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@inbook{1319460, author = {Juřica, Jan and Turjap, Miroslav and Nosková, Kristýna}, address = {New York}, booktitle = {Dextromethorphan: Pharmacology, Clinical Uses and Health Effects}, editor = {Xin Wang}, keywords = {dextromethorphan; CYP3A4; CYP2D6; metabolic phenotype}, howpublished = {elektronická verze "online"}, language = {eng}, location = {New York}, isbn = {978-1-63484-024-8}, pages = {137-151}, publisher = {Nova Science Publishers}, title = {Dextromethorphan as a Probe Drug for CYP2D6 and CYP3A4 Phenotyping}, year = {2015} }
TY - CHAP ID - 1319460 AU - Juřica, Jan - Turjap, Miroslav - Nosková, Kristýna PY - 2015 TI - Dextromethorphan as a Probe Drug for CYP2D6 and CYP3A4 Phenotyping VL - Nova Biomedical PB - Nova Science Publishers CY - New York SN - 9781634840248 KW - dextromethorphan KW - CYP3A4 KW - CYP2D6 KW - metabolic phenotype N2 - Chapter summarizes the use of dextromethorphan as a marker substrate for CYP2D6 and CYP3A4 metabolic activity determination. The ratio of the concentration of the specific substrate to the metabolite(s) in various biological matrices (saliva, plasma/serum, urine) is the most widely used methodological approach to assess metabolic activity in vivo. ER -
JUŘICA, Jan, Miroslav TURJAP and Kristýna NOSKOVÁ. Dextromethorphan as a Probe Drug for CYP2D6 and CYP3A4 Phenotyping. Online. In Xin Wang. \textit{Dextromethorphan: Pharmacology, Clinical Uses and Health Effects}. New York: Nova Science Publishers, 2015, p.~137-151. Nova Biomedical. ISBN~978-1-63484-024-8.
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