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@proceedings{1317992,
author = {Langová, Petra and Moravcová Balková, Simona and Buchtová, marcela},
booktitle = {Morphology 2015},
keywords = {odontogenesis; gene expression},
language = {eng},
title = {Microarray analysis of mandible regionalization during mouse development},
year = {2015}
}
TY - CONF
ID - 1317992
AU - Langová, Petra - Moravcová Balková, Simona - Buchtová, marcela
PY - 2015
TI - Microarray analysis of mandible regionalization during mouse development
KW - odontogenesis
KW - gene expression
N2 - The mammalian teeth function to capture and chew food and they have become specialized for these purposes producing a complex and distinctive dentition consisting of unicuspid and multicuspid teeth. To achieve this specialization, tooth development is characterized by a complex series of reciprocal interactions that occur between the epithelium and the underlying cranial neural crest-derived mesenchyme that regulates tooth morphogenesis and differentiation at molecular level. Up to now several homeobox genes are known to be expressed in specific pattern of mouse mandible that specifies the incisor and molar area. However, there are still many unsolved questions how complex signaling between the epithelium and mesenchyme is regulated during initial development of different classes of teeth. To reveal these complex molecular bases of tooth development, a polygenetic approach is needed. Here, we aim to uncover signaling cascades between the oral epithelium and mesenchyme along the jaw that underlay heterodont dentition in mammals.
ER -
LANGOVÁ, Petra, Simona MORAVCOVÁ BALKOVÁ a marcela BUCHTOVÁ. Microarray analysis of mandible regionalization during mouse development. In \textit{Morphology 2015}. 2015. ISSN~1213-8118.
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