HOFER, M., M. POSPÍŠIL, Ladislav DUŠEK, Z. HOFEROVÁ a D. KOMŮRKOVÁ. Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice. Physiological Research. Praha: Institute of Physiology, Academy of Sciences of the Czech Republic, 2015, roč. 64, č. 2, s. 255-262. ISSN 0862-8408. |
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@article{1308715, author = {Hofer, M. and Pospíšil, M. and Dušek, Ladislav and Hoferová, Z. and Komůrková, D.}, article_location = {Praha}, article_number = {2}, keywords = {Adenosine A(3) receptor knock-out mice; Hematopoiesis; 5-fluorouracil-induced hematotoxicity}, language = {eng}, issn = {0862-8408}, journal = {Physiological Research}, title = {Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice}, volume = {64}, year = {2015} }
TY - JOUR ID - 1308715 AU - Hofer, M. - Pospíšil, M. - Dušek, Ladislav - Hoferová, Z. - Komůrková, D. PY - 2015 TI - Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice JF - Physiological Research VL - 64 IS - 2 SP - 255-262 EP - 255-262 PB - Institute of Physiology, Academy of Sciences of the Czech Republic SN - 08628408 KW - Adenosine A(3) receptor knock-out mice KW - Hematopoiesis KW - 5-fluorouracil-induced hematotoxicity N2 - The purpose of the study was to describe and compare normal and 5-fluorouracil (5-FU)-suppressed hematopoiesis in adenosine A(3) receptor knock-out (A(3)AR KO) mice and their wild-type (WT) counterparts. To meet the purpose, a complex hematological analysis comprising nineteen peripheral blood and bone marrow parameters was performed in the mice. Defects previously observed in the peripheral blood erythrocyte and thrombocyte parameters of the A3AR KO mice were confirmed. Compartments of the bone marrow progenitor cells for granulocytes/macrophages and erythrocytes were enhanced in the control, as well as in the 5-FU-administered A3AR KO mice. 5-FU-induced hematopoietic suppression, evaluated on day 2 after the administration of the cytotoxic drug, was found to be significantly deeper in the A3AR KO mice compared with their WT counterparts, as measured at the level of the bone marrow progenitor cells. The rate of regeneration, as assessed between days 2 and 7 after 5-FU administration, was observed in the population of the granulocyte/macrophage progenitor cells to be higher in the A3AR KO mice in comparison with the WT ones. The increased depth of 5-FU-induced suppression in the compartments of the hematopoietic progenitor cells in the A3AR KO mice represents probably a hitherto undescribed further consequence of the lack of adenosine A3 receptors and indicates its synergism with the pharmacologically induced cytotoxic action of 5-FU. ER -
HOFER, M., M. POSPÍŠIL, Ladislav DUŠEK, Z. HOFEROVÁ a D. KOMŮRKOVÁ. Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice. \textit{Physiological Research}. Praha: Institute of Physiology, Academy of Sciences of the Czech Republic, 2015, roč.~64, č.~2, s.~255-262. ISSN~0862-8408.
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