Neurochemical and BOLD responses during neuronal activation
measured in the human visual cortex at 7 Tesla

J 2015

Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla

BEDNAŘÍK, Petr; Ivan TKAC; Federico GIOVE; Mauro DINUZZO; Dinesh K. DEELCHAND et al.

Základní údaje

Originální název

Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla

Autoři

BEDNAŘÍK, Petr; Ivan TKAC; Federico GIOVE; Mauro DINUZZO; Dinesh K. DEELCHAND; Uzay E. EMIR; Lynn E. EBERLY a Silvia MANGIA

Vydání

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, NEW YORK, NATURE PUBLISHING GROUP, 2015, 0271-678X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.929

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/15:00082816

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

Functional Spectroscopy; GABA quantification; Neurochemistry; Visual Stimulation

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 3. 2016 12:44, Mgr. Eva Špillingová

Anotace

V originále

Several laboratories have consistently reported small concentration changes in lactate, glutamate, aspartate, and glucose in the human cortex during prolonged stimuli. However, whether such changes correlate with blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI) signals have not been determined. The present study aimed at characterizing the relationship between metabolite concentrations and BOLD-fMRI signals during a block-designed paradigm of visual stimulation. Functional magnetic resonance spectroscopy (fMRS) and fMRI data were acquired from 12 volunteers. A short echo-time semiLASER localization sequence optimized for 7 Tesla was used to achieve full signal-intensity MRS data. The group analysis confirmed that during stimulation lactate and glutamate increased by 0.26 +/- 0.06 mu mol/g (similar to 30%) and 0.28 +/- 0.03 mu mol/g (similar to 3%), respectively, while aspartate and glucose decreased by 0.20 +/- 0.04 mu mol/g (similar to 5%) and 0.19 +/- 0.03 mu mol/g (similar to 16%), respectively. The single-subject analysis revealed that BOLD-fMRI signals were positively correlated with glutamate and lactate concentration changes. The results show a linear relationship between metabolic and BOLD responses in the presence of strong excitatory sensory inputs, and support the notion that increased functional energy demands are sustained by oxidative metabolism. In addition, BOLD signals were inversely correlated with baseline.-aminobutyric acid concentration. Finally, we discussed the critical importance of taking into account linewidth effects on metabolite quantification in fMRS paradigms.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

BEDNAŘÍK, Petr; Ivan TKAC; Federico GIOVE; Mauro DINUZZO; Dinesh K. DEELCHAND; Uzay E. EMIR; Lynn E. EBERLY a Silvia MANGIA. Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. NEW YORK: NATURE PUBLISHING GROUP, 2015, roč. 35, č. 4, s. 601-610. ISSN 0271-678X. Dostupné z: https://doi.org/10.1038/jcbfm.2014.233.

@article{1298992,
   author = {Bednařík, Petr and Tkac, Ivan and Giove, Federico and DiNuzzo, Mauro and Deelchand, Dinesh K. and Emir, Uzay E. and Eberly, Lynn E. and Mangia, Silvia},
   article_location = {NEW YORK},
   article_number = {4},
   doi = {https://doi.org/10.1038/jcbfm.2014.233},
   keywords = {Functional Spectroscopy; GABA quantification; Neurochemistry; Visual Stimulation},
   language = {eng},
   issn = {0271-678X},
   journal = {JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM},
   title = {Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla},
   url = {http://www.nature.com/jcbfm/journal/v35/n4/full/jcbfm2014233a.html},
   volume = {35},
   year = {2015}
}

TY  - JOUR
ID  - 1298992
AU  - Bednařík, Petr - Tkac, Ivan - Giove, Federico - DiNuzzo, Mauro - Deelchand, Dinesh K. - Emir, Uzay E. - Eberly, Lynn E. - Mangia, Silvia
PY  - 2015
TI  - Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla
JF  - JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
VL  - 35
IS  - 4
SP  - 601-610
EP  - 601-610
PB  - NATURE PUBLISHING GROUP
SN  - 0271678X
KW  - Functional Spectroscopy
KW  - GABA quantification
KW  - Neurochemistry
KW  - Visual Stimulation
UR  - http://www.nature.com/jcbfm/journal/v35/n4/full/jcbfm2014233a.html
L2  - http://www.nature.com/jcbfm/journal/v35/n4/full/jcbfm2014233a.html
N2  - Several laboratories have consistently reported small concentration changes in lactate, glutamate, aspartate, and glucose in the human cortex during prolonged stimuli. However, whether such changes correlate with blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI) signals have not been determined. The present study aimed at characterizing the relationship between metabolite concentrations and BOLD-fMRI signals during a block-designed paradigm of visual stimulation. Functional magnetic resonance spectroscopy (fMRS) and fMRI data were acquired from 12 volunteers. A short echo-time semiLASER localization sequence optimized for 7 Tesla was used to achieve full signal-intensity MRS data. The group analysis confirmed that during stimulation lactate and glutamate increased by 0.26 +/- 0.06 mu mol/g (similar to 30%) and 0.28 +/- 0.03 mu mol/g (similar to 3%), respectively, while aspartate and glucose decreased by 0.20 +/- 0.04 mu mol/g (similar to 5%) and 0.19 +/- 0.03 mu mol/g (similar to 16%), respectively. The single-subject analysis revealed that BOLD-fMRI signals were positively correlated with glutamate and lactate concentration changes. The results show a linear relationship between metabolic and BOLD responses in the presence of strong excitatory sensory inputs, and support the notion that increased functional energy demands are sustained by oxidative metabolism. In addition, BOLD signals were inversely correlated with baseline.-aminobutyric acid concentration. Finally, we discussed the critical importance of taking into account linewidth effects on metabolite quantification in fMRS paradigms.
ER  -

BEDNAŘÍK, Petr; Ivan TKAC; Federico GIOVE; Mauro DINUZZO; Dinesh K. DEELCHAND; Uzay E. EMIR; Lynn E. EBERLY a Silvia MANGIA. Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla. \textit{JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM}. NEW YORK: NATURE PUBLISHING GROUP, 2015, roč.~35, č.~4, s.~601-610. ISSN~0271-678X. Dostupné z: https://doi.org/10.1038/jcbfm.2014.233.

Přehled o publikaci