Influence of smoking on disease severity and antimalarial
therapy in cutaneous lupus erythematosus: analysis of 1002
patients from the EUSCLE database

J 2014

Influence of smoking on disease severity and antimalarial therapy in cutaneous lupus erythematosus: analysis of 1002 patients from the EUSCLE database

KUHN, A.; J. SIGGES; C. BIAZAR; V. RULAND; N. PATSINAKIDIS et al.

Základní údaje

Originální název

Influence of smoking on disease severity and antimalarial therapy in cutaneous lupus erythematosus: analysis of 1002 patients from the EUSCLE database

Autoři

KUHN, A.; J. SIGGES; C. BIAZAR; V. RULAND; N. PATSINAKIDIS; A. LANDMANN; S. AMLER; G. BONSMANN; M. HAUST; F. NYBERG; Z. BATA; L. MIHÁLYI; R. OLTEANU; R.M. PUJOL; J.M. SÁNCHEZ-SCHMIDT; L. MEDENICA; D. SKILJEVIC; A. REICH; J.C. SZEPIETOWSKI; C. DALLE VEDOVE; G. GIROLOMONI; T. HAWRO; A. ZALEWSKA-JANOWSKA; R. GRAESER; R. HUEGEL; Hana JEDLIČKOVÁ; A. BYGUM; R. LAURINAVICIENE; S. BENOIT; E. BROECKER; F.A. BAHMER; E. ABERER; N. WUTTE; J. LIPOZENCIC; B. MARINOVIC; M. SÁRDY; V. BEKOU; T. RUZICKA; C. FRANCES; B. SOUTOU; H. LEE; M. WORM; A. GRUSCHKE; N. HUNZELMANN; K. STEINBRINK; R. ROMITI; M. STICHERLING; C. ERFURT-BERGE; G. AVGERINOU; D. PAPAFRAGKAKI; E. ANTIGA; M. CAPRONI; B. MAYER; B. VOLC-PLATZER; A. KREUTER; C. TIGGES; P.M. HEIL a G. STINGL

Vydání

British Journal of Dermatology, Hoboken, WILEY-BLACKWELL, 2014, 0007-0963

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30216 Dermatology and venereal diseases

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.275

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/14:00079720

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

CORE SET QUESTIONNAIRE; CIGARETTE-SMOKING; OUTCOME INSTRUMENT; QUINACRINE ATABRINE; ASSOCIATION; CLASI; TUMIDUS; INDEX; AREA; HYDROXYCHLOROQUINE

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 3. 2015 11:54, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Background In recent years it has been controversially discussed in the literature if smoking is associated with the activity of cutaneous lupus erythematosus (CLE) and the efficacy of antimalarial agents. Objectives To investigate the influence of smoking on disease severity and antimalarial treatment in patients with CLE using the Core Set Questionnaire of the European Society of Cutaneous Lupus Erythematosus (EUSCLE). Methods A total of 1002 patients (768 female, 234 male) with different CLE sub-types were included in this cross-sectional study, which was performed in 14 different countries. Smoking behaviour was assessed by the EUSCLE Core Set Questionnaire in 838 patients and statistically analysed using an SPSS database. The results were correlated with the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) and the efficacy of antimalarial treatment. Results A high percentage (87.2%) of the 499 patients with CLE, who have ever smoked, had already smoked at the date of their first diagnosis. Patients with intermittent CLE have ever smoked significantly more often than patients with subacute CLE (P < 0.05) and chronic CLE (P < 0.05). The total CLASI activity and damage score of patients with CLE was 6.6 +/- 7.1 and 2.6 +/- 4.3, respectively, and was higher in patients who have ever smoked than in nonsmokers. Antimalarial treatment was successful in 84.3% of cases, with a significantly higher efficacy in nonsmokers than in patients with CLE who have ever smoked (P < 0.05). Conclusions This analysis of a multicentre study population of 838 patients with CLE assessed by the EUSCLE Core Set Questionnaire confirms that smoking negatively influences CLE disease severity and the efficacy of antimalarial treatment.

