| ČULEN, Martin, D. DVOŘÁKOVÁ, Lukáš SEMERÁD, Zuzana ŠUSTKOVÁ, Jana BOUCHNEROVÁ, Martina PALACKOVÁ, Jiří MAYER a Zdeněk RÁČIL. Incorporation of humanized niche as a strategy for improving leukemic engraftment in immunodeficient mice. Transfuze a hematologie dnes. Praha: Česká lékařská společnost J.E.Purkyně, 2015, roč. 21, č. 1, s. 36-41. ISSN 1213-5763. |
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@article{1313807,
author = {Čulen, Martin and Dvořáková, D. and Semerád, Lukáš and Šustková, Zuzana and Bouchnerová, Jana and Palacková, Martina and Mayer, Jiří and Ráčil, Zdeněk},
article_location = {Praha},
article_number = {1},
keywords = {bone marrow; microenvironment; scaffold; biomaterial; leukemia; mesenchymal stromal cell},
language = {eng},
issn = {1213-5763},
journal = {Transfuze a hematologie dnes},
title = {Incorporation of humanized niche as a strategy for improving leukemic engraftment in immunodeficient mice},
volume = {21},
year = {2015}
}
TY - JOUR
ID - 1313807
AU - Čulen, Martin - Dvořáková, D. - Semerád, Lukáš - Šustková, Zuzana - Bouchnerová, Jana - Palacková, Martina - Mayer, Jiří - Ráčil, Zdeněk
PY - 2015
TI - Incorporation of humanized niche as a strategy for improving leukemic engraftment in immunodeficient mice
JF - Transfuze a hematologie dnes
VL - 21
IS - 1
SP - 36-41
EP - 36-41
PB - Česká lékařská společnost J.E.Purkyně
SN - 12135763
KW - bone marrow
KW - microenvironment
KW - scaffold
KW - biomaterial
KW - leukemia
KW - mesenchymal stromal cell
N2 - In vivo models of patient derived leukemias are utilized using immunodeficient mice that provide engraftment of xeno--transplanted leukemic cells without their rejection. Despite the achievement of considerable immunosuppression in the latest immunecompromised mouse, engraftment of patient samples is still not always possible or does not fully reflect the original disease characteristics. This points to the presence of inter-species differences in the hematopoietic niche. In order to improve engraftment options, a valid proposition is to model the human niche in mice. In recent years, this has been performed by adopting an osteogenic approach already used in bone-regenerative medicine and based on using a suitable biomaterial along with mesenchymal stromal cells capable of bone-formation. The review aims to present and discuss works describing leukemic engraftment in a hybrid-mouse model containing a humanized microenvironment and to point out important details and possible future directions of this research.
ER -
ČULEN, Martin, D. DVOŘÁKOVÁ, Lukáš SEMERÁD, Zuzana ŠUSTKOVÁ, Jana BOUCHNEROVÁ, Martina PALACKOVÁ, Jiří MAYER a Zdeněk RÁČIL. Incorporation of humanized niche as a strategy for improving leukemic engraftment in immunodeficient mice. \textit{Transfuze a hematologie dnes}. Praha: Česká lékařská společnost J.E.Purkyně, 2015, roč.~21, č.~1, s.~36-41. ISSN~1213-5763.
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