Enhanced survival of lethally irradiated adenosine A(3)
receptor knockout mice. A role for hematopoietic growth
factors?

J 2015

Enhanced survival of lethally irradiated adenosine A(3) receptor knockout mice. A role for hematopoietic growth factors?

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ; Denisa KOMŮRKOVÁ et al.

Základní údaje

Originální název

Enhanced survival of lethally irradiated adenosine A(3) receptor knockout mice. A role for hematopoietic growth factors?

Autoři

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ a Denisa KOMŮRKOVÁ

Vydání

Purinergic signalling, Dordrecht, Springer, 2015, 1573-9538

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.196

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/15:00082993

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Adenosine A(3) receptor; Postirradiation survival; Hematopoiesis; Granulocyte colony-stimulating factor; Erythropoietin; Thrombopoietin

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 5. 2015 15:15, Soňa Böhmová

Anotace

V originále

Adenosine A(3) receptor knockout (A(3)AR KO) mice and their wild-type (WT) counterparts were compared from the point of view of their abilities to survive exposures to lethal doses of gamma-radiation belonging to the range of radiation doses inducing the bone marrow acute radiation syndrome. Parameters of cumulative 30-day survival (experiment using a midlethal radiation dose) or cumulative 11-day survival (experiment using an absolutely lethal radiation dose), and of mean survival time were evaluated. The values of A(3)AR KO mice always reflected their higher survival in comparison with WT ones, the P values being above the limit for statistical significance after the midlethal radiation dose and standing for statistical significance after the absolutely lethal radiation dose. This finding was considered surprising, taking into account the previously obtained findings on defects in numbers and functional properties of peripheral blood cells in A(3)AR KO mice. Therefore, previous hematological analyses of A(3)AR KO mice were supplemented in the present studies with determination of serum levels of the granulocyte colony-stimulating factor, erythropoietin, and thrombopoietin. Though distinct differences in these parameters were observed between A(3)AR KO and WT mice, none of them could explain the relatively high postirradiation survival of A(3)AR KO mice. Further studies on these mice comprising also those on other than hemopoietic tissues and organs can help to clarify their relative radioresistance.

Citovat

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ a Denisa KOMŮRKOVÁ. Enhanced survival of lethally irradiated adenosine A(3) receptor knockout mice. A role for hematopoietic growth factors? Purinergic signalling. Dordrecht: Springer, 2015, roč. 11, č. 1, s. 79-85. ISSN 1573-9538. Dostupné z: https://doi.org/10.1007/s11302-014-9432-5.

@article{1300158,
   author = {Hofer, Michal and Pospíšil, Milan and Dušek, Ladislav and Hoferová, Zuzana and Komůrková, Denisa},
   article_location = {Dordrecht},
   article_number = {1},
   doi = {https://doi.org/10.1007/s11302-014-9432-5},
   keywords = {Adenosine A(3) receptor; Postirradiation survival; Hematopoiesis; Granulocyte colony-stimulating factor; Erythropoietin; Thrombopoietin},
   language = {eng},
   issn = {1573-9538},
   journal = {Purinergic signalling},
   title = {Enhanced survival of lethally irradiated adenosine A(3) receptor knockout mice. A role for hematopoietic growth factors?},
   volume = {11},
   year = {2015}
}

TY  - JOUR
ID  - 1300158
AU  - Hofer, Michal - Pospíšil, Milan - Dušek, Ladislav - Hoferová, Zuzana - Komůrková, Denisa
PY  - 2015
TI  - Enhanced survival of lethally irradiated adenosine A(3) receptor knockout mice. A role for hematopoietic growth factors?
JF  - Purinergic signalling
VL  - 11
IS  - 1
SP  - 79-85
EP  - 79-85
PB  - Springer
SN  - 15739538
KW  - Adenosine A(3) receptor
KW  - Postirradiation survival
KW  - Hematopoiesis
KW  - Granulocyte colony-stimulating factor
KW  - Erythropoietin
KW  - Thrombopoietin
N2  - Adenosine A(3) receptor knockout (A(3)AR KO) mice and their wild-type (WT) counterparts were compared from the point of view of their abilities to survive exposures to lethal doses of gamma-radiation belonging to the range of radiation doses inducing the bone marrow acute radiation syndrome. Parameters of cumulative 30-day survival (experiment using a midlethal radiation dose) or cumulative 11-day survival (experiment using an absolutely lethal radiation dose), and of mean survival time were evaluated. The values of A(3)AR KO mice always reflected their higher survival in comparison with WT ones, the P values being above the limit for statistical significance after the midlethal radiation dose and standing for statistical significance after the absolutely lethal radiation dose. This finding was considered surprising, taking into account the previously obtained findings on defects in numbers and functional properties of peripheral blood cells in A(3)AR KO mice. Therefore, previous hematological analyses of A(3)AR KO mice were supplemented in the present studies with determination of serum levels of the granulocyte colony-stimulating factor, erythropoietin, and thrombopoietin. Though distinct differences in these parameters were observed between A(3)AR KO and WT mice, none of them could explain the relatively high postirradiation survival of A(3)AR KO mice. Further studies on these mice comprising also those on other than hemopoietic tissues and organs can help to clarify their relative radioresistance.
ER  -

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ a Denisa KOMŮRKOVÁ. Enhanced survival of lethally irradiated adenosine A(3) receptor knockout mice. A role for hematopoietic growth factors? \textit{Purinergic signalling}. Dordrecht: Springer, 2015, roč.~11, č.~1, s.~79-85. ISSN~1573-9538. Dostupné z: https://doi.org/10.1007/s11302-014-9432-5.

Přehled o publikaci