Investigating the amoebicidal activity of Indonesian plant
extracts possibly used as medicinal plants by orangutans

k 2015

Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans

STUART, Peter Daniel; Ibne ALI; Karel DOLEŽAL; Erhan YALCINDAG; Radka PECKOVÁ et al.

Základní údaje

Originální název

Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans

Autoři

STUART, Peter Daniel; Ibne ALI; Karel DOLEŽAL; Erhan YALCINDAG; Radka PECKOVÁ; Milan OLŠANSKÝ; Wisnu NURCAHYO a Ivona FOITOVÁ

Vydání

Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) San Diego 2015, 2015

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

40301 Veterinary science

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

website

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/15:00081110

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Entamoeba; Orangutan; Parasite; Disease; Plant extract

Změněno: 1. 4. 2016 10:19, Mgr. Lucie Jarošová, DiS.

Anotace

V originále

Presenter’s Email: peterdstuart@hotmail.com Amoebiasis, the condition that results from infection with Entamoeba histolytica, is a major global health concern. Infection is common in the tropics, including South-East Asia. Infection can also occur in non-human primates and most recently has been observed in wild orangutans (Pongo sp.). Plants from Indonesia were selected to be tested for activity against E. histolytica, based on observations that orangutans were consuming them more when infected with parasitic protozoa. Methanol and Methanol:Tetrahydrofuran crude extracts were obtained from four plants: Achidendron fagifollium, Diospyros sumatra, Piper betle and Shorea sumatrana. Of these D. sumatra and P. betle showed activity against E. histolytica (IC50 <47microg/ml and IC50 <67 mikrog/ml respectively). The results support the use of these plants for dysentery by local people. They also demonstrate for the first time, that orangutans may be directly self-medicating. Preliminary trials of these plants on N. fowleri suggest further trials are warranted.

Návaznosti

GAP505/11/1163, projekt VaV

Název: Protizánětlivá aktivita extraktů z rostlin Indonésie a jejich účinek na průběh oportunních parazitóz

Investor: Grantová agentura ČR, Protizánětlivá aktivita extraktů z rostlin Indonésie a jejich účinek na průběh oportunních parazitóz

Citovat

STUART, Peter Daniel; Ibne ALI; Karel DOLEŽAL; Erhan YALCINDAG; Radka PECKOVÁ; Milan OLŠANSKÝ; Wisnu NURCAHYO a Ivona FOITOVÁ. Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans. In Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) San Diego 2015. 2015.

@proceedings{1313841,
   author = {Stuart, Peter Daniel and Ali, Ibne and Doležal, Karel and Yalcindag, Erhan and Pecková, Radka and Olšanský, Milan and Nurcahyo, Wisnu and Foitová, Ivona},
   booktitle = {Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) San Diego 2015},
   keywords = {Entamoeba; Orangutan; Parasite; Disease; Plant extract},
   language = {eng},
   title = {Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans},
   url = {http://www.icaac.org/},
   year = {2015}
}

TY  - CONF
ID  - 1313841
AU  - Stuart, Peter Daniel - Ali, Ibne - Doležal, Karel - Yalcindag, Erhan - Pecková, Radka - Olšanský, Milan - Nurcahyo, Wisnu - Foitová, Ivona
PY  - 2015
TI  - Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans
KW  - Entamoeba
KW  - Orangutan
KW  - Parasite
KW  - Disease
KW  - Plant extract
UR  - http://www.icaac.org/
L2  - http://www.icaac.org/
N2  - Presenter’s Email: peterdstuart@hotmail.com Amoebiasis, the condition that results from infection with Entamoeba histolytica, is a major global health concern. Infection is common in the tropics, including South-East Asia. Infection can also occur in non-human primates and most recently has been observed in wild orangutans (Pongo sp.). Plants from Indonesia were selected to be tested for activity against E. histolytica, based on observations that orangutans were consuming them more when infected with parasitic protozoa. Methanol and Methanol:Tetrahydrofuran crude extracts were obtained from four plants: Achidendron fagifollium, Diospyros sumatra, Piper betle and Shorea sumatrana. Of these D. sumatra and P. betle showed activity against E. histolytica (IC50 <47microg/ml and IC50 <67 mikrog/ml respectively). The results support the use of these plants for dysentery by local people. They also demonstrate for the first time, that orangutans may be directly self-medicating. Preliminary trials of these plants on N. fowleri suggest further trials are warranted.
ER  -

STUART, Peter Daniel; Ibne ALI; Karel DOLEŽAL; Erhan YALCINDAG; Radka PECKOVÁ; Milan OLŠANSKÝ; Wisnu NURCAHYO a Ivona FOITOVÁ. Investigating the amoebicidal activity of Indonesian plant extracts possibly used as medicinal plants by orangutans. In \textit{Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) San Diego 2015}. 2015.

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