Prognostic markers of sarcoidosis: an analysis of patients from
everyday pneumological practice

J 2015

Prognostic markers of sarcoidosis: an analysis of patients from everyday pneumological practice

DOUBKOVÁ, Martina, Zdeněk POSPÍŠIL, Jana SKŘIČKOVÁ a Michael DOUBEK

Základní údaje

Originální název

Prognostic markers of sarcoidosis: an analysis of patients from everyday pneumological practice

Autoři

DOUBKOVÁ, Martina (203 Česká republika, domácí), Zdeněk POSPÍŠIL (203 Česká republika, domácí), Jana SKŘIČKOVÁ (203 Česká republika, garant, domácí) a Michael DOUBEK (203 Česká republika, domácí)

Vydání

Clinical Respiratory Journal, Hoboken, Wiley-Blackwell, 2015, 1752-6981

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30203 Respiratory systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.147

Kód RIV

RIV/00216224:14110/15:00084854

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/crj.12160

UT WoS

000362588000010

EID Scopus

2-s2.0-84943357857

Klíčová slova anglicky

diagnosis; prognostic factors; sarcoidosis; therapy

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 11. 2015 15:24, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

IntroductionAlthough sarcoidosis is a well-known disease, sarcoidosis patient outcome and the role of prognostic markers in everyday practice have not yet been well described. Therefore, the goal of the present study was to analyse the fate of sarcoidosis patients and the factors influencing the disease's behaviour in routine practice. MethodsThe study was a retrospective analysis of 306 consecutive patients (181 females and 125 males; median age 45 years) diagnosed with sarcoidosis in the years 2003-2012. ResultsThrough the use of uniparametric analysis, it was determined that the stage of the disease, organ involvement, CD4/CD8 ratio in the bronchoalveolar lavage fluid (BALF), serum and urine calcium levels, smoking, and pulmonary functions had a significant influence on spontaneous sarcoidosis resolution. Multiparametric analysis revealed that spontaneous resolution was significantly positively influenced by female gender, a less advanced disease stage, a higher CD4/CD8 ratio in the BALF, lymphocytosis in the BALF and normal pulmonary functions at diagnosis. During follow-up, only three patients died. The causes of death were respiratory failure with pneumonia (n=2) and heart attack caused by sarcoidosis heart involvement (n=1). ConclusionThe data show sarcoidosis as a disorder with high variability in clinical and laboratory findings but with good general prognosis.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

DOUBKOVÁ, Martina, Zdeněk POSPÍŠIL, Jana SKŘIČKOVÁ a Michael DOUBEK. Prognostic markers of sarcoidosis: an analysis of patients from everyday pneumological practice. Clinical Respiratory Journal. Hoboken: Wiley-Blackwell, 2015, roč. 9, č. 4, s. 443-449. ISSN 1752-6981. Dostupné z: https://dx.doi.org/10.1111/crj.12160.

@article{1318533,
   author = {Doubková, Martina and Pospíšil, Zdeněk and Skřičková, Jana and Doubek, Michael},
   article_location = {Hoboken},
   article_number = {4},
   doi = {http://dx.doi.org/10.1111/crj.12160},
   keywords = {diagnosis; prognostic factors; sarcoidosis; therapy},
   language = {eng},
   issn = {1752-6981},
   journal = {Clinical Respiratory Journal},
   title = {Prognostic markers of sarcoidosis: an analysis of patients from everyday pneumological practice},
   volume = {9},
   year = {2015}
}

TY  - JOUR
ID  - 1318533
AU  - Doubková, Martina - Pospíšil, Zdeněk - Skřičková, Jana - Doubek, Michael
PY  - 2015
TI  - Prognostic markers of sarcoidosis: an analysis of patients from everyday pneumological practice
JF  - Clinical Respiratory Journal
VL  - 9
IS  - 4
SP  - 443-449
EP  - 443-449
PB  - Wiley-Blackwell
SN  - 17526981
KW  - diagnosis
KW  - prognostic factors
KW  - sarcoidosis
KW  - therapy
N2  - IntroductionAlthough sarcoidosis is a well-known disease, sarcoidosis patient outcome and the role of prognostic markers in everyday practice have not yet been well described. Therefore, the goal of the present study was to analyse the fate of sarcoidosis patients and the factors influencing the disease's behaviour in routine practice. MethodsThe study was a retrospective analysis of 306 consecutive patients (181 females and 125 males; median age 45 years) diagnosed with sarcoidosis in the years 2003-2012. ResultsThrough the use of uniparametric analysis, it was determined that the stage of the disease, organ involvement, CD4/CD8 ratio in the bronchoalveolar lavage fluid (BALF), serum and urine calcium levels, smoking, and pulmonary functions had a significant influence on spontaneous sarcoidosis resolution. Multiparametric analysis revealed that spontaneous resolution was significantly positively influenced by female gender, a less advanced disease stage, a higher CD4/CD8 ratio in the BALF, lymphocytosis in the BALF and normal pulmonary functions at diagnosis. During follow-up, only three patients died. The causes of death were respiratory failure with pneumonia (n=2) and heart attack caused by sarcoidosis heart involvement (n=1). ConclusionThe data show sarcoidosis as a disorder with high variability in clinical and laboratory findings but with good general prognosis.
ER  -

DOUBKOVÁ, Martina, Zdeněk POSPÍŠIL, Jana SKŘIČKOVÁ a Michael DOUBEK. Prognostic markers of sarcoidosis: an analysis of patients from everyday pneumological practice. \textit{Clinical Respiratory Journal}. Hoboken: Wiley-Blackwell, 2015, roč.~9, č.~4, s.~443-449. ISSN~1752-6981. Dostupné z: https://dx.doi.org/10.1111/crj.12160.

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