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@article{1297363, author = {Aggarwal, Niti R. and Drozdová, Adéla and Askew III, Wells J. and Kemp, Bradley J. and Chareonthaitawee, Panithaya}, article_location = {New York}, article_number = {6}, doi = {http://dx.doi.org/10.1007/s12350-015-0073-z}, keywords = {Coronary artery disease; exercise stress testing; myocardial perfusion imaging; obesity; positron emission tomography}, language = {eng}, issn = {1071-3581}, journal = {Journal of Nuclear Cardiology}, title = {Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients}, volume = {22}, year = {2015} }
TY - JOUR ID - 1297363 AU - Aggarwal, Niti R. - Drozdová, Adéla - Askew III, Wells J. - Kemp, Bradley J. - Chareonthaitawee, Panithaya PY - 2015 TI - Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients JF - Journal of Nuclear Cardiology VL - 22 IS - 6 SP - 1273-1280 EP - 1273-1280 PB - Springer SN - 10713581 KW - Coronary artery disease KW - exercise stress testing KW - myocardial perfusion imaging KW - obesity KW - positron emission tomography N2 - Background. Treadmill exercise nitrogen-13 (13N)-ammonia positron emission tomography (PET) has logistical challenges and limited literature. We aimed to assess its feasibility, image quality, and diagnostic accuracy in obese and nonobese patients. Methods and Results. Between 2009 and 2012, 10,804 patients were referred for myocardial perfusion imaging, including 300 for treadmill PET, of whom 265 were included in this study. Treadmill testing and PET were performed using standard procedures. Image quality, perfusion, and summed stress score (SSS) were assessed. Invasive coronary angiography was performed within 90 days of PET in 43 patients. Mean ± SD body mass index (BMI) was 35.7 ± 7.7 kg/m2 (range 19.5-63.5 kg/m2). Feasibility of treadmill 13N-ammonia PET was 100%. Exercise duration was less for obese patients than nonobese patients (P < .001). Image quality was rated good for 96.9% of obese and 100% of nonobese patients. For all patients, sensitivity was 86.4% and specificity was 74.4%. Diagnostic accuracy did not change significantly with increasing BMI. SSS remained significant in predicting angiographic coronary artery disease after adjustment for age, sex, and Duke treadmill score. Conclusions. Treadmill 13N-ammonia PET is highly feasible, yields good image quality, and has moderately high diagnostic accuracy in a small subset of obese and nonobese patients who are deemed able to perform treadmill exercise. ER -
AGGARWAL, Niti R., Adéla DROZDOVÁ, Wells J. ASKEW III, Bradley J. KEMP a Panithaya CHAREONTHAITAWEE. Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients. \textit{Journal of Nuclear Cardiology}. New York: Springer, 2015, roč.~22, č.~6, s.~1273-1280. ISSN~1071-3581. Dostupné z: https://dx.doi.org/10.1007/s12350-015-0073-z.
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