2015
Award for the best presentations in the category of BSc/MSc students
ŠKORPÍKOVÁ, LucieZákladní údaje
Originální název
Award for the best presentations in the category of BSc/MSc students
Název česky
Cena za nejlepší prezentace v kategorii Bc./Mgr. studentů
Autoři
Vydání
2015
Nakladatel
Laboratory of Helminthology, Department of Parasitology, Faculty of Science, Charles University in Prague and Czech Society for Parasitology
Další údaje
Jazyk
angličtina
Typ výsledku
Ocenění vědecké a umělecké činnosti
Obor
10600 1.6 Biological sciences
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Označené pro přenos do RIV
Ne
Organizační jednotka
Přírodovědecká fakulta
Klíčová slova anglicky
Trichinella sp.; cystatin; excretory-secretory products
Změněno: 13. 10. 2015 11:27, Mgr. Lucie Škorpíková, Ph.D.
Anotace
V originále
Nematodes of the genus Trichinella are intracellular parasites which invade the cells of small intestine and skeletal muscles. Their global distribution is corresponding to the wide range of their hosts involving mammals, birds and reptiles. Six (T1, T2, T3, T4, T5 and T7) of twelve genotypes (T1-T12) of Trichinella are causative agents of human trichinellosis, a serious disease which has been documented in 55 countries. Our work is focused on cystatins - inhibitors of C1 cysteine peptidases. Their ancestor gene have undergone a complex and dynamic evolution implicating the current high variability of the cystatin group. Despite this fact, three amino acid conserved motifs of cystatin active site remain preserved. Cystatins are involved in many essential biological processes of helminths, including Trichinella spp., like development, growth, migration, digestion, reproduction and also in manipulation of the host immunne system. The presence of some cystatins was confirmed in excretory-secretory products of Trichinella muscle larvae and “multi cystatin-like domain” protein was recognized as a one of the most dominant components.
Návaznosti
| MUNI/A/1484/2014, interní kód MU |
|