| GOLUNOVA, A., Josef JAROŠ, Veronika JURTÍKOVÁ, I. KOTELNIKOV, J. KOTEK, H. HLÍDKOVÁ, Libor STREIT, Aleš HAMPL, F. RYPÁČEK a V. PROKS. N-(2-Hydroxypropyl) Methacrylamide Based Cryogels – Synthesis and Biomimetic Modification for Stem Cell Applications. Physiological Research. Praha: Fyziologický ústav AV ČR, 2015, roč. 64, Suppl. 1, s. "S19"-"S27", 9 s. ISSN 0862-8408. |
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@article{1317742,
author = {Golunova, A. and Jaroš, Josef and Jurtíková, Veronika and Kotelnikov, I. and Kotek, J. and Hlídková, H. and Streit, Libor and Hampl, Aleš and Rypáček, F. and Proks, V.},
article_location = {Praha},
article_number = {Suppl. 1},
keywords = {Hydrogels; Cryogels; Stem cells; Scaffolds; Mechanical properties},
language = {eng},
issn = {0862-8408},
journal = {Physiological Research},
title = {N-(2-Hydroxypropyl) Methacrylamide Based Cryogels – Synthesis and Biomimetic Modification for Stem Cell Applications},
volume = {64},
year = {2015}
}
TY - JOUR
ID - 1317742
AU - Golunova, A. - Jaroš, Josef - Jurtíková, Veronika - Kotelnikov, I. - Kotek, J. - Hlídková, H. - Streit, Libor - Hampl, Aleš - Rypáček, F. - Proks, V.
PY - 2015
TI - N-(2-Hydroxypropyl) Methacrylamide Based Cryogels – Synthesis and Biomimetic Modification for Stem Cell Applications
JF - Physiological Research
VL - 64
IS - Suppl. 1
SP - "S19"-"S27"
EP - "S19"-"S27"
PB - Fyziologický ústav AV ČR
SN - 08628408
KW - Hydrogels
KW - Cryogels
KW - Stem cells
KW - Scaffolds
KW - Mechanical properties
N2 - The design of favorable mechanical properties and suitable surface modifications of hydrogels in order to stimulate specific cell response is a great challenge. N-(2-Hydroxypropyl) methacryl-amide (HPMA) was utilized to form macroporous cryogel scaffolds for stem cell applications. Furthermore, one group of scaffolds was enhanced by copolymerization of HPMA with methacryloyl-GGGRGDS-OH peptide in an effort to integrate biomimetic adhesion sites. The cryogels were characterized by stiffness and equilibrium swelling measurements as well as by scanning electron microscopy. Cell culture experiments were performed with human adipose-derived stem cells and substrates were found completely non-toxic. Moreover, RGDS-enriched cryogels supported cell attachment, spreading and proliferation, so they can be considered suitable for designed aims.
ER -
GOLUNOVA, A., Josef JAROŠ, Veronika JURTÍKOVÁ, I. KOTELNIKOV, J. KOTEK, H. HLÍDKOVÁ, Libor STREIT, Aleš HAMPL, F. RYPÁČEK a V. PROKS. N-(2-Hydroxypropyl) Methacrylamide Based Cryogels – Synthesis and Biomimetic Modification for Stem Cell Applications. \textit{Physiological Research}. Praha: Fyziologický ústav AV ČR, 2015, roč.~64, Suppl. 1, s.~''S19''-''S27'', 9 s. ISSN~0862-8408.
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