| TKADLEC, Jan, Eva VAŘEKOVÁ, Roman PANTŮČEK, Jiří DOŠKAŘ, Vladislava RŮŽIČKOVÁ, Tibor BOTKA, Libor FILA a Oto MELTER. Characterization of Staphylococcus aureus strains isolated from Czech cystic fibrosis patients: high rate of ribosomal mutation conferring resistance to MLSB antibiotics as a result of long-term and low-dose azithromycin treatment. Microbial Drug Resistance. New Rochelle, NY, USA: Mary Ann Liebert Inc., 2015, roč. 21, č. 4, s. 416-423. ISSN 1076-6294. Dostupné z: https://dx.doi.org/10.1089/mdr.2014.0276. |
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@article{1307078,
author = {Tkadlec, Jan and Vařeková, Eva and Pantůček, Roman and Doškař, Jiří and Růžičková, Vladislava and Botka, Tibor and Fila, Libor and Melter, Oto},
article_location = {New Rochelle, NY, USA},
article_number = {4},
doi = {http://dx.doi.org/10.1089/mdr.2014.0276},
keywords = {Staphylococcus aureus; cystic fibrosis; small colony variants; MLSB resistance;},
language = {eng},
issn = {1076-6294},
journal = {Microbial Drug Resistance},
title = {Characterization of Staphylococcus aureus strains isolated from Czech cystic fibrosis patients: high rate of ribosomal mutation conferring resistance to MLSB antibiotics as a result of long-term and low-dose azithromycin treatment},
url = {http://online.liebertpub.com/doi/10.1089/mdr.2014.0276},
volume = {21},
year = {2015}
}
TY - JOUR
ID - 1307078
AU - Tkadlec, Jan - Vařeková, Eva - Pantůček, Roman - Doškař, Jiří - Růžičková, Vladislava - Botka, Tibor - Fila, Libor - Melter, Oto
PY - 2015
TI - Characterization of Staphylococcus aureus strains isolated from Czech cystic fibrosis patients: high rate of ribosomal mutation conferring resistance to MLSB antibiotics as a result of long-term and low-dose azithromycin treatment
JF - Microbial Drug Resistance
VL - 21
IS - 4
SP - 416-423
EP - 416-423
PB - Mary Ann Liebert Inc.
SN - 10766294
KW - Staphylococcus aureus
KW - cystic fibrosis
KW - small colony variants
KW - MLSB resistance;
UR - http://online.liebertpub.com/doi/10.1089/mdr.2014.0276
L2 - http://online.liebertpub.com/doi/10.1089/mdr.2014.0276
N2 - Staphylococcus aureus is one of the most frequent pathogens infecting the respiratory tract of patients with cystic fibrosis (CF). This study was the first to examine S. aureus isolates from CF patients in the Czech Republic. Among 100 S. aureus isolates from 92 of 107 observed patients, we found a high prevalence of resistance to macrolide–lincosamide–streptogramin B (MLSB) antibiotics (56%). More than half of the resistant strains (29 of 56) carried a mutation in the MLSB target site. The emergence of MLSB resistance and mutations conferring resistance to MLSB antibiotics was associated with azithromycin treatment (p=0.000000184 and p=0.000681, respectively). Methicillin resistance was only detected in 3% of isolates and the rate of resistance to other antibiotics did not exceed 12%. The prevalence of small-colony variant (SCV) strains was relatively low (9%) and eight of nine isolates with the SCV phenotype were thymidine dependent. The study population of S. aureus was heterogeneous in structure and both the most prevalent community-associated and hospital-acquired clonal lineages were represented. Of the virulence genes, enterotoxin genes seg (n=52), sei (n=49), and sec (n=16) were the most frequently detected among the isolates. The PVL genes (lukS-PV and lukF-PV) have not been revealed in any of the isolates.
ER -
TKADLEC, Jan, Eva VAŘEKOVÁ, Roman PANTŮČEK, Jiří DOŠKAŘ, Vladislava RŮŽIČKOVÁ, Tibor BOTKA, Libor FILA a Oto MELTER. Characterization of Staphylococcus aureus strains isolated from Czech cystic fibrosis patients: high rate of ribosomal mutation conferring resistance to MLSB antibiotics as a result of long-term and low-dose azithromycin treatment. \textit{Microbial Drug Resistance}. New Rochelle, NY, USA: Mary Ann Liebert Inc., 2015, roč.~21, č.~4, s.~416-423. ISSN~1076-6294. Dostupné z: https://dx.doi.org/10.1089/mdr.2014.0276.
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