed. In this review we discuss novel DNA-free and viral-free methods of reprogramming to iPS cells including protein transduction, mRNA and microRNA delivery.
ER -
AUGUSTYNIAK, Justyna, Marzena ZYCHOWICZ, Martyna PODOBINSKA, Tomáš BÁRTA a Leonora BUZANSKA. Reprogramming of somatic cells: possible methods to derive safe, clinical-grade human induced pluripotent stem cells. \textit{Acta Neurobiologiae Experimentalis}. Warsaw: Nencki Institute of Experimental Biology, 2014, roč.~74, č.~4, s.~373-382. ISSN~0065-1400.
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