Prognostic Value of Pentraxin-3 Level in Patients with STEMI
and Its Relationship with Heart Failure and Markers of
Oxidative Stress

J 2015

Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress

TOMANDLOVÁ, Marie; Jiří JARKOVSKÝ; Josef TOMANDL; Lenka KUBKOVA; Petr KALA et. al.

Základní údaje

Originální název

Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress

Autoři

TOMANDLOVÁ, Marie (203 Česká republika, garant, domácí); Jiří JARKOVSKÝ (203 Česká republika, domácí); Josef TOMANDL (203 Česká republika, domácí); Lenka KUBKOVA (203 Česká republika); Petr KALA (203 Česká republika, domácí); Simona LITTNEROVÁ (203 Česká republika, domácí); Jana GOTTWALDOVÁ (203 Česká republika, domácí); Petr KUBENA (203 Česká republika, domácí); Eva GANOVSKÁ (703 Slovensko, domácí); Martin POLOCZEK (203 Česká republika); Jindřich ŠPINAR (203 Česká republika, domácí); Christian MUELLER (756 Švýcarsko); Alexandre MEBAZAA (250 Francie); Monika PÁVKOVÁ GOLDBERGOVÁ (203 Česká republika, domácí) a Jiří PAŘENICA (203 Česká republika, domácí)

Vydání

Disease Markers, New York, Hindawi Publishing Corporation, 2015, 0278-0240

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.137

Kód RIV

RIV/00216224:14110/15:00083744

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1155/2015/159051

UT WoS

000353506800001

EID Scopus

2-s2.0-84928244007

Klíčová slova anglicky

ACUTE MYOCARDIAL-INFARCTION; C-REACTIVE PROTEIN; ACUTE CORONARY SYNDROME; PERFORMANCE LIQUID-CHROMATOGRAPHY; LONG PENTRAXIN; ANTIOXIDANT ACTIVITY; RISK-ASSESSMENT; TNF-ALPHA; ELEVATION; PTX3

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 12. 2015 14:36, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Objective. Pentraxin-3 (PTX3) appears to have a cardioprotective effect through a positive influence against postreperfusion damage. This study assesses the prognostic value of PTX3 level and its relationship with clinical parameters and markers of oxidative stress and nitric oxide metabolism in patients with ST-elevation myocardial infarction (STEMI). Methods. Plasma/serum levels of several biomarkers of inflammation and oxidative stress and nitrite/nitrate were assessed upon admission and 24 h after STEMI onset in patients treated by primary percutaneous coronary intervention. Results. ROC analysis showed that plasma PTX3 at 24 h was a strong predictor of 30-day and 1-year mortality and independent predictor of combined end-point of left ventricle dysfunction or mortality in 1 year. The inflammatory response expressed by PTX3 had a significant relationship with age, heart failure, infarct size, impaired flow in the infarct-related artery, and renal function and positively correlated with neopterin, TNF-alpha, 8-hydroxy-2'-deoxyguanosine, and nitrite/nitrate. Conclusions. Plasma PTX3 at 24 h after STEMI onset is a strong predictor of 30-day and 1-year mortality. PTX3 as a single biomarker is comparable with currently used scoring systems (TIMI or GRACE) or B-type natriuretic peptide. PTX3 is also an independent predictor of combined end-point of left ventricle dysfunction or mortality in 1 year.

Návaznosti

MUNI/A/0954/2013, interní kód MU

Název: Příspěvek chemických a biochemických metodik ke studiu molekulární podstaty vybraných patologických stavů a onemocnění (Akronym: BIOMET3)

Investor: Masarykova univerzita, Příspěvek chemických a biochemických metodik ke studiu molekulární podstaty vybraných patologických stavů a onemocnění, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

MUNI/A/1012/2013, interní kód MU

Název: Diagnostika akutní myokarditidy mimikující akutní infarkt myokardu s ST elevacemi

Investor: Masarykova univerzita, Diagnostika akutní myokarditidy mimikující akutní infarkt myokardu s ST elevacemi, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

TOMANDLOVÁ, Marie; Jiří JARKOVSKÝ; Josef TOMANDL; Lenka KUBKOVA; Petr KALA; Simona LITTNEROVÁ; Jana GOTTWALDOVÁ; Petr KUBENA; Eva GANOVSKÁ; Martin POLOCZEK; Jindřich ŠPINAR; Christian MUELLER; Alexandre MEBAZAA; Monika PÁVKOVÁ GOLDBERGOVÁ a Jiří PAŘENICA. Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress. Disease Markers. New York: Hindawi Publishing Corporation, 2015, roč. 2015, č. 159051, s. 1-11. ISSN 0278-0240. Dostupné z: https://dx.doi.org/10.1155/2015/159051.

