| BABULA, Petr, Bořivoj KLEJDUS, Jozef KOVACIK, Josef HEDBAVNY a Marián HLAVNA. Lanthanum rather than cadmium induces oxidative stress and metabolite changes in Hypericum perforatum. Journal of Hazardous Materials. Amsterdam: Elsevier Science BV., 2015, roč. 286, April 9, s. 334-342. ISSN 0304-3894. Dostupné z: https://dx.doi.org/10.1016/j.jhazmat.2014.12.060. |
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@article{1314381,
author = {Babula, Petr and Klejdus, Bořivoj and Kovacik, Jozef and Hedbavny, Josef and Hlavna, Marián},
article_location = {Amsterdam},
article_number = {April 9},
doi = {http://dx.doi.org/10.1016/j.jhazmat.2014.12.060},
keywords = {Antioxidants; Fluorescence microscopy; HPLC-MS/MS; Oxidative stress; Rare earth elements},
language = {eng},
issn = {0304-3894},
journal = {Journal of Hazardous Materials},
title = {Lanthanum rather than cadmium induces oxidative stress and metabolite changes in Hypericum perforatum},
volume = {286},
year = {2015}
}
TY - JOUR
ID - 1314381
AU - Babula, Petr - Klejdus, Bořivoj - Kovacik, Jozef - Hedbavny, Josef - Hlavna, Marián
PY - 2015
TI - Lanthanum rather than cadmium induces oxidative stress and metabolite changes in Hypericum perforatum
JF - Journal of Hazardous Materials
VL - 286
IS - April 9
SP - 334-342
EP - 334-342
PB - Elsevier Science BV.
SN - 03043894
KW - Antioxidants
KW - Fluorescence microscopy
KW - HPLC-MS/MS
KW - Oxidative stress
KW - Rare earth elements
N2 - Physiology, oxidative stress and production of metabolites in Hypericum perforatum exposed to moderate Cd and/or La concentration (10 mu M) were studied. La evoked increase in reactive oxygen species, malondialdehyde and proline but suppressed growth, tissue water content, glutathione, ascorbic acid and affected mineral nutrient contents more than Cd while the impact of Cd + La was not synergistic. Similar trend was observed at the level of superoxide dismutase gene expression. Shoot Cd amount increased in Cd + La while only root La increased in the same treatment. Extensive quantification of secondary metabolites revealed that La affected phenolic acids more pronouncedly than Cd in shoots and roots. Flavonols were suppressed by La that could contribute to the appearance of oxidative damage. Procyanidins increased in response to La in the shoots but decreased in the roots. Metabolic responses in Cd + La treatment resembled those of La treatment (almost identically in the roots). Phenylalanine ammonia-lyase activity was mainly suppressed by La. The presence of La also depleted amount of hypericin and expression of its putative gene (hyp-1) showed similar trend but accumulation of hyperforin increased under Cd or La excess. Clear differences in the stem and root anatomy in response to Cd or La were also found. Overall, H. perforatum is La-sensitive species and rather Cd ameliorated negative impact of La.
ER -
BABULA, Petr, Bořivoj KLEJDUS, Jozef KOVACIK, Josef HEDBAVNY a Marián HLAVNA. Lanthanum rather than cadmium induces oxidative stress and metabolite changes in Hypericum perforatum. \textit{Journal of Hazardous Materials}. Amsterdam: Elsevier Science BV., 2015, roč.~286, April 9, s.~334-342. ISSN~0304-3894. Dostupné z: https://dx.doi.org/10.1016/j.jhazmat.2014.12.060.
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