HOFER, M., M. POSPÍŠIL, Ladislav DUŠEK, Z. HOFEROVÁ a D. KOMŮRKOVÁ. Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice. Physiological Research. Praha: Institute of Physiology, Academy of Sciences of the Czech Republic, roč. 64, č. 2, s. 255-262. ISSN 0862-8408. 2015.
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Základní údaje
Originální název Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice
Autoři HOFER, M. (203 Česká republika), M. POSPÍŠIL (203 Česká republika), Ladislav DUŠEK (203 Česká republika, domácí), Z. HOFEROVÁ (203 Česká republika) a D. KOMŮRKOVÁ (203 Česká republika, garant).
Vydání Physiological Research, Praha, Institute of Physiology, Academy of Sciences of the Czech Republic, 2015, 0862-8408.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30105 Physiology
Stát vydavatele Česká republika
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 1.643
Kód RIV RIV/00216224:14110/15:00083581
Organizační jednotka Lékařská fakulta
UT WoS 000357409400013
Klíčová slova anglicky Adenosine A(3) receptor knock-out mice; Hematopoiesis; 5-fluorouracil-induced hematotoxicity
Štítky EL OK
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Soňa Böhmová, učo 232884. Změněno: 19. 8. 2015 14:43.
Anotace
The purpose of the study was to describe and compare normal and 5-fluorouracil (5-FU)-suppressed hematopoiesis in adenosine A(3) receptor knock-out (A(3)AR KO) mice and their wild-type (WT) counterparts. To meet the purpose, a complex hematological analysis comprising nineteen peripheral blood and bone marrow parameters was performed in the mice. Defects previously observed in the peripheral blood erythrocyte and thrombocyte parameters of the A3AR KO mice were confirmed. Compartments of the bone marrow progenitor cells for granulocytes/macrophages and erythrocytes were enhanced in the control, as well as in the 5-FU-administered A3AR KO mice. 5-FU-induced hematopoietic suppression, evaluated on day 2 after the administration of the cytotoxic drug, was found to be significantly deeper in the A3AR KO mice compared with their WT counterparts, as measured at the level of the bone marrow progenitor cells. The rate of regeneration, as assessed between days 2 and 7 after 5-FU administration, was observed in the population of the granulocyte/macrophage progenitor cells to be higher in the A3AR KO mice in comparison with the WT ones. The increased depth of 5-FU-induced suppression in the compartments of the hematopoietic progenitor cells in the A3AR KO mice represents probably a hitherto undescribed further consequence of the lack of adenosine A3 receptors and indicates its synergism with the pharmacologically induced cytotoxic action of 5-FU.
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