| STADLBAUER, Petr, Jiří ŠPONER, Giovanna COSTANZO, Ernesto DI MAURO, Samanta PINO a Judit ŠPONEROVÁ. Tetraloop-like Geometries Could Form the Basis of the Catalytic Activity of the Most Ancient Ribooligonucleotides. Chemistry - A European Journal. WEINHEIM: WILEY-VCH, 2015, roč. 21, č. 9, s. 3596-3604. ISSN 0947-6539. Dostupné z: https://dx.doi.org/10.1002/chem.201406140. |
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@article{1299594,
author = {Stadlbauer, Petr and Šponer, Jiří and Costanzo, Giovanna and Di Mauro, Ernesto and Pino, Samanta and Šponerová, Judit},
article_location = {WEINHEIM},
article_number = {9},
doi = {http://dx.doi.org/10.1002/chem.201406140},
keywords = {catalysis; molecular dynamics; oligonucleotides; ribozymes; RNA},
language = {eng},
issn = {0947-6539},
journal = {Chemistry - A European Journal},
title = {Tetraloop-like Geometries Could Form the Basis of the Catalytic Activity of the Most Ancient Ribooligonucleotides},
url = {http://onlinelibrary.wiley.com/doi/10.1002/chem.201406140/epdf},
volume = {21},
year = {2015}
}
TY - JOUR
ID - 1299594
AU - Stadlbauer, Petr - Šponer, Jiří - Costanzo, Giovanna - Di Mauro, Ernesto - Pino, Samanta - Šponerová, Judit
PY - 2015
TI - Tetraloop-like Geometries Could Form the Basis of the Catalytic Activity of the Most Ancient Ribooligonucleotides
JF - Chemistry - A European Journal
VL - 21
IS - 9
SP - 3596-3604
EP - 3596-3604
PB - WILEY-VCH
SN - 09476539
KW - catalysis
KW - molecular dynamics
KW - oligonucleotides
KW - ribozymes
KW - RNA
UR - http://onlinelibrary.wiley.com/doi/10.1002/chem.201406140/epdf
L2 - http://onlinelibrary.wiley.com/doi/10.1002/chem.201406140/epdf
N2 - The origin of the catalytic activity of ancient oligonucleotides is a largely unexplored field of contemporary science. In the current work we use molecular dynamics simulations to investigate the plausibility of tetraloop-like overhang geometries to initiate transphosphorylation reactions that lead to ligation and terminal cleavage in simple, Watson-Crick (WC) complementary oligoC/oligoG sequences observed experimentally. We show a series of examples of known tetraloop architectures, which can be adopted by the unpaired overhangs of short oligonucleotide sequences for a sufficiently long time to enable chemical reactions that lead to simple ribozyme-like catalytic activity. Thus, our computations demonstrate that the role of non-WC interactions at the emergence of the most ancient catalytic oligonucleotides could be more significant than ever believed.
ER -
STADLBAUER, Petr, Jiří ŠPONER, Giovanna COSTANZO, Ernesto DI MAURO, Samanta PINO a Judit ŠPONEROVÁ. Tetraloop-like Geometries Could Form the Basis of the Catalytic Activity of the Most Ancient Ribooligonucleotides. \textit{Chemistry - A European Journal}. WEINHEIM: WILEY-VCH, 2015, roč.~21, č.~9, s.~3596-3604. ISSN~0947-6539. Dostupné z: https://dx.doi.org/10.1002/chem.201406140.
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