Reprogramming of somatic cells: possible methods to derive
safe, clinical-grade human induced pluripotent stem cells

J 2014

Reprogramming of somatic cells: possible methods to derive safe, clinical-grade human induced pluripotent stem cells

AUGUSTYNIAK, Justyna; Marzena ZYCHOWICZ; Martyna PODOBINSKA; Tomáš BÁRTA; Leonora BUZANSKA et al.

Základní údaje

Originální název

Reprogramming of somatic cells: possible methods to derive safe, clinical-grade human induced pluripotent stem cells

Autoři

AUGUSTYNIAK, Justyna; Marzena ZYCHOWICZ; Martyna PODOBINSKA; Tomáš BÁRTA a Leonora BUZANSKA

Vydání

Acta Neurobiologiae Experimentalis, Warsaw, Nencki Institute of Experimental Biology, 2014, 0065-1400

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.286

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00079057

Organizační jednotka

Lékařská fakulta

UT WoS

000348256100001

Klíčová slova anglicky

IPS cells; MRNA and miRNA transfection; Protein transduction; Somatic cells reprogramming

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 4. 2015 13:23, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Derivation of pluripotent stem cells from adult somatic tissues by reprogramming technology has opened new therapeutic possibilities. Current most efficient procedures for derivation of induced pluripotent stem (iPS) cells are based on the viral vectors, which represent the danger of insertional mutagenesis during incorporation of introduced genes into the host genome. To circumvent this problem, the new, safe, non-integrative and non-viral strategies of reprogramming have been developed. In this review we discuss novel DNA-free and viral-free methods of reprogramming to iPS cells including protein transduction, mRNA and microRNA delivery.

Návaznosti

MUNI/A/1014/2013, interní kód MU

Název: Zdroje pro tkáňové inženýrství 4

Investor: Masarykova univerzita, Zdroje pro tkáňové inženýrství 4, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

AUGUSTYNIAK, Justyna; Marzena ZYCHOWICZ; Martyna PODOBINSKA; Tomáš BÁRTA a Leonora BUZANSKA. Reprogramming of somatic cells: possible methods to derive safe, clinical-grade human induced pluripotent stem cells. Acta Neurobiologiae Experimentalis. Warsaw: Nencki Institute of Experimental Biology, 2014, roč. 74, č. 4, s. 373-382. ISSN 0065-1400.

@article{1225714,
   author = {Augustyniak, Justyna and Zychowicz, Marzena and Podobinska, Martyna and Bárta, Tomáš and Buzanska, Leonora},
   article_location = {Warsaw},
   article_number = {4},
   keywords = {IPS cells; MRNA and miRNA transfection; Protein transduction; Somatic cells reprogramming},
   language = {eng},
   issn = {0065-1400},
   journal = {Acta Neurobiologiae Experimentalis},
   title = {Reprogramming of somatic cells: possible methods to derive safe, clinical-grade human induced pluripotent stem cells},
   volume = {74},
   year = {2014}
}

TY  - JOUR
ID  - 1225714
AU  - Augustyniak, Justyna - Zychowicz, Marzena - Podobinska, Martyna - Bárta, Tomáš - Buzanska, Leonora
PY  - 2014
TI  - Reprogramming of somatic cells: possible methods to derive safe, clinical-grade human induced pluripotent stem cells
JF  - Acta Neurobiologiae Experimentalis
VL  - 74
IS  - 4
SP  - 373-382
EP  - 373-382
PB  - Nencki Institute of Experimental Biology
SN  - 00651400
KW  - IPS cells
KW  - MRNA and miRNA transfection
KW  - Protein transduction
KW  - Somatic cells reprogramming
N2  - Derivation of pluripotent stem cells from adult somatic tissues by reprogramming technology has opened new therapeutic possibilities. Current most efficient procedures for derivation of induced pluripotent stem (iPS) cells are based on the viral vectors, which represent the danger of insertional mutagenesis during incorporation of introduced genes into the host genome. To circumvent this problem, the new, safe, non-integrative and non-viral strategies of reprogramming have been developed. In this review we discuss novel DNA-free and viral-free methods of reprogramming to iPS cells including protein transduction, mRNA and microRNA delivery.
ER  -

AUGUSTYNIAK, Justyna; Marzena ZYCHOWICZ; Martyna PODOBINSKA; Tomáš BÁRTA a Leonora BUZANSKA. Reprogramming of somatic cells: possible methods to derive safe, clinical-grade human induced pluripotent stem cells. \textit{Acta Neurobiologiae Experimentalis}. Warsaw: Nencki Institute of Experimental Biology, 2014, roč.~74, č.~4, s.~373-382. ISSN~0065-1400.

Přehled o publikaci