Citovat

@article{1231637,
   author = {Kuhn, A. and Sigges, J. and Biazar, C. and Ruland, V. and Patsinakidis, N. and Landmann, A. and Amler, S. and Bonsmann, G. and Haust, M. and Nyberg, F. and Bata, Z. and Mihályi, L. and Olteanu, R. and Pujol, R.M. and SánchezandSchmidt, J.M. and Medenica, L. and Skiljevic, D. and Reich, A. and Szepietowski, J.C. and Dalle Vedove, C. and Girolomoni, G. and Hawro, T. and ZalewskaandJanowska, A. and Graeser, R. and Huegel, R. and Jedličková, Hana and Bygum, A. and Laurinaviciene, R. and Benoit, S. and Broecker, E. and Bahmer, F.A. and Aberer, E. and Wutte, N. and Lipozencic, J. and Marinovic, B. and Sárdy, M. and Bekou, V. and Ruzicka, T. and Frances, C. and Soutou, B. and Lee, H. and Worm, M. and Gruschke, A. and Hunzelmann, N. and Steinbrink, K. and Romiti, R. and Sticherling, M. and ErfurtandBerge, C. and Avgerinou, G. and Papafragkaki, D. and Antiga, E. and Caproni, M. and Mayer, B. and VolcandPlatzer, B. and Kreuter, A. and Tigges, C. and Heil, P.M. and Stingl, G.},
   article_location = {Hoboken},
   article_number = {3},
   doi = {https://doi.org/10.1111/bjd.13006},
   keywords = {CORE SET QUESTIONNAIRE; CIGARETTE-SMOKING; OUTCOME INSTRUMENT; QUINACRINE ATABRINE; ASSOCIATION; CLASI; TUMIDUS; INDEX; AREA; HYDROXYCHLOROQUINE},
   language = {eng},
   issn = {0007-0963},
   journal = {British Journal of Dermatology},
   note = {Ve WoS uvedena H. Jedličková jako jeden z "Group Author(s): EUSCLE Coauthors".},
   title = {Influence of smoking on disease severity and antimalarial therapy in cutaneous lupus erythematosus: analysis of 1002 patients from the EUSCLE database},
   volume = {171},
   year = {2014}
}

TY  - JOUR
ID  - 1231637
AU  - Kuhn, A. - Sigges, J. - Biazar, C. - Ruland, V. - Patsinakidis, N. - Landmann, A. - Amler, S. - Bonsmann, G. - Haust, M. - Nyberg, F. - Bata, Z. - Mihályi, L. - Olteanu, R. - Pujol, R.M. - Sánchez-Schmidt, J.M. - Medenica, L. - Skiljevic, D. - Reich, A. - Szepietowski, J.C. - Dalle Vedove, C. - Girolomoni, G. - Hawro, T. - Zalewska-Janowska, A. - Graeser, R. - Huegel, R. - Jedličková, Hana - Bygum, A. - Laurinaviciene, R. - Benoit, S. - Broecker, E. - Bahmer, F.A. - Aberer, E. - Wutte, N. - Lipozencic, J. - Marinovic, B. - Sárdy, M. - Bekou, V. - Ruzicka, T. - Frances, C. - Soutou, B. - Lee, H. - Worm, M. - Gruschke, A. - Hunzelmann, N. - Steinbrink, K. - Romiti, R. - Sticherling, M. - Erfurt-Berge, C. - Avgerinou, G. - Papafragkaki, D. - Antiga, E. - Caproni, M. - Mayer, B. - Volc-Platzer, B. - Kreuter, A. - Tigges, C. - Heil, P.M. - Stingl, G.
PY  - 2014
TI  - Influence of smoking on disease severity and antimalarial therapy in cutaneous lupus erythematosus: analysis of 1002 patients from the EUSCLE database
JF  - British Journal of Dermatology
VL  - 171
IS  - 3
SP  - 571-579
EP  - 571-579
PB  - WILEY-BLACKWELL
SN  - 00070963
N1  - Ve WoS uvedena H. Jedličková jako jeden z "Group Author(s): EUSCLE Coauthors".
KW  - CORE SET QUESTIONNAIRE
KW  - CIGARETTE-SMOKING
KW  - OUTCOME INSTRUMENT
KW  - QUINACRINE ATABRINE
KW  - ASSOCIATION
KW  - CLASI
KW  - TUMIDUS
KW  - INDEX
KW  - AREA
KW  - HYDROXYCHLOROQUINE
N2  - Background In recent years it has been controversially discussed in the literature if smoking is associated with the activity of cutaneous lupus erythematosus (CLE) and the efficacy of antimalarial agents. Objectives To investigate the influence of smoking on disease severity and antimalarial treatment in patients with CLE using the Core Set Questionnaire of the European Society of Cutaneous Lupus Erythematosus (EUSCLE). Methods A total of 1002 patients (768 female, 234 male) with different CLE sub-types were included in this cross-sectional study, which was performed in 14 different countries. Smoking behaviour was assessed by the EUSCLE Core Set Questionnaire in 838 patients and statistically analysed using an SPSS database. The results were correlated with the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) and the efficacy of antimalarial treatment. Results A high percentage (87.2%) of the 499 patients with CLE, who have ever smoked, had already smoked at the date of their first diagnosis. Patients with intermittent CLE have ever smoked significantly more often than patients with subacute CLE (P < 0.05) and chronic CLE (P < 0.05). The total CLASI activity and damage score of patients with CLE was 6.6 +/- 7.1 and 2.6 +/- 4.3, respectively, and was higher in patients who have ever smoked than in nonsmokers. Antimalarial treatment was successful in 84.3% of cases, with a significantly higher efficacy in nonsmokers than in patients with CLE who have ever smoked (P < 0.05). Conclusions This analysis of a multicentre study population of 838 patients with CLE assessed by the EUSCLE Core Set Questionnaire confirms that smoking negatively influences CLE disease severity and the efficacy of antimalarial treatment.
ER  -

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