Impact of risk factors on prevalence of anal HPV infection in
women with simultaneous cervical lesion

J 2015

Impact of risk factors on prevalence of anal HPV infection in women with simultaneous cervical lesion

SLAMA, J.; B. SEHNAL; Ladislav DUŠEK; T. ZIMA; D. CIBULA et al.

Základní údaje

Originální název

Impact of risk factors on prevalence of anal HPV infection in women with simultaneous cervical lesion

Autoři

SLAMA, J.; B. SEHNAL; Ladislav DUŠEK; T. ZIMA a D. CIBULA

Vydání

Neoplasma, Bratislava, Veda, 2015, 0028-2685

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.961

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/15:00082991

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.4149/neo_2015_037

UT WoS

000362862400017

EID Scopus

2-s2.0-84943617821

Klíčová slova anglicky

anal cancer; cervical intraepithelial neoplasia; HPV; risk factor

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 12. 2015 10:15, Soňa Böhmová

Anotace

V originále

The aim of our study was to determine the risk factors associated with anal HPV infection in HIV-negative women with high-grade cervical lesion. The study group included 172 “high-risk” women who underwent conization for high-grade cervical intraepithelial lesion or microinvasive cervical cancer (CIN 2+). The control group consisted of 100 “low-risk” women with non-neoplastic gynecologic diseases. All participants completed a questionnaire detailing medical history and sexual risk factors and were subjected to anal and cervical HPV genotyping. Concurrent cervical and anal HPV infections were detected in 42.4% (73/172) women of the study group, and in 8.0% (8/100) of women in the control group, respectively. The subgroup with concurrent HPV infections (n=73) dominated women with CIN 3 and microinvasive cancer and anal HPV 16 infections (n=53). Women with concurrent infections more frequently reported any type of sexual contact with the anus including non-penetrative anal sex (OR 2.62, p=0.008). Reporting >5 lifetime sexual partners (OR 2.43, p=0.041), smoking > 60 cigarettes per week (OR 2.33, p=0.048), and a history of penetrative anal intercourse (OR 3.87, p=0.002) were observed as the significant risk factors in women with multiple concurrent HPV infections. Our data support anal HPV testing and anal Pap smear screening in all women with severe cervical lesions caused by HPV 16 and a history of any sexual contact with the anus, heavy smoking and/or more than 5 lifetime sexual partners.

Citovat

SLAMA, J.; B. SEHNAL; Ladislav DUŠEK; T. ZIMA a D. CIBULA. Impact of risk factors on prevalence of anal HPV infection in women with simultaneous cervical lesion. Neoplasma. Bratislava: Veda, 2015, roč. 62, č. 2, s. 308-314. ISSN 0028-2685. Dostupné z: https://doi.org/10.4149/neo_2015_037.

@article{1300152,
   author = {Slama, J. and Sehnal, B. and Dušek, Ladislav and Zima, T. and Cibula, D.},
   article_location = {Bratislava},
   article_number = {2},
   doi = {https://doi.org/10.4149/neo_2015_037},
   keywords = {anal cancer; cervical intraepithelial neoplasia; HPV; risk factor},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {Impact of risk factors on prevalence of anal HPV infection in women with simultaneous cervical lesion},
   volume = {62},
   year = {2015}
}

TY  - JOUR
ID  - 1300152
AU  - Slama, J. - Sehnal, B. - Dušek, Ladislav - Zima, T. - Cibula, D.
PY  - 2015
TI  - Impact of risk factors on prevalence of anal HPV infection in women with simultaneous cervical lesion
JF  - Neoplasma
VL  - 62
IS  - 2
SP  - 308-314
EP  - 308-314
PB  - Veda
SN  - 00282685
KW  - anal cancer
KW  - cervical intraepithelial neoplasia
KW  - HPV
KW  - risk factor
N2  - The aim of our study was to determine the risk factors associated with anal HPV infection in HIV-negative women with high-grade cervical lesion. The study group included 172 “high-risk” women who underwent conization for high-grade cervical intraepithelial lesion or microinvasive cervical cancer (CIN 2+). The control group consisted of 100 “low-risk” women with non-neoplastic gynecologic diseases. All participants completed a questionnaire detailing medical history and sexual risk factors and were subjected to anal and cervical HPV genotyping. Concurrent cervical and anal HPV infections were detected in 42.4% (73/172) women of the study group, and in 8.0% (8/100) of women in the control group, respectively. The subgroup with concurrent HPV infections (n=73) dominated women with CIN 3 and microinvasive cancer and anal HPV 16 infections (n=53). Women with concurrent infections more frequently reported any type of sexual contact with the anus including non-penetrative anal sex (OR 2.62, p=0.008). Reporting >5 lifetime sexual partners (OR 2.43, p=0.041), smoking > 60 cigarettes per week (OR 2.33, p=0.048), and a history of penetrative anal intercourse (OR 3.87, p=0.002) were observed as the significant risk factors in women with multiple concurrent HPV infections. Our data support anal HPV testing and anal Pap smear screening in all women with severe cervical lesions caused by HPV 16 and a history of any sexual contact with the anus, heavy smoking and/or more than 5 lifetime sexual partners.
ER  -

SLAMA, J.; B. SEHNAL; Ladislav DUŠEK; T. ZIMA a D. CIBULA. Impact of risk factors on prevalence of anal HPV infection in women with simultaneous cervical lesion. \textit{Neoplasma}. Bratislava: Veda, 2015, roč.~62, č.~2, s.~308-314. ISSN~0028-2685. Dostupné z: https://doi.org/10.4149/neo\_{}2015\_{}037.

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