Biological Activity and Molecular Structures of
Bis(benzimidazole) and Trithiocyanurate Complexes

J 2015

Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes

KOPEL, Pavel; Dorota WAWRZAK; Vratislav LANGER; Kristyna CIHALOVA; Dagmar CHUDOBOVA et al.

Základní údaje

Originální název

Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes

Autoři

KOPEL, Pavel; Dorota WAWRZAK; Vratislav LANGER; Kristyna CIHALOVA; Dagmar CHUDOBOVA; Radek VESELÝ; Vojtech ADAM a Rene KIZEK

Vydání

Molecules, Basel, MDPI AG, 2015, 1420-3049

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30211 Orthopaedics

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.465

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/15:00083400

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

coordination compounds; biological activity; trithiocyanuric acid; trimercaptotriazine; single crystal X-ray diffraction; benzimidazole

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 2. 2016 10:42, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

1-(1H-Benzimidazol-2-yl)-N-(1H-benzimidazol-2-ylmethyl)methanamine (abb) and 2-(1H-benzimidazol-2-ylmethylsulfanylmethyl)-1H-benzimidazole (tbb) have been prepared and characterized by elemental analysis. These bis(benzimidazoles) have been further used in combination with trithiocyanuric acid for the preparation of complexes. The crystal and molecular structures of two of them have been solved. Each nickel atom in the structure of trinuclear complex [Ni3(abb)3(H2O)3ttc)](ClO4)3·3H2O·EtOH (1), where ttcH3 = trithiocyanuric acid, is coordinated with three N atoms of abb, the N,S donor set of ttc anion and an oxygen of a water molecule. The crystal of [(tbbH2)(ttcH2)2(ttcH3)(H2O)] (2) is composed of a protonated bis(benzimidazole), two ttcH2 anions, ttcH3 and water. The structure is stabilized by a network of hydrogen bonds. These compounds were primarily synthesized for their potential antimicrobial activity and hence their possible use in the treatment of infections caused by bacteria or yeasts (fungi). The antimicrobial and antifungal activity of the prepared compounds have been evaluated on a wide spectrum of bacterial and yeast strains and clinical specimens isolated from patients with infectious wounds and the best antimicrobial properties were observed in strains after the use of ligand abb and complex 1, when at least 80% growth inhibition was achieved.

Citovat

KOPEL, Pavel; Dorota WAWRZAK; Vratislav LANGER; Kristyna CIHALOVA; Dagmar CHUDOBOVA; Radek VESELÝ; Vojtech ADAM a Rene KIZEK. Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes. Molecules. Basel: MDPI AG, 2015, roč. 20, č. 6, s. 10360-10376. ISSN 1420-3049. Dostupné z: https://doi.org/10.3390/molecules200610360.

@article{1306321,
   author = {Kopel, Pavel and Wawrzak, Dorota and Langer, Vratislav and Cihalova, Kristyna and Chudobova, Dagmar and Veselý, Radek and Adam, Vojtech and Kizek, Rene},
   article_location = {Basel},
   article_number = {6},
   doi = {https://doi.org/10.3390/molecules200610360},
   keywords = {coordination compounds; biological activity; trithiocyanuric acid; trimercaptotriazine; single crystal X-ray diffraction; benzimidazole},
   language = {eng},
   issn = {1420-3049},
   journal = {Molecules},
   title = {Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes},
   volume = {20},
   year = {2015}
}

TY  - JOUR
ID  - 1306321
AU  - Kopel, Pavel - Wawrzak, Dorota - Langer, Vratislav - Cihalova, Kristyna - Chudobova, Dagmar - Veselý, Radek - Adam, Vojtech - Kizek, Rene
PY  - 2015
TI  - Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes
JF  - Molecules
VL  - 20
IS  - 6
SP  - 10360-10376
EP  - 10360-10376
PB  - MDPI AG
SN  - 14203049
KW  - coordination compounds
KW  - biological activity
KW  - trithiocyanuric acid
KW  - trimercaptotriazine
KW  - single crystal X-ray diffraction
KW  - benzimidazole
N2  - 1-(1H-Benzimidazol-2-yl)-N-(1H-benzimidazol-2-ylmethyl)methanamine (abb) and 2-(1H-benzimidazol-2-ylmethylsulfanylmethyl)-1H-benzimidazole (tbb) have been prepared and characterized by elemental analysis. These bis(benzimidazoles) have been further used in combination with trithiocyanuric acid for the preparation of complexes. The crystal and molecular structures of two of them have been solved. Each nickel atom in the structure of trinuclear complex [Ni3(abb)3(H2O)3ttc)](ClO4)3·3H2O·EtOH (1), where ttcH3 = trithiocyanuric acid, is coordinated with three N atoms of abb, the N,S donor set of ttc anion and an oxygen of a water molecule. The crystal of [(tbbH2)(ttcH2)2(ttcH3)(H2O)] (2) is composed of a protonated bis(benzimidazole), two ttcH2 anions, ttcH3 and water. The structure is stabilized by a network of hydrogen bonds. These compounds were primarily synthesized for their potential antimicrobial activity and hence their possible use in the treatment of infections caused by bacteria or yeasts (fungi). The antimicrobial and antifungal activity of the prepared compounds have been evaluated on a wide spectrum of bacterial and yeast strains and clinical specimens isolated from patients with infectious wounds and the best antimicrobial properties were observed in strains after the use of ligand abb and complex 1, when at least 80% growth inhibition was achieved.
ER  -

KOPEL, Pavel; Dorota WAWRZAK; Vratislav LANGER; Kristyna CIHALOVA; Dagmar CHUDOBOVA; Radek VESELÝ; Vojtech ADAM a Rene KIZEK. Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes. \textit{Molecules}. Basel: MDPI AG, 2015, roč.~20, č.~6, s.~10360-10376. ISSN~1420-3049. Dostupné z: https://doi.org/10.3390/molecules200610360.

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