KRALICKOVA, Pavlina, Barbora KURECOVA, Ctirad ANDRYS, Irena KRCMOVA, Dalibor JILEK, Marcela VLKOVÁ a Jiří LITZMAN. Pregnancy Outcome in Patients with Common Variable Immunodeficiency. Journal of Clinical Immunology. New York: Springer New York, 2015, roč. 35, č. 6, s. 531-537. ISSN 0271-9142. doi:10.1007/s10875-015-0188-7.
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Základní údaje
Originální název Pregnancy Outcome in Patients with Common Variable Immunodeficiency
Autoři KRALICKOVA, Pavlina (203 Česká republika), Barbora KURECOVA (203 Česká republika), Ctirad ANDRYS (203 Česká republika), Irena KRCMOVA (203 Česká republika), Dalibor JILEK (203 Česká republika), Marcela VLKOVÁ (203 Česká republika, domácí) a Jiří LITZMAN (203 Česká republika, garant, domácí).
Vydání Journal of Clinical Immunology, New York, Springer New York, 2015, 0271-9142.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30300 3.3 Health sciences
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 3.094
Kód RIV RIV/00216224:14110/15:00083995
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1007/s10875-015-0188-7
UT WoS 000361524700005
Klíčová slova anglicky CVID; fertility; pregnancy; replacement therapy
Štítky EL OK
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Ing. Mgr. Věra Pospíšilíková, učo 9005. Změněno: 3. 11. 2015 15:03.
Anotace
Purpose: The aim of our retrospective study was to clarify fertility, pregnancy complications and outcomes in common variable immunodeficiency (CVID) females. Methods: Retrospective data were obtained from three Czech referral centres. The data were compared with data obtained from the Czech National Registry of Reproduction Health. Results: Our cohort of patients comprised 54 women with 115 pregnancies; 88 pregnancies in 50 females were finished with live births (77 %). In only 8 women (15 %) was the diagnosis of CVID established before the first pregnancy. Replacement immunoglobulin therapy was performed in 10 patients without any moderate or severe adverse effects. Compared with the Czech population, the CVID patients suffered significantly more frequently from the threat of preterm labour (p < 0.0001), vaginal bleeding (p = 0.0001), eclampsia/preeclampsia (p = 0.009) and a higher number of stillbirths (p < 0.0001). Furthermore, the frequency of babies with low birth weight (less than 2500 g) born to the CVID patients was increased compared with the normal population (p < 0.0001). Serum IgG, IgA and IgM determination was done in 57 children of 50 mothers showing 13 cases of IgA deficiency (23 %). There was no significant difference among the non-symptomatic, symptomatic untreated and symptomatic treated females in any of the determined gynaecological complications. The number of unsuccessful pregnancies was higher in the symptomatic untreated women. Conclusions: Fertility in CVID patients is not decreased, and their pregnancies could be considered more risky compared with those of the general population.
Návaznosti
EE2.3.30.0009, projekt VaVNázev: Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci
VytisknoutZobrazeno: 27. 2. 2021 20:05