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@proceedings{1306212, author = {Pekarčíková, Lucie and Knopfová, Lucia and Šmarda, Jan}, booktitle = {6th recamo joint meeting}, keywords = {c-myb, colorectal carcinoma, oxidative stress}, language = {eng}, isbn = {978-80-86793-37-5}, title = {The role of c-Myb in oxidative stress}, year = {2015} }
TY - CONF ID - 1306212 AU - Pekarčíková, Lucie - Knopfová, Lucia - Šmarda, Jan PY - 2015 TI - The role of c-Myb in oxidative stress SN - 9788086793375 KW - c-myb, colorectal carcinoma, oxidative stress N2 - Colorectal carcinoma is the third most common cancer worldwide and is one of the leading causes of cancer-related deaths. c-Myb is a transcription factor playing essential role in control of proliferation, differentiation and apoptosis. c-Myb overexpression in colorectal cancer is known to be a prognostic indicator for poor prognosis of patients. In this work, we showed that c-Myb is significantly involved in pro-survival signalling pathways and we described a novel signal axis mediating decreased sensitivity of CRC cells to cytotoxic agents and documented for the first time that the prosurvival role of c-Myb is associated with deregulation of reactive oxygen species. ER -
PEKARČÍKOVÁ, Lucie, Lucia KNOPFOVÁ a Jan ŠMARDA. The role of c-Myb in oxidative stress. In \textit{6th recamo joint meeting}. 2015. ISBN~978-80-86793-37-5.
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