@article{1310363,
   author = {Tomandlová, Marie and Jarkovský, Jiří and Tomandl, Josef and Kubkova, Lenka and Kala, Petr and Littnerová, Simona and Gottwaldová, Jana and Kubena, Petr and Ganovská, Eva and Poloczek, Martin and Špinar, Jindřich and Mueller, Christian and Mebazaa, Alexandre and Pávková Goldbergová, Monika and Pařenica, Jiří},
   article_location = {New York},
   article_number = {159051},
   doi = {http://dx.doi.org/10.1155/2015/159051},
   keywords = {ACUTE MYOCARDIAL-INFARCTION; C-REACTIVE PROTEIN; ACUTE CORONARY SYNDROME; PERFORMANCE LIQUID-CHROMATOGRAPHY; LONG PENTRAXIN; ANTIOXIDANT ACTIVITY; RISK-ASSESSMENT; TNF-ALPHA; ELEVATION; PTX3},
   language = {eng},
   issn = {0278-0240},
   journal = {Disease Markers},
   title = {Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress},
   volume = {2015},
   year = {2015}
}

TY  - JOUR
ID  - 1310363
AU  - Tomandlová, Marie - Jarkovský, Jiří - Tomandl, Josef - Kubkova, Lenka - Kala, Petr - Littnerová, Simona - Gottwaldová, Jana - Kubena, Petr - Ganovská, Eva - Poloczek, Martin - Špinar, Jindřich - Mueller, Christian - Mebazaa, Alexandre - Pávková Goldbergová, Monika - Pařenica, Jiří
PY  - 2015
TI  - Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress
JF  - Disease Markers
VL  - 2015
IS  - 159051
SP  - 1-11
EP  - 1-11
PB  - Hindawi Publishing Corporation
SN  - 02780240
KW  - ACUTE MYOCARDIAL-INFARCTION
KW  - C-REACTIVE PROTEIN
KW  - ACUTE CORONARY SYNDROME
KW  - PERFORMANCE LIQUID-CHROMATOGRAPHY
KW  - LONG PENTRAXIN
KW  - ANTIOXIDANT ACTIVITY
KW  - RISK-ASSESSMENT
KW  - TNF-ALPHA
KW  - ELEVATION
KW  - PTX3
N2  - Objective. Pentraxin-3 (PTX3) appears to have a cardioprotective effect through a positive influence against postreperfusion damage. This study assesses the prognostic value of PTX3 level and its relationship with clinical parameters and markers of oxidative stress and nitric oxide metabolism in patients with ST-elevation myocardial infarction (STEMI). Methods. Plasma/serum levels of several biomarkers of inflammation and oxidative stress and nitrite/nitrate were assessed upon admission and 24 h after STEMI onset in patients treated by primary percutaneous coronary intervention. Results. ROC analysis showed that plasma PTX3 at 24 h was a strong predictor of 30-day and 1-year mortality and independent predictor of combined end-point of left ventricle dysfunction or mortality in 1 year. The inflammatory response expressed by PTX3 had a significant relationship with age, heart failure, infarct size, impaired flow in the infarct-related artery, and renal function and positively correlated with neopterin, TNF-alpha, 8-hydroxy-2'-deoxyguanosine, and nitrite/nitrate. Conclusions. Plasma PTX3 at 24 h after STEMI onset is a strong predictor of 30-day and 1-year mortality. PTX3 as a single biomarker is comparable with currently used scoring systems (TIMI or GRACE) or B-type natriuretic peptide. PTX3 is also an independent predictor of combined end-point of left ventricle dysfunction or mortality in 1 year.
ER  -

TOMANDLOVÁ, Marie; Jiří JARKOVSKÝ; Josef TOMANDL; Lenka KUBKOVA; Petr KALA; Simona LITTNEROVÁ; Jana GOTTWALDOVÁ; Petr KUBENA; Eva GANOVSKÁ; Martin POLOCZEK; Jindřich ŠPINAR; Christian MUELLER; Alexandre MEBAZAA; Monika PÁVKOVÁ GOLDBERGOVÁ a Jiří PAŘENICA. Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress. \textit{Disease Markers}. New York: Hindawi Publishing Corporation, 2015, roč.~2015, č.~159051, s.~1-11. ISSN~0278-0240. Dostupné z: https://dx.doi.org/10.1155/2015/159051.

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