2016
The contribution of white matter lesions to Parkinson's disease motor and gait symptoms: a critical review of the literature
VESELÝ, Branislav, Antonini ANGELO a Ivan REKTORZákladní údaje
Originální název
The contribution of white matter lesions to Parkinson's disease motor and gait symptoms: a critical review of the literature
Autoři
VESELÝ, Branislav (703 Slovensko), Antonini ANGELO (380 Itálie) a Ivan REKTOR (203 Česká republika, garant, domácí)
Vydání
Journal of Neural Transmission, Wien, SPRINGER WIEN, 2016, 0300-9564
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30000 3. Medical and Health Sciences
Stát vydavatele
Rakousko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 2.392
Kód RIV
RIV/00216224:14740/16:00089148
Organizační jednotka
Středoevropský technologický institut
UT WoS
000373162900010
Klíčová slova anglicky
White matter lesions; Cerebrovascular disease; Parkinson's disease; Magnetic resonance imaging
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 9. 1. 2017 09:44, Mgr. Eva Špillingová
Anotace
V originále
White matter lesions (WML) associated with cerebrovascular disease (CVD) may be observed on magnetic resonance imaging in Parkinson's disease (PD) patients. WML are an important factor contributing to postural, gait, and cognitive impairment in the elderly without PD and worsening the course of Alzheimer's disease (AD). Numerous articles are available on this topic. Whether WML modify and negatively influence the clinical symptoms, and course of PD is a subject of debate. The aim of this review is to examine the available literature on the contribution of WML to PD motor symptoms in relation to clinical characteristics and methods of assessing WML on MRI. After reviewing the database, we identified 19 studies reporting the relationship between WML and PD; ten studies focusing on the impact of WML on the cognitive status in PD were excluded. We analysed altogether nine studies reporting the relationship between WML and motor signs of PD. The review found association between WML severity and freezing of gait, less significant to responsiveness to dopaminergic treatment and postural instability; no negative impact on tremor and falls was observed. The impact of WML on bradykinesia and rigidity was inconsistent. Comorbid WML is associated with worsening axial motor performance, probably independently from the degree of nigrostriatal dopaminergic denervation in PD. Reducing the vascular risk factors that cause WML may be helpful in preventing the development of axial symptoms and ultimately in improving the quality of life of patients with PD. Given the lack of systematic studies, additional research in this field is needed.