Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors

C 2015

Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors

VYCHYTILOVÁ, Petra a Ondřej SLABÝ

Základní údaje

Originální název

Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors

Autoři

VYCHYTILOVÁ, Petra (203 Česká republika, domácí) a Ondřej SLABÝ (203 Česká republika, garant, domácí)

Vydání

Basel, Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance, od s. 75-122, 48 s. Experientia Supplementum, Volume 106, 2015

Nakladatel

Springer

Další údaje

Jazyk

angličtina

Typ výsledku

Kapitola resp. kapitoly v odborné knize

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

tištěná verze "print"

Kód RIV

RIV/00216224:14740/15:00084969

Organizační jednotka

Středoevropský technologický institut

ISBN

978-3-0348-0953-5

Klíčová slova anglicky

Circulating microRNAs; Diagnostic biomarkers; Predictive biomarkers; Prognostic biomarkers; Solid tumors

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 11. 2015 15:27, Mgr. Petra Vychytilová, Ph.D.

Anotace

V originále

One of the major challenges in cancer research is the identification of stable biomarkers that could be routinely measured in easily accessible samples. Human blood and other body fluids represent rich sources for the identification of novel biomarkers. It is apparent that the availability of these biomarkers would improve an early detection of asymptomatic disease and the clinical management of cancer. MicroRNAs have been described to be present in various types of body fluids including cell-free serum and plasma. These days, the involvement of microRNAs in molecular pathology of cancer is well established. Moreover, it seems that these molecules could be optimal noninvasive biomarkers owing to their high stability under storage and handling conditions and high sensitivity and specificity in various diseases. To date, more than 100 circulating microRNAs with the potential to serve as novel diagnostic, prognostic, or predictive biomarkers for different types of cancers have been identified, and this number is still increasing. However, there are major discrepancies in the findings by different research groups, and few commonly altered microRNAs have been reported in these studies. Further studies on large cohorts using uniform methodology are warranted to establish the clinical applicability of circulating microRNAs for solid tumors. Here, we summarize the tumor-specific profiles of blood-borne microRNAs and discuss their potential utility for personalized medicine of solid tumors.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

NT13547, projekt VaV

Název: Studium mikroRNA a genů asociovaných s procesem epiteliálně-mezenchymální tranzice jako potenciálních markerů pro predikci rizika a časný záchyt metastazování u pacientů s renálním karcinomem

NT13549, projekt VaV

Název: Vytvoření diagnostické sady cirkulujících mikroRNA pro neinvazivní časnou diagnostiku a sledování pacientů s kolorektálním karcinomem

NV15-34678A, projekt VaV

Název: Molekulární prognostické a prediktivní faktory u pacientů s metastatickým renálním karcinomem léčených tyrozinkinázovými inhibitory

Citovat

VYCHYTILOVÁ, Petra a Ondřej SLABÝ. Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors. In Peter Igaz. Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance. Basel: Springer, 2015, s. 75-122. Experientia Supplementum, Volume 106. ISBN 978-3-0348-0953-5.

@inbook{1318911,
   author = {Vychytilová, Petra and Slabý, Ondřej},
   address = {Basel},
   booktitle = {Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance},
   editor = {Peter Igaz},
   keywords = {Circulating microRNAs; Diagnostic biomarkers; Predictive biomarkers; Prognostic biomarkers; Solid tumors},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Basel},
   isbn = {978-3-0348-0953-5},
   pages = {75-122},
   publisher = {Springer},
   title = {Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors},
   year = {2015}
}

TY  - CHAP
ID  - 1318911
AU  - Vychytilová, Petra - Slabý, Ondřej
PY  - 2015
TI  - Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors
VL  - Experientia Supplementum, Volume 106
PB  - Springer
CY  - Basel
SN  - 9783034809535
KW  - Circulating microRNAs
KW  - Diagnostic biomarkers
KW  - Predictive biomarkers
KW  - Prognostic biomarkers
KW  - Solid tumors
N2  - One of the major challenges in cancer research is the identification of stable biomarkers that could be routinely measured in easily accessible samples. Human blood and other body fluids represent rich sources for the identification of novel biomarkers. It is apparent that the availability of these biomarkers would improve an early detection of asymptomatic disease and the clinical management of cancer. MicroRNAs have been described to be present in various types of body fluids including cell-free serum and plasma. These days, the involvement of microRNAs in molecular pathology of cancer is well established. Moreover, it seems that these molecules could be optimal noninvasive biomarkers owing to their high stability under storage and handling conditions and high sensitivity and specificity in various diseases. To date, more than 100 circulating microRNAs with the potential to serve as novel diagnostic, prognostic, or predictive biomarkers for different types of cancers have been identified, and this number is still increasing. However, there are major discrepancies in the findings by different research groups, and few commonly altered microRNAs have been reported in these studies. Further studies on large cohorts using uniform methodology are warranted to establish the clinical applicability of circulating microRNAs for solid tumors. Here, we summarize the tumor-specific profiles of blood-borne microRNAs and discuss their potential utility for personalized medicine of solid tumors.
ER  -

VYCHYTILOVÁ, Petra a Ondřej SLABÝ. Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors. In Peter Igaz. \textit{Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance}. Basel: Springer, 2015, s.~75-122. Experientia Supplementum, Volume 106. ISBN~978-3-0348-0953-5.

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