Expression of apoptosis-related genes in the mouse skin during
the first postnatal catagen stage, focused on localization of
Bnip3L and caspase-12

J 2015

Expression of apoptosis-related genes in the mouse skin during the first postnatal catagen stage, focused on localization of Bnip3L and caspase-12

VESELÁ, Barbora a Eva MATALOVÁ

Základní údaje

Originální název

Expression of apoptosis-related genes in the mouse skin during the first postnatal catagen stage, focused on localization of Bnip3L and caspase-12

Autoři

VESELÁ, Barbora a Eva MATALOVÁ

Vydání

Connective Tissue Research, PHILADELPHIA, TAYLOR & FRANCIS INC, 2015, 0300-8207

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.411

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/15:00108643

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Apoptosis; Bnip3L; caspase-12; hair follicles; PCR arrays

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 4. 2020 16:37, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Hair follicles undergo repetitive stages of cell proliferation and programmed cell death. The catagen stage of physiological apoptosis is connected with dynamic changes in morphology and alterations in gene expression. However, hair follicle apoptosis must be in balance with events in surrounding tissues, such as keratinocyte cornification, to maintain complex skin homeostasis. Several pro- and anti-apoptotic molecules in the skin have been reported but mainly in pathological states. In this investigation, apoptosis-related gene expression was examined during the first catagen stage of mouse hair follicle development by PCR arrays under physiological conditions. Postnatal stages P15 and P17, representing early and late catagen stages, were evaluated relatively to stage P6, representing the hair follicle growing phase, to demonstrate dynamics of gene activation during the catagen. Several statistically significant alterations were observed at P15 and particularly at P17. Bnip3L and caspase-12 identified by the PCR arrays at both catagen stages were additionally localized using immunofluorescence and were reported in physiological hair development for the first time.

Citovat

VESELÁ, Barbora a Eva MATALOVÁ. Expression of apoptosis-related genes in the mouse skin during the first postnatal catagen stage, focused on localization of Bnip3L and caspase-12. Connective Tissue Research. PHILADELPHIA: TAYLOR & FRANCIS INC, 2015, roč. 56, č. 4, s. 326-335. ISSN 0300-8207. Dostupné z: https://doi.org/10.3109/03008207.2015.1040546.

@article{1313264,
   author = {Veselá, Barbora and Matalová, Eva},
   article_location = {PHILADELPHIA},
   article_number = {4},
   doi = {https://doi.org/10.3109/03008207.2015.1040546},
   keywords = {Apoptosis; Bnip3L; caspase-12; hair follicles; PCR arrays},
   language = {eng},
   issn = {0300-8207},
   journal = {Connective Tissue Research},
   title = {Expression of apoptosis-related genes in the mouse skin during the first postnatal catagen stage, focused on localization of Bnip3L and caspase-12},
   url = {http://www.tandfonline.com/doi/abs/10.3109/03008207.2015.1040546?journalCode=icts20},
   volume = {56},
   year = {2015}
}

TY  - JOUR
ID  - 1313264
AU  - Veselá, Barbora - Matalová, Eva
PY  - 2015
TI  - Expression of apoptosis-related genes in the mouse skin during the first postnatal catagen stage, focused on localization of Bnip3L and caspase-12
JF  - Connective Tissue Research
VL  - 56
IS  - 4
SP  - 326-335
EP  - 326-335
PB  - TAYLOR & FRANCIS INC
SN  - 03008207
KW  - Apoptosis
KW  - Bnip3L
KW  - caspase-12
KW  - hair follicles
KW  - PCR arrays
UR  - http://www.tandfonline.com/doi/abs/10.3109/03008207.2015.1040546?journalCode=icts20
L2  - http://www.tandfonline.com/doi/abs/10.3109/03008207.2015.1040546?journalCode=icts20
N2  - Hair follicles undergo repetitive stages of cell proliferation and programmed cell death. The catagen stage of physiological apoptosis is connected with dynamic changes in morphology and alterations in gene expression. However, hair follicle apoptosis must be in balance with events in surrounding tissues, such as keratinocyte cornification, to maintain complex skin homeostasis. Several pro- and anti-apoptotic molecules in the skin have been reported but mainly in pathological states. In this investigation, apoptosis-related gene expression was examined during the first catagen stage of mouse hair follicle development by PCR arrays under physiological conditions. Postnatal stages P15 and P17, representing early and late catagen stages, were evaluated relatively to stage P6, representing the hair follicle growing phase, to demonstrate dynamics of gene activation during the catagen. Several statistically significant alterations were observed at P15 and particularly at P17. Bnip3L and caspase-12 identified by the PCR arrays at both catagen stages were additionally localized using immunofluorescence and were reported in physiological hair development for the first time.
ER  -

VESELÁ, Barbora a Eva MATALOVÁ. Expression of apoptosis-related genes in the mouse skin during the first postnatal catagen stage, focused on localization of Bnip3L and caspase-12. \textit{Connective Tissue Research}. PHILADELPHIA: TAYLOR \&{} FRANCIS INC, 2015, roč.~56, č.~4, s.~326-335. ISSN~0300-8207. Dostupné z: https://doi.org/10.3109/03008207.2015.1040546.

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