| HOFFMANN, V.S., M. BACCARANI, J. HASFORD, D. LINDOERFER, S. BURGSTALLER, D. SERTIC, P. COSTEAS, Jiří MAYER, K. INDRAK, H. EVERAUS, P. KOSKENVESA, J. GUILHOT, G. SCHUBERT-FRITSCHLE, F. CASTAGNETTI, F. DI RAIMONDO, S. LEJNIECE, L. GRISKEVICIUS, N. THIELEN, T. SACHA, A. HELLMANN, A.G. TURKINA, A. ZARITSKEY, A. BOGDANOVICH, Z. SNINSKÁ, I. ZUPAN, J.L. STEEGMANN, B. SIMONSSON, R.E. CLARK, A. COVELLI, G. GUIDI a R. HEHLMANN. The EUTOS population-based registry: incidence and clinical characteristics of 2904 CML patients in 20 European Countries. Leukemia. London: Nature Publishing Group, 2015, roč. 29, č. 6, s. 1336-1343. ISSN 0887-6924. Dostupné z: https://dx.doi.org/10.1038/leu.2015.73. |
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@article{1315211,
author = {Hoffmann, V.S. and Baccarani, M. and Hasford, J. and Lindoerfer, D. and Burgstaller, S. and Sertic, D. and Costeas, P. and Mayer, Jiří and Indrak, K. and Everaus, H. and Koskenvesa, P. and Guilhot, J. and SchubertandFritschle, G. and Castagnetti, F. and Di Raimondo, F. and Lejniece, S. and Griskevicius, L. and Thielen, N. and Sacha, T. and Hellmann, A. and Turkina, A.G. and Zaritskey, A. and Bogdanovich, A. and Sninská, Z. and Zupan, I. and Steegmann, J.L. and Simonsson, B. and Clark, R.E. and Covelli, A. and Guidi, G. and Hehlmann, R.},
article_location = {London},
article_number = {6},
doi = {http://dx.doi.org/10.1038/leu.2015.73},
keywords = {CHRONIC MYELOID-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; HEMATOLOGIC MALIGNANCIES; IMATINIB TREATMENT; INTERFERON-ALPHA; PROGNOSTIC SCORE; WORKING PARTY; FRONTLINE; SURVIVAL; THERAPY},
language = {eng},
issn = {0887-6924},
journal = {Leukemia},
title = {The EUTOS population-based registry: incidence and clinical characteristics of 2904 CML patients in 20 European Countries},
volume = {29},
year = {2015}
}
TY - JOUR
ID - 1315211
AU - Hoffmann, V.S. - Baccarani, M. - Hasford, J. - Lindoerfer, D. - Burgstaller, S. - Sertic, D. - Costeas, P. - Mayer, Jiří - Indrak, K. - Everaus, H. - Koskenvesa, P. - Guilhot, J. - Schubert-Fritschle, G. - Castagnetti, F. - Di Raimondo, F. - Lejniece, S. - Griskevicius, L. - Thielen, N. - Sacha, T. - Hellmann, A. - Turkina, A.G. - Zaritskey, A. - Bogdanovich, A. - Sninská, Z. - Zupan, I. - Steegmann, J.L. - Simonsson, B. - Clark, R.E. - Covelli, A. - Guidi, G. - Hehlmann, R.
PY - 2015
TI - The EUTOS population-based registry: incidence and clinical characteristics of 2904 CML patients in 20 European Countries
JF - Leukemia
VL - 29
IS - 6
SP - 1336-1343
EP - 1336-1343
PB - Nature Publishing Group
SN - 08876924
KW - CHRONIC MYELOID-LEUKEMIA
KW - CHRONIC MYELOGENOUS LEUKEMIA
KW - HEMATOLOGIC MALIGNANCIES
KW - IMATINIB TREATMENT
KW - INTERFERON-ALPHA
KW - PROGNOSTIC SCORE
KW - WORKING PARTY
KW - FRONTLINE
KW - SURVIVAL
KW - THERAPY
N2 - This population-based registry was designed to provide robust and updated information on the characteristics and the epidemiology of chronic myeloid leukemia (CML). All cases of newly diagnosed Philadelphia positive, BCR-ABL1+ CML that occurred in a sample of 92.5 million adults living in 20 European countries, were registered over a median period of 39 months. 94.3% of the 2904 CML patients were diagnosed in chronic phase (CP). Median age was 56 years. 55.5% of patients had comorbidities, mainly cardiovascular (41.9%). High-risk patients were 24.7% by Sokal, 10.8% by EURO, and 11.8% by EUTOS risk scores. The raw incidence increased with age from 0.39/100 000/year in people 20-29 years old to 1.52 in those >70 years old, and showed a maximum of 1.39 in Italy and a minimum of 0.69 in Poland (all countries together: 0.99). The proportion of Sokal and Euro score high-risk patients seen in many countries indicates that trial patients were not a positive selection. Thus from a clinical point of view the results of most trials can be generalized to most countries. The incidences observed among European countries did not differ substantially. The estimated number of new CML cases per year in Europe is about 6370.
ER -
HOFFMANN, V.S., M. BACCARANI, J. HASFORD, D. LINDOERFER, S. BURGSTALLER, D. SERTIC, P. COSTEAS, Jiří MAYER, K. INDRAK, H. EVERAUS, P. KOSKENVESA, J. GUILHOT, G. SCHUBERT-FRITSCHLE, F. CASTAGNETTI, F. DI RAIMONDO, S. LEJNIECE, L. GRISKEVICIUS, N. THIELEN, T. SACHA, A. HELLMANN, A.G. TURKINA, A. ZARITSKEY, A. BOGDANOVICH, Z. SNINSKÁ, I. ZUPAN, J.L. STEEGMANN, B. SIMONSSON, R.E. CLARK, A. COVELLI, G. GUIDI a R. HEHLMANN. The EUTOS population-based registry: incidence and clinical characteristics of 2904 CML patients in 20 European Countries. \textit{Leukemia}. London: Nature Publishing Group, 2015, roč.~29, č.~6, s.~1336-1343. ISSN~0887-6924. Dostupné z: https://dx.doi.org/10.1038/leu.2015.73.
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